TY - JOUR
T1 - Association between IgE levels and asthma severity among African American, Mexican, and Puerto Rican patients with asthma
AU - Naqvi, Mariam
AU - Choudhry, Shweta
AU - Tsai, Hui Ju
AU - Thyne, Shannon
AU - Navarro, Daniel
AU - Nazario, Sylvette
AU - Rodriguez-Santana, Jose R.
AU - Casal, Jesus
AU - Torres, Alfonso
AU - Chapela, Rocio
AU - Watson, H. Geoffrey
AU - Meade, Kelley
AU - Rodriguez-Cintron, William
AU - LeNoir, Michael
AU - Avila, Pedro C.
AU - Burchard, Esteban González
PY - 2007/7
Y1 - 2007/7
N2 - Background: High levels of IgE are associated with asthma. Whether higher levels of IgE are associated with more severe asthma is still unclear. Objective: To determine whether IgE is associated with asthma severity among Latino and African American subjects with asthma. Methods: We assessed lung function and asthma severity among African American, Mexican, and Puerto Rican patients with asthma with high IgE levels (≥100 IU/mL; n = 492) and compared these values to those of patients with asthma with low IgE levels (<100 IU/mL; n = 247). We also examined IgE as a continuous variable among these groups. Results: Patients with asthma with high IgE had a lower mean FEV1 (87.6 ± 17.1, percent of predicted) than patients with asthma with low IgE (91.5 ± 17.0; P = .031). Regardless of race and ethnicity, baseline FEV1, forced expiratory flow, and FEV1/forced vital capacity were lower among subjects with high IgE than among subjects with low IgE (P = .031, P < .0001, P = .0001, respectively). In addition, 54.7% of patients with asthma with high IgE had been previously hospitalized, compared with 44.1% of patients with asthma with low IgE (odds ratio, 1.33; 95% CI, 1.04-1.71). Conclusion: Higher IgE is associated with lower baseline lung function and more severe asthma among these populations. Clinical implications: Among patients with asthma from 3 ethnically distinct groups, total IgE levels are inversely correlated with baseline lung function and asthma severity.
AB - Background: High levels of IgE are associated with asthma. Whether higher levels of IgE are associated with more severe asthma is still unclear. Objective: To determine whether IgE is associated with asthma severity among Latino and African American subjects with asthma. Methods: We assessed lung function and asthma severity among African American, Mexican, and Puerto Rican patients with asthma with high IgE levels (≥100 IU/mL; n = 492) and compared these values to those of patients with asthma with low IgE levels (<100 IU/mL; n = 247). We also examined IgE as a continuous variable among these groups. Results: Patients with asthma with high IgE had a lower mean FEV1 (87.6 ± 17.1, percent of predicted) than patients with asthma with low IgE (91.5 ± 17.0; P = .031). Regardless of race and ethnicity, baseline FEV1, forced expiratory flow, and FEV1/forced vital capacity were lower among subjects with high IgE than among subjects with low IgE (P = .031, P < .0001, P = .0001, respectively). In addition, 54.7% of patients with asthma with high IgE had been previously hospitalized, compared with 44.1% of patients with asthma with low IgE (odds ratio, 1.33; 95% CI, 1.04-1.71). Conclusion: Higher IgE is associated with lower baseline lung function and more severe asthma among these populations. Clinical implications: Among patients with asthma from 3 ethnically distinct groups, total IgE levels are inversely correlated with baseline lung function and asthma severity.
KW - African Americans
KW - Asthma
KW - IgE
KW - Mexicans
KW - Puerto Ricans
KW - allergy
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U2 - 10.1016/j.jaci.2007.02.045
DO - 10.1016/j.jaci.2007.02.045
M3 - Article
C2 - 17498790
AN - SCOPUS:34250853449
SN - 0091-6749
VL - 120
SP - 137
EP - 143
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 1
ER -