Assessment of viscous energy loss and the association with three-dimensional vortex ring formation in left ventricular inflow: In vivo evaluation using four-dimensional flow MRI

Mohammed Elbaz*, Rob J. van der Geest, Emmeline E. Calkoen, Albert de Roos, Boudewijn P.F. Lelieveldt, Arno A.W. Roest, Jos J.M. Westenberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Purpose: To evaluate viscous energy loss and the association with three-dimensional (3D) vortex ring formation in left ventricular (LV) blood flow during diastolic filling. Theory and Methods: Thirty healthy volunteers were compared with 32 patients with corrected atrioventricular septal defect as unnatural mitral valve morphology and inflow are common in these patients. 4DFlow MRI was acquired from which 3D vortex ring formation was identified in LV blood flow at peak early (E)-filling and late (A)-filling and characterized by its presence/absence, orientation, and position from the lateral wall. Viscous energy loss was computed over E-filling, A-filling, and complete diastole using the Navier-Stokes energy equations. Results: Compared with healthy volunteers, viscous energy loss was significantly elevated in patients with disturbed vortex ring formation as characterized by a significantly inclined orientation and/or position closer to the lateral wall. Highest viscous energy loss was found in patients without a ring-shaped vortex during E-filling (on average more than double compared with patients with ring-shape vortex, P < 0.003). Altered A-filling vortex ring formation was associated with significant increase in total viscous energy loss over diastole even in the presence of normal E-filling vortex ring. Conclusion: Altered vortex ring formation during LV filling is associated with increased viscous energy loss. Magn Reson Med 77:794–805, 2017.

Original languageEnglish (US)
Pages (from-to)794-805
Number of pages12
JournalMagnetic resonance in medicine
Volume77
Issue number2
DOIs
StatePublished - Feb 1 2017

Keywords

  • 4DFlow MRI
  • atrioventricular septal defect
  • cardiac vortex flow
  • diastolic function
  • viscous energy loss

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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