Assessment of coagulation system activation using spot urine measurements

S. E. Lind*, S. Goldshteyn, C. P. Barry, J. R. Lindquist, A. A. Piergies, T. Rosen, Joseph R Schneider, D. H. Shevrin, J. A. Caprini

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Coagulation system activation is most commonly assessed by measuring levels of one or more proteins in peripheral blood. Because faulty blood- drawing can cause activation of the coagulation system, artifactual elevations of such markers have been reported. We have therefore investigated the possibility of using randomly collected ('spot') urine samples as a non- invasive means of assessing the state of coagulation system activation. Using a commercially available enzyme-linked immunosorbent assay kit designed to measure plasma levels of fragment 1+ 2, we found immunoreactive fragment 2 in healthy control subjects, and significantly increased levels in diabetic and non-diabetic pregnant subjects, and patients with venous thromboembolism, prostate cancer, and diabetes. Measurements of excretion of immunoreactive fragment 2 are worth further study as an adjunct or alternative to plasma- based assays designed to detect or quantify coagulation system activation.

Original languageEnglish (US)
Pages (from-to)285-289
Number of pages5
JournalBlood Coagulation and Fibrinolysis
Volume10
Issue number5
StatePublished - Aug 23 1999

Keywords

  • Blood coagulation
  • Prothrombin
  • Urine

ASJC Scopus subject areas

  • Hematology

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