Assessment of radiation mediated gene therapy via multi-modality imaging

C. R. Haney; A. Parasca; K. Ichikawa; M. Elas; M. Zamora; X. Fan; G. S. Karczmar; H. J. Mauceri; R. R. Weichselbaum; H. J. Halpern; C. A. Pelizzari

Assessment of radiation mediated gene therapy via multi-modality imaging

C. R. Haney^*, A. Parasca, K. Ichikawa, M. Elas, M. Zamora, X. Fan, G. S. Karczmar, H. J. Mauceri, R. R. Weichselbaum, H. J. Halpern, C. A. Pelizzari

^*Corresponding author for this work

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Imaging techniques are under development which are intended to facilitate early analysis of spatial patterns of tumor response to combined radiation and antivascular gene therapy. We present initial results demonstrating treatment related changes of vascular permeability and blood volume maps using MRI, and tissue oxygenation measurements using electron paramagnetic resonance imaging (EPRI). Using a modified Kety model, the volume fraction accessible to the contrast agent was significantly greater in the tumor (0.81±0.11), compared to muscle (0.20±0.00, p < 0.05). However, the two compartment model is probably not able to account for accumulation of contrast agent in the tumor. A three compartment model may improve fitting.

Original language	English (US)
Title of host publication	2004 2nd IEEE International Symposium on Biomedical Imaging
Subtitle of host publication	Macro to Nano
Pages	1549-1552
Number of pages	4
State	Published - Dec 1 2004
Event	2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano - Arlington, VA, United States Duration: Apr 15 2004 → Apr 18 2004

Publication series

Name	2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
Volume	2

Other

Other	2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
Country/Territory	United States
City	Arlington, VA
Period	4/15/04 → 4/18/04

ASJC Scopus subject areas

General Engineering

Cite this

Haney, C. R., Parasca, A., Ichikawa, K., Elas, M., Zamora, M., Fan, X., Karczmar, G. S., Mauceri, H. J., Weichselbaum, R. R., Halpern, H. J., & Pelizzari, C. A. (2004). Assessment of radiation mediated gene therapy via multi-modality imaging. In 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano (pp. 1549-1552). (2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano; Vol. 2).

@inproceedings{6871be0f42c443d4b2df367fbb4f9cf0,

title = "Assessment of radiation mediated gene therapy via multi-modality imaging",

abstract = "Imaging techniques are under development which are intended to facilitate early analysis of spatial patterns of tumor response to combined radiation and antivascular gene therapy. We present initial results demonstrating treatment related changes of vascular permeability and blood volume maps using MRI, and tissue oxygenation measurements using electron paramagnetic resonance imaging (EPRI). Using a modified Kety model, the volume fraction accessible to the contrast agent was significantly greater in the tumor (0.81±0.11), compared to muscle (0.20±0.00, p < 0.05). However, the two compartment model is probably not able to account for accumulation of contrast agent in the tumor. A three compartment model may improve fitting.",

author = "Haney, {C. R.} and A. Parasca and K. Ichikawa and M. Elas and M. Zamora and X. Fan and Karczmar, {G. S.} and Mauceri, {H. J.} and Weichselbaum, {R. R.} and Halpern, {H. J.} and Pelizzari, {C. A.}",

year = "2004",

month = dec,

day = "1",

language = "English (US)",

isbn = "0780383885",

series = "2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano",

pages = "1549--1552",

booktitle = "2004 2nd IEEE International Symposium on Biomedical Imaging",

note = "2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano ; Conference date: 15-04-2004 Through 18-04-2004",

}

Haney, CR, Parasca, A, Ichikawa, K, Elas, M, Zamora, M, Fan, X, Karczmar, GS, Mauceri, HJ, Weichselbaum, RR, Halpern, HJ & Pelizzari, CA 2004, Assessment of radiation mediated gene therapy via multi-modality imaging. in 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano. 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano, vol. 2, pp. 1549-1552, 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano, Arlington, VA, United States, 4/15/04.

Assessment of radiation mediated gene therapy via multi-modality imaging. / Haney, C. R.; Parasca, A.; Ichikawa, K. et al.
2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano. 2004. p. 1549-1552 (2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano; Vol. 2).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Assessment of radiation mediated gene therapy via multi-modality imaging

AU - Haney, C. R.

AU - Parasca, A.

AU - Ichikawa, K.

AU - Elas, M.

AU - Zamora, M.

AU - Fan, X.

AU - Karczmar, G. S.

AU - Mauceri, H. J.

AU - Weichselbaum, R. R.

AU - Halpern, H. J.

AU - Pelizzari, C. A.

PY - 2004/12/1

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N2 - Imaging techniques are under development which are intended to facilitate early analysis of spatial patterns of tumor response to combined radiation and antivascular gene therapy. We present initial results demonstrating treatment related changes of vascular permeability and blood volume maps using MRI, and tissue oxygenation measurements using electron paramagnetic resonance imaging (EPRI). Using a modified Kety model, the volume fraction accessible to the contrast agent was significantly greater in the tumor (0.81±0.11), compared to muscle (0.20±0.00, p < 0.05). However, the two compartment model is probably not able to account for accumulation of contrast agent in the tumor. A three compartment model may improve fitting.

AB - Imaging techniques are under development which are intended to facilitate early analysis of spatial patterns of tumor response to combined radiation and antivascular gene therapy. We present initial results demonstrating treatment related changes of vascular permeability and blood volume maps using MRI, and tissue oxygenation measurements using electron paramagnetic resonance imaging (EPRI). Using a modified Kety model, the volume fraction accessible to the contrast agent was significantly greater in the tumor (0.81±0.11), compared to muscle (0.20±0.00, p < 0.05). However, the two compartment model is probably not able to account for accumulation of contrast agent in the tumor. A three compartment model may improve fitting.

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M3 - Conference contribution

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T3 - 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano

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T2 - 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano

Y2 - 15 April 2004 through 18 April 2004

ER -

Assessment of radiation mediated gene therapy via multi-modality imaging

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