Abstract
Objectives: To assess body composition in patients with non-small cell lung cancer (NSCLC) and colorectal cancer using whole-body MRI and relate this to clinical outcomes. Methods: 53 patients with NSCLC (28 males, 25 females; mean age 66.9) and 74 patients with colorectal cancer (42 males, 32 females; mean age 62.9) underwent staging whole-body MRI scans, which were post-processed to derive fat mass (FM), fat free mass (FFM) and skeletal muscle (SM) indices and SM fat fraction (FF). These were compared between the two cancer cohorts using two-sided t-tests and the chi-squared test. Measurements of body composition were correlated with outcomes including length of hospital stay, metastatic status and mortality. Results: Patients with NSCLC had significantly lower FFM (p = 0.0071) and SM (p = 0.0084) indices. Mean SM FF was greater in patients with NSCLC (p = 0.0124) and was associated with longer hospital stay (p = 0.035). There was no significant relationship between FM, FFM and SM indices and length of hospital stay, metastatic status or mortality. Conclusions: Patients with NSCLC had lower FFM and SM indices than patients with colorectal cancer and greater SMFF, indicating lower SM mass with fatty infiltration. These findings reflect differences in the phenotype of the two groups and suggest patients with lung cancer are more likely to require additional nutritional support. Advances in knowledge: Body composition differs between NSCLC and colorectal cancer. Patients with NSCLC have both a reduced SM mass and greater SM FF suggesting that they are more nutritionally deplete than patients with colorectal cancer.
| Original language | English (US) |
|---|---|
| Article number | 20210048 |
| Journal | BJR Open |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| State | Published - Nov 24 2021 |
Funding
This work was supported by the National Institute of Health Research health technology assessment NIHR HTA programme (grant number 10/68/01)NS, MHC and ST receive funding from the UCL/UCLH BRC. TB is an NIHR clinical lecturer. ST is an NIHR senior investigator. This work was undertaken at UCLH/UCL, which receives funding from the UK Department of Health\u2019s the National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) funding scheme. The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, NETSCC or the HTA programme or the Department of Health
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
