TY - JOUR
T1 - Association between indices of body mass and antibody titers to heat-shock protein-27 in healthy subjects
AU - Tavallaie, Shima
AU - Rahsepar, Amir Ali
AU - Abdi, Hamid
AU - Moohebati, Mohsen
AU - Moodi, Fatemeh
AU - Pourghadamyari, Hossein
AU - Esmaily, Habibollah
AU - Khorashadizadeh, Fatemeh
AU - Ghayour-Mobarhan, Majid
AU - Ferns, Gordon A.A.
PY - 2012/1
Y1 - 2012/1
N2 - Objectives: We have assessed the relationship between indices of adiposity and antibody titers to Hsp-27 in healthy subjects. Design: Two-hundred and fifty subjects were studied, including 50 normal-weight subjects (body-mass-index (BMI) [U+02C2]25kg/m 2), 100 overweight subjects (BMI 25 to [U+02C2]30kg/m 2) (n=100) and 100 obese subjects (BMI ≥30kg/m 2). Results: Anti-Hsp27-antibody levels in obese subjects were [0.34 (0.20-0.39) absorbency unit], being significantly higher than overweight and normal-weight groups (P< 0.05). Anti-Hsp27-antibody levels in overweight subjects [0.29 (0.15-0.34) absorbency unit] were statistically higher than controls [0.18 (0.10-0.23) absorbency unit] (P< 0.05). Conclusion: High anti-Hsp-27-antibody levels in obese-subjects without established coronary disease may be related to a heightened state of immunoactivation associated with obesity.
AB - Objectives: We have assessed the relationship between indices of adiposity and antibody titers to Hsp-27 in healthy subjects. Design: Two-hundred and fifty subjects were studied, including 50 normal-weight subjects (body-mass-index (BMI) [U+02C2]25kg/m 2), 100 overweight subjects (BMI 25 to [U+02C2]30kg/m 2) (n=100) and 100 obese subjects (BMI ≥30kg/m 2). Results: Anti-Hsp27-antibody levels in obese subjects were [0.34 (0.20-0.39) absorbency unit], being significantly higher than overweight and normal-weight groups (P< 0.05). Anti-Hsp27-antibody levels in overweight subjects [0.29 (0.15-0.34) absorbency unit] were statistically higher than controls [0.18 (0.10-0.23) absorbency unit] (P< 0.05). Conclusion: High anti-Hsp-27-antibody levels in obese-subjects without established coronary disease may be related to a heightened state of immunoactivation associated with obesity.
KW - Antibody
KW - Heat shock protein
KW - Obesity
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U2 - 10.1016/j.clinbiochem.2011.09.022
DO - 10.1016/j.clinbiochem.2011.09.022
M3 - Article
C2 - 22019951
AN - SCOPUS:84855330156
SN - 0009-9120
VL - 45
SP - 144
EP - 147
JO - Clinical Biochemistry
JF - Clinical Biochemistry
IS - 1-2
ER -
