Assignment of the human heart tetrodotoxin-resistant voltage-gated Na+ channel α-subunit gene (SCN5A) to band 3p21

A. L. George; T. A. Varkony; H. A. Drabkin; J. Han; J. F. Knops; W. H. Finley; G. B. Brown; D. C. Ward; M. Haas

doi:10.1159/000133892

Assignment of the human heart tetrodotoxin-resistant voltage-gated Na⁺ channel α-subunit gene (SCN5A) to band 3p21

A. L. George^*, T. A. Varkony, H. A. Drabkin, J. Han, J. F. Knops, W. H. Finley, G. B. Brown, D. C. Ward, M. Haas

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

The chromosomal location of SCN5A, the gene encoding the principal voltage-gated Na⁺ channel expressed in human heart, has been determined by three independent methodologies: Somatic cell hybrid mapping, chromosomal micro-dissection-polymerase chain reaction, and fluorescence in situ hybridization. The SCN5A gene was assigned to the short arm of chromosome 3 (band 3p21) by all three approaches. These data are further evidence that striated muscle Na⁺ channel genes are dispersed in the genome.

Original language	English (US)
Pages (from-to)	67-70
Number of pages	4
Journal	Cytogenetics and Cell Genetics
Volume	68
Issue number	1-2
DOIs	https://doi.org/10.1159/000133892
State	Published - 1995

ASJC Scopus subject areas

Genetics
Cell Biology

Access to Document

10.1159/000133892

Cite this

@article{804764061877474aa19f3ef1b72889f5,

title = "Assignment of the human heart tetrodotoxin-resistant voltage-gated Na+ channel α-subunit gene (SCN5A) to band 3p21",

abstract = "The chromosomal location of SCN5A, the gene encoding the principal voltage-gated Na+ channel expressed in human heart, has been determined by three independent methodologies: Somatic cell hybrid mapping, chromosomal micro-dissection-polymerase chain reaction, and fluorescence in situ hybridization. The SCN5A gene was assigned to the short arm of chromosome 3 (band 3p21) by all three approaches. These data are further evidence that striated muscle Na+ channel genes are dispersed in the genome.",

author = "George, {A. L.} and Varkony, {T. A.} and Drabkin, {H. A.} and J. Han and Knops, {J. F.} and Finley, {W. H.} and Brown, {G. B.} and Ward, {D. C.} and M. Haas",

year = "1995",

doi = "10.1159/000133892",

language = "English (US)",

volume = "68",

pages = "67--70",

journal = "Cytogenetic and Genome Research",

issn = "1424-8581",

publisher = "S. Karger AG",

number = "1-2",

}

TY - JOUR

T1 - Assignment of the human heart tetrodotoxin-resistant voltage-gated Na+ channel α-subunit gene (SCN5A) to band 3p21

AU - George, A. L.

AU - Varkony, T. A.

AU - Drabkin, H. A.

AU - Han, J.

AU - Knops, J. F.

AU - Finley, W. H.

AU - Brown, G. B.

AU - Ward, D. C.

AU - Haas, M.

PY - 1995

Y1 - 1995

N2 - The chromosomal location of SCN5A, the gene encoding the principal voltage-gated Na+ channel expressed in human heart, has been determined by three independent methodologies: Somatic cell hybrid mapping, chromosomal micro-dissection-polymerase chain reaction, and fluorescence in situ hybridization. The SCN5A gene was assigned to the short arm of chromosome 3 (band 3p21) by all three approaches. These data are further evidence that striated muscle Na+ channel genes are dispersed in the genome.

AB - The chromosomal location of SCN5A, the gene encoding the principal voltage-gated Na+ channel expressed in human heart, has been determined by three independent methodologies: Somatic cell hybrid mapping, chromosomal micro-dissection-polymerase chain reaction, and fluorescence in situ hybridization. The SCN5A gene was assigned to the short arm of chromosome 3 (band 3p21) by all three approaches. These data are further evidence that striated muscle Na+ channel genes are dispersed in the genome.

UR - http://www.scopus.com/inward/record.url?scp=0028908741&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028908741&partnerID=8YFLogxK

U2 - 10.1159/000133892

DO - 10.1159/000133892

M3 - Article

C2 - 7956363

AN - SCOPUS:0028908741

SN - 1424-8581

VL - 68

SP - 67

EP - 70

JO - Cytogenetic and Genome Research

JF - Cytogenetic and Genome Research

IS - 1-2

ER -

Assignment of the human heart tetrodotoxin-resistant voltage-gated Na⁺ channel α-subunit gene (SCN5A) to band 3p21

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this