Assessing Disparities in the Prevalence of Atopic Comorbidities Among Food-Allergic Children

Anandu Dileep; Christopher Warren; Lucy A. Bilaver; Ellen Stephen; Aame B. Andy-Nweye; Susan Fox; Jialing Jiang; Pamela J. Newmark; Annika Chura; Iman Abdikarim; Sai R. Nimmagadda; Hemant P. Sharma; Mary C. Tobin; Amal H. Assa'ad; Ruchi S. Gupta; Mahboobeh Mahdavinia

doi:10.1016/j.jaip.2023.01.020

Assessing Disparities in the Prevalence of Atopic Comorbidities Among Food-Allergic Children

Anandu Dileep, Christopher Warren, Lucy A. Bilaver, Ellen Stephen, Aame B. Andy-Nweye, Susan Fox, Jialing Jiang, Pamela J. Newmark, Annika Chura, Iman Abdikarim, Sai R. Nimmagadda, Hemant P. Sharma, Mary C. Tobin, Amal H. Assa'ad, Ruchi S. Gupta, Mahboobeh Mahdavinia^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background: Previous studies have reported that Black children with food allergy (FA) have higher risk of atopic comorbidities than White children. Objective: Our study sought to understand if disparities in the prevalence of atopic comorbidities among children with FA are driven by individual and community-level socioeconomic status (SES). Methods: We analyzed data from a prospective, multicenter cohort investigating the natural history of pediatric atopy: the Food Allergy Outcomes Related to White and African American Racial Differences (FORWARD) study. A validated, multicomponent area deprivation index (ADI) percentile score was tabulated by the census block group for each subject's home address. The association of ADI with atopic comorbidities in FA was assessed via multivariable regression analysis. Results: Of the 700 children in this study, the mean ADI was 37.7 (95% confidence interval: 35.6-39.7). The mean ADI was higher in children with asthma (43.3) compared with those without asthma (31.8), which remained significant after adjusting for race (P < .0001). Children with allergic rhinitis (AR) had a higher mean ADI (39.1) compared with those without (33.4) (P = .008). ADI was associated with secondhand smoking, parents’ education, and household income. Black children had a higher risk for asthma after adjusting for ADI and SES-related factors. Conclusion: The independent association of ADI with asthma and AR, regardless of race, suggests a role of neighborhood-level socioeconomic deprivation in the development of these conditions among children with FA. Black children with FA remained at higher risk for asthma after adjusting for SES-related variables, which can indicate an independent risk for asthma in these children.

Original language	English (US)
Pages (from-to)	1169-1176
Number of pages	8
Journal	Journal of Allergy and Clinical Immunology: In Practice
Volume	11
Issue number	4
DOIs	https://doi.org/10.1016/j.jaip.2023.01.020
State	Published - Apr 2023

Funding

Conflicts of interest: R. S. Gupta, M. Mahdavinia, C. Warren, L. A. Bilaver, and A. H. Assa’ad report other research support from the National Institutes of Health and Food Allergy Research & Education . M. Mahdavinia is also supported by the research grants from Optinose Foundation, Brinson Foundation, and the Institute for Translation Medicine in Chicago. L. A. Bilaver receives research grant support from Rho, Genentech , National Confectioners Association, Novartis , and Before Brands Inc. C. Warren reports other research support from the Sunshine Charitable Foundation; he reports receiving honoraria for the development of CME review articles on epidemiology from the American College of Allergy, Asthma, and Immunology and for workshop delivery regarding patient-reported outcomes research from the American Academy of Allergy, Asthma, and Immunology . The rest of the authors declare that they have no relevant conflicts of interest. FORWARD was supported by the National Institutes of Health (NIH) (grant number: 1R01AI130348-01A1). M. Mahdavinia is also supported by the NIH (1R03TR004005). FORWARD was supported by the National Institutes of Health (NIH) (grant number: 1R01AI130348-01A1). M. Mahdavinia is also supported by the NIH (1R03TR004005).Conflicts of interest: R. S. Gupta, M. Mahdavinia, C. Warren, L. A. Bilaver, and A. H. Assa'ad report other research support from the National Institutes of Health and Food Allergy Research & Education. M. Mahdavinia is also supported by the research grants from Optinose Foundation, Brinson Foundation, and the Institute for Translation Medicine in Chicago. L. A. Bilaver receives research grant support from Rho, Genentech, National Confectioners Association, Novartis, and Before Brands Inc. C. Warren reports other research support from the Sunshine Charitable Foundation; he reports receiving honoraria for the development of CME review articles on epidemiology from the American College of Allergy, Asthma, and Immunology and for workshop delivery regarding patient-reported outcomes research from the American Academy of Allergy, Asthma, and Immunology. The rest of the authors declare that they have no relevant conflicts of interest.

