Assessment of musculoskeletal function and mood in haemophilia A adolescents: A cross-sectional study

T. H. Hassan*, M. A. Badr, N. R A Fattah, S. M. Badawy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Haemophilia A is characterized by the occurrence of frequent spontaneous intra-articular and intramuscular bleeding. If inadequately treated, it results in progressive damage to joints and muscles leading to crippling deformities and musculoskeletal dysfunction. These complications result in lifelong chronic pain and disability that may greatly affect the patients' mood. We aimed to evaluate the musculoskeletal function in our haemophilia A patients and its correlation to depressed mood in these patients and determine the impact of degree of factor VIII deficiency, different replacement therapy regimens and frequency of hemarthrosis, on both musculoskeletal function and mood. A cross-sectional study was carried out on 50 adolescent haemophilia A patients. Musculoskeletal function was assessed using Functional Independence Score for Hemophilia (FISH) and mood status was assessed using Beck Depression Inventory-Short Form (BDI-SF). The mean FISH score was 23.32±4.69 (range 13-28) and the tasks that obtained lower scores were step climbing, squatting and walking. Of our 50 patients included, 16(32%) were not depressed, 18(36%) were with mild depression, 11(22%) were with moderate depression and 5(10%) were with severe depression. There was a highly significant negative correlation between mean FISH score and mean BDI-SF score (P<0.001). The better the replacement therapy regimen, the better the musculoskeletal function that could be obtained in haemophilia A patients and the better the mood.

Original languageEnglish (US)
Pages (from-to)683-688
Number of pages6
Issue number4
StatePublished - Jul 1 2011


  • Adolescents
  • BDI
  • FISH
  • Haemophilia A
  • Mood
  • Musculoskeletal

ASJC Scopus subject areas

  • Hematology
  • Genetics(clinical)

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