TY - JOUR
T1 - Assessing social vulnerabilities of salivary gland cancer care, prognosis, and treatment in the United States
AU - Bindra, Govind S.
AU - Fei-Zhang, David J.
AU - Desai, Atharva
AU - Maddalozzo, John
AU - Smith, Stephanie S.
AU - Patel, Urjeet A.
AU - Chelius, Daniel C.
AU - D'Souza, Jill N.
AU - Rastatter, Jeffrey C.
AU - Gillespie, M. Boyd
AU - Sheyn, Anthony M.
N1 - Publisher Copyright:
© 2024 The Authors. Head & Neck published by Wiley Periodicals LLC.
PY - 2024/9
Y1 - 2024/9
N2 - Background: Salivary gland cancers (SGC)-social determinants of health (SDoH) investigations are limited by narrow scopes of SGC-types and SDoH. This Social Vulnerability Index (SVI)-study hypothesized that socioeconomic status (SES) most contributed to SDoH-associated SGC-disparities. Methods: Retrospective cohort of 24 775 SGCs assessed SES, minority-language status (ML), household composition (HH), housing-transportation (HT), and composite-SDoH measured by the SVI via regressions with surveillance and survival length, late-staging presentation, and treatment (surgery, radio-, chemotherapy) receipt. Results: Increasing social vulnerability showed decreases in surveillance/survival; increased odds of advanced-presenting-stage (OR: 1.12, 95% CI: 1.07, 1.17), chemotherapy receipt (OR: 1.13, 95% CI: 1.03, 1.23); decreased odds of primary surgery (0.89, 0.84, 0.94), radiotherapy (0.91, 0.85, 0.97, p = 0.003) for SGCs. Trends were differentially correlated with SES, ML, HH, and HT-vulnerabilities. Conclusions: Through quantifying SDoH-derived SGC-disparities, the SVI can guide targeted initiatives against SDoH that elicit the most detrimental associations for specific sociodemographics.
AB - Background: Salivary gland cancers (SGC)-social determinants of health (SDoH) investigations are limited by narrow scopes of SGC-types and SDoH. This Social Vulnerability Index (SVI)-study hypothesized that socioeconomic status (SES) most contributed to SDoH-associated SGC-disparities. Methods: Retrospective cohort of 24 775 SGCs assessed SES, minority-language status (ML), household composition (HH), housing-transportation (HT), and composite-SDoH measured by the SVI via regressions with surveillance and survival length, late-staging presentation, and treatment (surgery, radio-, chemotherapy) receipt. Results: Increasing social vulnerability showed decreases in surveillance/survival; increased odds of advanced-presenting-stage (OR: 1.12, 95% CI: 1.07, 1.17), chemotherapy receipt (OR: 1.13, 95% CI: 1.03, 1.23); decreased odds of primary surgery (0.89, 0.84, 0.94), radiotherapy (0.91, 0.85, 0.97, p = 0.003) for SGCs. Trends were differentially correlated with SES, ML, HH, and HT-vulnerabilities. Conclusions: Through quantifying SDoH-derived SGC-disparities, the SVI can guide targeted initiatives against SDoH that elicit the most detrimental associations for specific sociodemographics.
KW - epidemiology
KW - head and neck cancer
KW - salivary gland cancer
KW - social determinants of health
KW - social vulnerability
UR - http://www.scopus.com/inward/record.url?scp=85191156218&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85191156218&partnerID=8YFLogxK
U2 - 10.1002/hed.27783
DO - 10.1002/hed.27783
M3 - Article
C2 - 38651501
AN - SCOPUS:85191156218
SN - 1043-3074
VL - 46
SP - 2152
EP - 2166
JO - Head and Neck
JF - Head and Neck
IS - 9
ER -
