Assignment of the human heart tetrodotoxin-resistant voltage-gated Na+ channel α-subunit gene (SCN5A) to band 3p21

A. L. George*, T. A. Varkony, H. A. Drabkin, J. Han, J. F. Knops, W. H. Finley, G. B. Brown, D. C. Ward, M. Haas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

105 Scopus citations


The chromosomal location of SCN5A, the gene encoding the principal voltage-gated Na+ channel expressed in human heart, has been determined by three independent methodologies: Somatic cell hybrid mapping, chromosomal micro-dissection-polymerase chain reaction, and fluorescence in situ hybridization. The SCN5A gene was assigned to the short arm of chromosome 3 (band 3p21) by all three approaches. These data are further evidence that striated muscle Na+ channel genes are dispersed in the genome.

Original languageEnglish (US)
Pages (from-to)67-70
Number of pages4
JournalCytogenetic and Genome Research
Issue number1-2
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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