Assessment of pressure, angle, and temporal effects on polarization-gated spectroscopic probe measurements

Sarah Ruderman; Valentina Stoyneva; Andrew J. Gomes; Jeremy D. Rogers; Vadim Backman

doi:10.1117/12.842857

Assessment of pressure, angle, and temporal effects on polarization-gated spectroscopic probe measurements

Sarah Ruderman^*, Valentina Stoyneva, Andrew J. Gomes, Jeremy D. Rogers, Vadim Backman

^*Corresponding author for this work

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Noninvasive and real-time analysis of tissue properties, in particular, the quantitative assessment of blood content and light scattering properties of mucosa is useful in a wide variety of applications. However, the nature of interactions between contact fiber-optic probes and the tissue surface presents a challenging problem with respect to the variability of in vivo measurements, for example affects due to variations in the pressure and angle of the probe tip on the tissue surface. Previously, pressure and angle effects have been investigated for other modalities (i.e. diffuse reflectance and Raman spectroscopy). We present an evaluation of this variability, as well as the length of time in contact with tissue for polarization-gated spectroscopy. The evaluation is based on the quantification of mucosal blood content at superficial depths (within 100 to 200 microns of tissue surface) for in vivo measurements of oral mucosa. Measurements are presented for different pressures, angles and time scales and the variability due to these factors is assessed.

Original language	English (US)
Title of host publication	Design and Quality for Biomedical Technologies III
Volume	7556
DOIs	https://doi.org/10.1117/12.842857
State	Published - May 6 2010
Event	Design and Quality for Biomedical Technologies III - San Francisco, CA, United States Duration: Jan 25 2010 → Jan 26 2010

Other

Other	Design and Quality for Biomedical Technologies III
Country	United States
City	San Francisco, CA
Period	1/25/10 → 1/26/10

Keywords

Angle effects
Fiber-optic probes
Polarization-gating spectroscopy
Pressure effects
Probe contact
Temporal effects

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

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Cite this

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title = "Assessment of pressure, angle, and temporal effects on polarization-gated spectroscopic probe measurements",

abstract = "Noninvasive and real-time analysis of tissue properties, in particular, the quantitative assessment of blood content and light scattering properties of mucosa is useful in a wide variety of applications. However, the nature of interactions between contact fiber-optic probes and the tissue surface presents a challenging problem with respect to the variability of in vivo measurements, for example affects due to variations in the pressure and angle of the probe tip on the tissue surface. Previously, pressure and angle effects have been investigated for other modalities (i.e. diffuse reflectance and Raman spectroscopy). We present an evaluation of this variability, as well as the length of time in contact with tissue for polarization-gated spectroscopy. The evaluation is based on the quantification of mucosal blood content at superficial depths (within 100 to 200 microns of tissue surface) for in vivo measurements of oral mucosa. Measurements are presented for different pressures, angles and time scales and the variability due to these factors is assessed.",

keywords = "Angle effects, Fiber-optic probes, Polarization-gating spectroscopy, Pressure effects, Probe contact, Temporal effects",

author = "Sarah Ruderman and Valentina Stoyneva and Gomes, {Andrew J.} and Rogers, {Jeremy D.} and Vadim Backman",

year = "2010",

month = may,

day = "6",

doi = "10.1117/12.842857",

language = "English (US)",

isbn = "9780819479525",

volume = "7556",

booktitle = "Design and Quality for Biomedical Technologies III",

note = "Design and Quality for Biomedical Technologies III ; Conference date: 25-01-2010 Through 26-01-2010",

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Ruderman, S, Stoyneva, V, Gomes, AJ, Rogers, JD & Backman, V 2010, Assessment of pressure, angle, and temporal effects on polarization-gated spectroscopic probe measurements. in Design and Quality for Biomedical Technologies III. vol. 7556, 75560K, Design and Quality for Biomedical Technologies III, San Francisco, CA, United States, 1/25/10. https://doi.org/10.1117/12.842857

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AU - Ruderman, Sarah

AU - Stoyneva, Valentina

AU - Gomes, Andrew J.

AU - Rogers, Jeremy D.

AU - Backman, Vadim

PY - 2010/5/6

Y1 - 2010/5/6

N2 - Noninvasive and real-time analysis of tissue properties, in particular, the quantitative assessment of blood content and light scattering properties of mucosa is useful in a wide variety of applications. However, the nature of interactions between contact fiber-optic probes and the tissue surface presents a challenging problem with respect to the variability of in vivo measurements, for example affects due to variations in the pressure and angle of the probe tip on the tissue surface. Previously, pressure and angle effects have been investigated for other modalities (i.e. diffuse reflectance and Raman spectroscopy). We present an evaluation of this variability, as well as the length of time in contact with tissue for polarization-gated spectroscopy. The evaluation is based on the quantification of mucosal blood content at superficial depths (within 100 to 200 microns of tissue surface) for in vivo measurements of oral mucosa. Measurements are presented for different pressures, angles and time scales and the variability due to these factors is assessed.

AB - Noninvasive and real-time analysis of tissue properties, in particular, the quantitative assessment of blood content and light scattering properties of mucosa is useful in a wide variety of applications. However, the nature of interactions between contact fiber-optic probes and the tissue surface presents a challenging problem with respect to the variability of in vivo measurements, for example affects due to variations in the pressure and angle of the probe tip on the tissue surface. Previously, pressure and angle effects have been investigated for other modalities (i.e. diffuse reflectance and Raman spectroscopy). We present an evaluation of this variability, as well as the length of time in contact with tissue for polarization-gated spectroscopy. The evaluation is based on the quantification of mucosal blood content at superficial depths (within 100 to 200 microns of tissue surface) for in vivo measurements of oral mucosa. Measurements are presented for different pressures, angles and time scales and the variability due to these factors is assessed.

KW - Angle effects

KW - Fiber-optic probes

KW - Polarization-gating spectroscopy

KW - Pressure effects

KW - Probe contact

KW - Temporal effects

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