Assessment of blood supply in superficial tissue by polarization-gated elastic light-scattering spectroscopy

Michael P. Siegel; Young L. Kim; Hemant K. Roy; Ramesh K. Wali; Vadim Backman

doi:10.1364/AO.45.000335

Assessment of blood supply in superficial tissue by polarization-gated elastic light-scattering spectroscopy

Michael P. Siegel^*, Young L. Kim, Hemant K. Roy, Ramesh K. Wali, Vadim Backman

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

We report the feasibility of monitoring both hemoglobin oxygen saturation and hemoglobin concentration in the superficial layer of tissue using polarization-gated elastic light-scattering spectroscopy. We detail our analysis technique, the experimental validation of our analysis, and the detection of an early increase in blood supply to the superficial layer of colon tissue in human patients with colonic adenomas as well as in an animal model of colon carcinogenesis. To the best of our knowledge, this study represents the first evidence that polarization gating can be used as a spectroscopic tool to quantify hemoglobin concentration as well as oxygen saturation in the uppermost tissue layer.

Original language	English (US)
Pages (from-to)	335-342
Number of pages	8
Journal	Applied optics
Volume	45
Issue number	2
DOIs	https://doi.org/10.1364/AO.45.000335
State	Published - Jan 10 2006

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Engineering (miscellaneous)
Electrical and Electronic Engineering

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abstract = "We report the feasibility of monitoring both hemoglobin oxygen saturation and hemoglobin concentration in the superficial layer of tissue using polarization-gated elastic light-scattering spectroscopy. We detail our analysis technique, the experimental validation of our analysis, and the detection of an early increase in blood supply to the superficial layer of colon tissue in human patients with colonic adenomas as well as in an animal model of colon carcinogenesis. To the best of our knowledge, this study represents the first evidence that polarization gating can be used as a spectroscopic tool to quantify hemoglobin concentration as well as oxygen saturation in the uppermost tissue layer.",

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AU - Wali, Ramesh K.

AU - Backman, Vadim

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Y1 - 2006/1/10

N2 - We report the feasibility of monitoring both hemoglobin oxygen saturation and hemoglobin concentration in the superficial layer of tissue using polarization-gated elastic light-scattering spectroscopy. We detail our analysis technique, the experimental validation of our analysis, and the detection of an early increase in blood supply to the superficial layer of colon tissue in human patients with colonic adenomas as well as in an animal model of colon carcinogenesis. To the best of our knowledge, this study represents the first evidence that polarization gating can be used as a spectroscopic tool to quantify hemoglobin concentration as well as oxygen saturation in the uppermost tissue layer.

AB - We report the feasibility of monitoring both hemoglobin oxygen saturation and hemoglobin concentration in the superficial layer of tissue using polarization-gated elastic light-scattering spectroscopy. We detail our analysis technique, the experimental validation of our analysis, and the detection of an early increase in blood supply to the superficial layer of colon tissue in human patients with colonic adenomas as well as in an animal model of colon carcinogenesis. To the best of our knowledge, this study represents the first evidence that polarization gating can be used as a spectroscopic tool to quantify hemoglobin concentration as well as oxygen saturation in the uppermost tissue layer.

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Assessment of blood supply in superficial tissue by polarization-gated elastic light-scattering spectroscopy

Abstract

ASJC Scopus subject areas

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