Assessment of pressure, angle, and temporal effects on polarization-gated spectroscopic probe measurements

Sarah Ruderman*, Valentina Stoyneva, Andrew J. Gomes, Jeremy D. Rogers, Vadim Backman

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Noninvasive and real-time analysis of tissue properties, in particular, the quantitative assessment of blood content and light scattering properties of mucosa is useful in a wide variety of applications. However, the nature of interactions between contact fiber-optic probes and the tissue surface presents a challenging problem with respect to the variability of in vivo measurements, for example affects due to variations in the pressure and angle of the probe tip on the tissue surface. Previously, pressure and angle effects have been investigated for other modalities (i.e. diffuse reflectance and Raman spectroscopy). We present an evaluation of this variability, as well as the length of time in contact with tissue for polarization-gated spectroscopy. The evaluation is based on the quantification of mucosal blood content at superficial depths (within 100 to 200 microns of tissue surface) for in vivo measurements of oral mucosa. Measurements are presented for different pressures, angles and time scales and the variability due to these factors is assessed.

Original languageEnglish (US)
Title of host publicationDesign and Quality for Biomedical Technologies III
Volume7556
DOIs
StatePublished - May 6 2010
EventDesign and Quality for Biomedical Technologies III - San Francisco, CA, United States
Duration: Jan 25 2010Jan 26 2010

Other

OtherDesign and Quality for Biomedical Technologies III
CountryUnited States
CitySan Francisco, CA
Period1/25/101/26/10

Keywords

  • Angle effects
  • Fiber-optic probes
  • Polarization-gating spectroscopy
  • Pressure effects
  • Probe contact
  • Temporal effects

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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