Assessment of Intrafraction Mediastinal and Hilar Lymph Node Movement and Comparison to Lung Tumor Motion Using Four-Dimensional CT

Eric D. Donnelly, Parag J. Parikh*, Wei Lu, Tianyu Zhao, Kristen Lechleiter, Michelle Nystrom, James P. Hubenschmidt, Daniel A. Low, Jeffrey D. Bradley

*Corresponding author for this work

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Purpose: To quantify the amount of free-breathing motion measured using Four-dimensional (4D) CT scans of mediastinal and hilar lymph nodes and to compare this motion to the primary lung tumor motion. Methods and Materials: Twenty patients with primary lung cancer, radiographically positive lymph nodes, and prior 4D CT scans were retrospectively analyzed. The 4D CT data sets were divided into four respiratory phases, and the primary tumor and radiographically positive nodes were contoured. Geometric and volumetric analysis was performed to analyze the motion of the primary tumors and the lymph nodes. Results: The mean lymph node motion was 2.6 mm in the mediolateral direction, 2.5 mm in the anterior-posterior direction, and 5.2 mm in the cranial-caudal direction with a maximum of 14.4 mm. All lymph nodes were found to move inferiorly during inspiration, with 12.5% of nodes moving more than 1 cm. Lymph nodes located below the carina showed significantly more motion than those above the carina (p = 0.01). In comparing the primary tumor motion to the lymph node motion, no correlation was identified. Conclusions: Four-dimensional CT scans can be used to measure the motion of the primary lung tumor and pathologic lymph nodes encountered during the respiratory cycle. Both the primary lung tumor and the lymph node must to be examined to assess their individual degree of motion. This study demonstrates the need for individualized plans to assess the heterogeneous motion encountered in both primary lung tumors and among lymph node stations.

Original languageEnglish (US)
Pages (from-to)580-588
Number of pages9
JournalInternational Journal of Radiation Oncology Biology Physics
Volume69
Issue number2
DOIs
StatePublished - Oct 1 2007

Keywords

  • Four-dimensional computed tomography
  • Lung cancer
  • Mediastinal lymph nodes
  • Radiation therapy

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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