Assessment of age-related decline of neurovascular coupling responses by functional near-infrared spectroscopy (fNIRS) in humans

Tamas Csipo, Peter Mukli, Agnes Lipecz, Stefano Tarantini, Dhay Bahadli, Osamah Abdulhussein, Cameron Owens, Tamas Kiss, Priya Balasubramanian, Ádám Nyúl-Tóth, Rachel A. Hand, Valeriya Yabluchanska, Farzaneh A. Sorond, Anna Csiszar, Zoltan Ungvari, Andriy Yabluchanskiy*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


Preclinical studies provide strong evidence that age-related impairment of neurovascular coupling (NVC) plays a causal role in the pathogenesis of vascular cognitive impairment (VCI). NVC is a critical homeostatic mechanism in the brain, responsible for adjustment of local cerebral blood flow to the energetic needs of the active neuronal tissue. Recent progress in geroscience has led to the identification of critical cellular and molecular mechanisms involved in neurovascular aging, identifying these pathways as targets for intervention. In order to translate the preclinical findings to humans, there is a need to assess NVC in geriatric patients as an endpoint in clinical studies. Functional near-infrared spectroscopy (fNIRS) is a non-invasive neuroimaging technique that enables the investigation of local changes in cerebral blood flow, quantifying task-related changes in oxygenated and deoxygenated hemoglobin concentrations. In the present overview, the basic principles of fNIRS are introduced and the application of this technique to assess NVC in older adults with implications for the design of studies on the mechanistic underpinnings of VCI is discussed.

Original languageEnglish (US)
Pages (from-to)495-509
Number of pages15
Issue number5
StatePublished - Oct 1 2019


  • Aging
  • Cognitive aging
  • Functional near-infrared spectroscopy
  • Neurovascular coupling
  • VCI
  • VCID
  • Vascular cognitive impairment and dementia
  • fNIRS

ASJC Scopus subject areas

  • Aging
  • veterinary (miscalleneous)
  • Complementary and alternative medicine
  • Geriatrics and Gerontology
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Assessment of age-related decline of neurovascular coupling responses by functional near-infrared spectroscopy (fNIRS) in humans'. Together they form a unique fingerprint.

Cite this