Assessment of patient-reported clinical outcome in pancreatic and other hepatobiliary cancers: The FACT Hepatobiliary Symptom Index

Susan Yount*, David Cella, Kimberly Webster, Nancy Heffernan, Chih Hung Chang, Linda Odom, Renilt Van Gool

*Corresponding author for this work

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

This study's aim was to develop and validate a symptom index derived from the Functional Assessment of Cancer Therapy-Hepatobiliary, a questionnaire measuring general and hepatobiliary disease specific aspects of quality of life. The item pool was narrowed to 26 questions that assess symptoms and function. Each of 95 hepatobiliary cancer experts narrowed the list to 5 of the most important to attend to when treating advanced hepatobiliary disease. Eight symptoms were endorsed by more than 20% of the experts (3 pain, 2 fatigue, nausea, weight loss, jaundice) and were named the FACT-Hepatobiliary Symptom Index-8 (FHSI-8). Among 51 hepatobiliary cancer patients, the FHSI-8 showed good internal consistency (0.79), test-retest reliability (r = 0.86), strong association with mood (r = -0.56), and patient differentiation by ECOG Performance Status Rating ( P < 0.0001) and treatment status ( P = 0.057). Symptom scaling in diseases such as hepatobiliary cancer is feasible and may provide an efficient, clinically-relevant endpoint for following groups over time.

Original languageEnglish (US)
Pages (from-to)32-44
Number of pages13
JournalJournal of Pain and Symptom Management
Volume24
Issue number1
DOIs
StatePublished - Aug 28 2002

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Neoplasms
Jaundice
Reproducibility of Results
Nausea
Fatigue
Weight Loss
Quality of Life
Pain
Patient Reported Outcome Measures
Therapeutics
Surveys and Questionnaires

Keywords

  • Cancer
  • Hepatobiliary cancer
  • Quality of life
  • Symptoms

ASJC Scopus subject areas

  • Nursing(all)
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

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title = "Assessment of patient-reported clinical outcome in pancreatic and other hepatobiliary cancers: The FACT Hepatobiliary Symptom Index",
abstract = "This study's aim was to develop and validate a symptom index derived from the Functional Assessment of Cancer Therapy-Hepatobiliary, a questionnaire measuring general and hepatobiliary disease specific aspects of quality of life. The item pool was narrowed to 26 questions that assess symptoms and function. Each of 95 hepatobiliary cancer experts narrowed the list to 5 of the most important to attend to when treating advanced hepatobiliary disease. Eight symptoms were endorsed by more than 20{\%} of the experts (3 pain, 2 fatigue, nausea, weight loss, jaundice) and were named the FACT-Hepatobiliary Symptom Index-8 (FHSI-8). Among 51 hepatobiliary cancer patients, the FHSI-8 showed good internal consistency (0.79), test-retest reliability (r = 0.86), strong association with mood (r = -0.56), and patient differentiation by ECOG Performance Status Rating ( P < 0.0001) and treatment status ( P = 0.057). Symptom scaling in diseases such as hepatobiliary cancer is feasible and may provide an efficient, clinically-relevant endpoint for following groups over time.",
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Assessment of patient-reported clinical outcome in pancreatic and other hepatobiliary cancers : The FACT Hepatobiliary Symptom Index. / Yount, Susan; Cella, David; Webster, Kimberly; Heffernan, Nancy; Chang, Chih Hung; Odom, Linda; Van Gool, Renilt.

In: Journal of Pain and Symptom Management, Vol. 24, No. 1, 28.08.2002, p. 32-44.

Research output: Contribution to journalArticle

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