Assessment of Venous Thrombosis in Animal Models

Steven P. Grover, Colin E. Evans, Ashish S. Patel, Bijan Modarai, Prakash Saha*, Alberto Smith

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Deep vein thrombosis and common complications, including pulmonary embolism and post-thrombotic syndrome, represent a major source of morbidity and mortality worldwide. Experimental models of venous thrombosis have provided considerable insight into the cellular and molecular mechanisms that regulate thrombus formation and subsequent resolution. Here, we critically appraise the ex vivo and in vivo techniques used to assess venous thrombosis in these models. Particular attention is paid to imaging modalities, including magnetic resonance imaging, micro-computed tomography, and high-frequency ultrasound that facilitate longitudinal assessment of thrombus size and composition.

Original languageEnglish (US)
Pages (from-to)245-252
Number of pages8
JournalArteriosclerosis, thrombosis, and vascular biology
Volume36
Issue number2
DOIs
StatePublished - Feb 1 2016

Keywords

  • histological techniques
  • models, animal
  • molecular imaging
  • venous thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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