Association between frailty and components of the frailty phenotype with modifiable risk factors and antiretroviral therapy

Kristine M. Erlandson; Kunling Wu; Susan L. Koletar; Robert C. Kalayjian; Ronald J. Ellis; Babafemi Taiwo; Frank J. Palella; Katherine Tassiopoulos

doi:10.1093/infdis/jix063

Association between frailty and components of the frailty phenotype with modifiable risk factors and antiretroviral therapy

Kristine M. Erlandson^*, Kunling Wu, Susan L. Koletar, Robert C. Kalayjian, Ronald J. Ellis, Babafemi Taiwo, Frank J. Palella, Katherine Tassiopoulos

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Article

24 Scopus citations

Abstract

The impact of antiretroviral therapy (ART) on frailty among human immunodeficiency virus (HIV).infected adults has not been well described. HIV-infected participants aged.40 years with initial ART receipt through a randomized, controlled AIDS Clinical Trials Group trial completed a frailty assessment. Ordinal logistic regression models examined factors associated with frailty. Of 1016 participants, 6% were frail, and 38% were prefrail. Frailty was associated with lower education, older age, Medicare/Medicaid, initial efavirenz, smoking, obesity, and neurocognitive impairment; physical activity and alcohol use were protective. The associations with ART require further investigation, and associations between frailty and modifiable factors provide targets for future interventions.

Original language	English (US)
Pages (from-to)	933-937
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	215
Issue number	6
DOIs	https://doi.org/10.1093/infdis/jix063
State	Published - Mar 15 2017

Keywords

Antiretroviral therapy
Frail elderly
HIV
Mobility limitation
Muscle strength

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

Access to Document

10.1093/infdis/jix063

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Erlandson, K. M., Wu, K., Koletar, S. L., Kalayjian, R. C., Ellis, R. J., Taiwo, B., Palella, F. J., & Tassiopoulos, K. (2017). Association between frailty and components of the frailty phenotype with modifiable risk factors and antiretroviral therapy. Journal of Infectious Diseases, 215(6), 933-937. https://doi.org/10.1093/infdis/jix063

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abstract = "The impact of antiretroviral therapy (ART) on frailty among human immunodeficiency virus (HIV).infected adults has not been well described. HIV-infected participants aged.40 years with initial ART receipt through a randomized, controlled AIDS Clinical Trials Group trial completed a frailty assessment. Ordinal logistic regression models examined factors associated with frailty. Of 1016 participants, 6% were frail, and 38% were prefrail. Frailty was associated with lower education, older age, Medicare/Medicaid, initial efavirenz, smoking, obesity, and neurocognitive impairment; physical activity and alcohol use were protective. The associations with ART require further investigation, and associations between frailty and modifiable factors provide targets for future interventions.",

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Association between frailty and components of the frailty phenotype with modifiable risk factors and antiretroviral therapy. / Erlandson, Kristine M.; Wu, Kunling; Koletar, Susan L.; Kalayjian, Robert C.; Ellis, Ronald J.; Taiwo, Babafemi ; Palella, Frank J.; Tassiopoulos, Katherine.

In: Journal of Infectious Diseases, Vol. 215, No. 6, 15.03.2017, p. 933-937.

Research output: Contribution to journal › Article

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