Keywords

Allergic rhinitis
Asthma
Disparities
Eczema
FORWARD
Food allergy
Race
Socioeconomic

ASJC Scopus subject areas

Immunology and Allergy

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10.1016/j.jaip.2023.01.020

Cite this

Dileep, A., Warren, C., Bilaver, L. A., Stephen, E., Andy-Nweye, A. B., Fox, S., Jiang, J., Newmark, P. J., Chura, A., Abdikarim, I., Nimmagadda, S. R., Sharma, H. P., Tobin, M. C., Assa'ad, A. H., Gupta, R. S., & Mahdavinia, M. (2023). Assessing Disparities in the Prevalence of Atopic Comorbidities Among Food-Allergic Children. Journal of Allergy and Clinical Immunology: In Practice, 11(4), 1169-1176. https://doi.org/10.1016/j.jaip.2023.01.020

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title = "Assessing Disparities in the Prevalence of Atopic Comorbidities Among Food-Allergic Children",

abstract = "Background: Previous studies have reported that Black children with food allergy (FA) have higher risk of atopic comorbidities than White children. Objective: Our study sought to understand if disparities in the prevalence of atopic comorbidities among children with FA are driven by individual and community-level socioeconomic status (SES). Methods: We analyzed data from a prospective, multicenter cohort investigating the natural history of pediatric atopy: the Food Allergy Outcomes Related to White and African American Racial Differences (FORWARD) study. A validated, multicomponent area deprivation index (ADI) percentile score was tabulated by the census block group for each subject's home address. The association of ADI with atopic comorbidities in FA was assessed via multivariable regression analysis. Results: Of the 700 children in this study, the mean ADI was 37.7 (95% confidence interval: 35.6-39.7). The mean ADI was higher in children with asthma (43.3) compared with those without asthma (31.8), which remained significant after adjusting for race (P < .0001). Children with allergic rhinitis (AR) had a higher mean ADI (39.1) compared with those without (33.4) (P = .008). ADI was associated with secondhand smoking, parents{\textquoteright} education, and household income. Black children had a higher risk for asthma after adjusting for ADI and SES-related factors. Conclusion: The independent association of ADI with asthma and AR, regardless of race, suggests a role of neighborhood-level socioeconomic deprivation in the development of these conditions among children with FA. Black children with FA remained at higher risk for asthma after adjusting for SES-related variables, which can indicate an independent risk for asthma in these children.",

keywords = "Allergic rhinitis, Asthma, Disparities, Eczema, FORWARD, Food allergy, Race, Socioeconomic",

author = "Anandu Dileep and Christopher Warren and Bilaver, {Lucy A.} and Ellen Stephen and Andy-Nweye, {Aame B.} and Susan Fox and Jialing Jiang and Newmark, {Pamela J.} and Annika Chura and Iman Abdikarim and Nimmagadda, {Sai R.} and Sharma, {Hemant P.} and Tobin, {Mary C.} and Assa'ad, {Amal H.} and Gupta, {Ruchi S.} and Mahboobeh Mahdavinia",

note = "Publisher Copyright: {\textcopyright} 2023 American Academy of Allergy, Asthma & Immunology",

year = "2023",

month = apr,

doi = "10.1016/j.jaip.2023.01.020",

language = "English (US)",

volume = "11",

pages = "1169--1176",

journal = "Journal of Allergy and Clinical Immunology: In Practice",

issn = "2213-2198",

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number = "4",

}

Dileep, A, Warren, C , Bilaver, LA, Stephen, E, Andy-Nweye, AB, Fox, S, Jiang, J, Newmark, PJ, Chura, A, Abdikarim, I, Nimmagadda, SR, Sharma, HP, Tobin, MC, Assa'ad, AH, Gupta, RS & Mahdavinia, M 2023, 'Assessing Disparities in the Prevalence of Atopic Comorbidities Among Food-Allergic Children', Journal of Allergy and Clinical Immunology: In Practice, vol. 11, no. 4, pp. 1169-1176. https://doi.org/10.1016/j.jaip.2023.01.020

TY - JOUR

T1 - Assessing Disparities in the Prevalence of Atopic Comorbidities Among Food-Allergic Children

AU - Dileep, Anandu

AU - Warren, Christopher

AU - Bilaver, Lucy A.

