TY - JOUR
T1 - Association between frailty and components of the frailty phenotype with modifiable risk factors and antiretroviral therapy
AU - Erlandson, Kristine M.
AU - Wu, Kunling
AU - Koletar, Susan L.
AU - Kalayjian, Robert C.
AU - Ellis, Ronald J.
AU - Taiwo, Babafemi
AU - Palella, Frank J.
AU - Tassiopoulos, Katherine
N1 - Publisher Copyright:
© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.
PY - 2017/3/15
Y1 - 2017/3/15
N2 - The impact of antiretroviral therapy (ART) on frailty among human immunodeficiency virus (HIV).infected adults has not been well described. HIV-infected participants aged.40 years with initial ART receipt through a randomized, controlled AIDS Clinical Trials Group trial completed a frailty assessment. Ordinal logistic regression models examined factors associated with frailty. Of 1016 participants, 6% were frail, and 38% were prefrail. Frailty was associated with lower education, older age, Medicare/Medicaid, initial efavirenz, smoking, obesity, and neurocognitive impairment; physical activity and alcohol use were protective. The associations with ART require further investigation, and associations between frailty and modifiable factors provide targets for future interventions.
AB - The impact of antiretroviral therapy (ART) on frailty among human immunodeficiency virus (HIV).infected adults has not been well described. HIV-infected participants aged.40 years with initial ART receipt through a randomized, controlled AIDS Clinical Trials Group trial completed a frailty assessment. Ordinal logistic regression models examined factors associated with frailty. Of 1016 participants, 6% were frail, and 38% were prefrail. Frailty was associated with lower education, older age, Medicare/Medicaid, initial efavirenz, smoking, obesity, and neurocognitive impairment; physical activity and alcohol use were protective. The associations with ART require further investigation, and associations between frailty and modifiable factors provide targets for future interventions.
KW - Antiretroviral therapy
KW - Frail elderly
KW - HIV
KW - Mobility limitation
KW - Muscle strength
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U2 - 10.1093/infdis/jix063
DO - 10.1093/infdis/jix063
M3 - Article
C2 - 28453849
AN - SCOPUS:85019706682
VL - 215
SP - 933
EP - 937
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 6
ER -