AU - Stephen, Ellen

AU - Andy-Nweye, Aame B.

AU - Fox, Susan

AU - Jiang, Jialing

AU - Newmark, Pamela J.

AU - Chura, Annika

AU - Abdikarim, Iman

AU - Nimmagadda, Sai R.

AU - Sharma, Hemant P.

AU - Tobin, Mary C.

AU - Assa'ad, Amal H.

AU - Gupta, Ruchi S.

AU - Mahdavinia, Mahboobeh

PY - 2023/4

Y1 - 2023/4

N2 - Background: Previous studies have reported that Black children with food allergy (FA) have higher risk of atopic comorbidities than White children. Objective: Our study sought to understand if disparities in the prevalence of atopic comorbidities among children with FA are driven by individual and community-level socioeconomic status (SES). Methods: We analyzed data from a prospective, multicenter cohort investigating the natural history of pediatric atopy: the Food Allergy Outcomes Related to White and African American Racial Differences (FORWARD) study. A validated, multicomponent area deprivation index (ADI) percentile score was tabulated by the census block group for each subject's home address. The association of ADI with atopic comorbidities in FA was assessed via multivariable regression analysis. Results: Of the 700 children in this study, the mean ADI was 37.7 (95% confidence interval: 35.6-39.7). The mean ADI was higher in children with asthma (43.3) compared with those without asthma (31.8), which remained significant after adjusting for race (P < .0001). Children with allergic rhinitis (AR) had a higher mean ADI (39.1) compared with those without (33.4) (P = .008). ADI was associated with secondhand smoking, parents’ education, and household income. Black children had a higher risk for asthma after adjusting for ADI and SES-related factors. Conclusion: The independent association of ADI with asthma and AR, regardless of race, suggests a role of neighborhood-level socioeconomic deprivation in the development of these conditions among children with FA. Black children with FA remained at higher risk for asthma after adjusting for SES-related variables, which can indicate an independent risk for asthma in these children.

AB - Background: Previous studies have reported that Black children with food allergy (FA) have higher risk of atopic comorbidities than White children. Objective: Our study sought to understand if disparities in the prevalence of atopic comorbidities among children with FA are driven by individual and community-level socioeconomic status (SES). Methods: We analyzed data from a prospective, multicenter cohort investigating the natural history of pediatric atopy: the Food Allergy Outcomes Related to White and African American Racial Differences (FORWARD) study. A validated, multicomponent area deprivation index (ADI) percentile score was tabulated by the census block group for each subject's home address. The association of ADI with atopic comorbidities in FA was assessed via multivariable regression analysis. Results: Of the 700 children in this study, the mean ADI was 37.7 (95% confidence interval: 35.6-39.7). The mean ADI was higher in children with asthma (43.3) compared with those without asthma (31.8), which remained significant after adjusting for race (P < .0001). Children with allergic rhinitis (AR) had a higher mean ADI (39.1) compared with those without (33.4) (P = .008). ADI was associated with secondhand smoking, parents’ education, and household income. Black children had a higher risk for asthma after adjusting for ADI and SES-related factors. Conclusion: The independent association of ADI with asthma and AR, regardless of race, suggests a role of neighborhood-level socioeconomic deprivation in the development of these conditions among children with FA. Black children with FA remained at higher risk for asthma after adjusting for SES-related variables, which can indicate an independent risk for asthma in these children.

KW - Allergic rhinitis

KW - Asthma

KW - Disparities

KW - Eczema

KW - FORWARD

KW - Food allergy

KW - Race

KW - Socioeconomic

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SN - 2213-2198

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JO - Journal of Allergy and Clinical Immunology: In Practice

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ER -

Assessing Disparities in the Prevalence of Atopic Comorbidities Among Food-Allergic Children

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