TY - JOUR
T1 - Association between inflammatory bowel disease and prostate cancer
T2 - A large-scale, prospective, population-based study
AU - Meyers, Travis J.
AU - Weiner, Adam B.
AU - Graff, Rebecca E.
AU - Desai, Anuj S.
AU - Cooley, Lauren Folgosa
AU - Catalona, William J.
AU - Hanauer, Stephen B.
AU - Wu, Jennifer D.
AU - Schaeffer, Edward M.
AU - Abdulkadir, Sarki A.
AU - Kundu, Shilajit D.
AU - Witte, John S.
N1 - Funding Information:
This research has been conducted using the UK Biobank Resource under Application Number 14105. This research was funded by the following NIH grants: NCI R25CA112355, NCI R01CA201358 and NIA T32AG049663.
PY - 2020/11/15
Y1 - 2020/11/15
N2 - Inflammatory bowel disease (IBD) is an established risk factor for colorectal cancer. Recent reports suggesting IBD is also a risk factor for prostate cancer (PC) require further investigation. We studied 218 084 men in the population-based UK Biobank cohort, aged 40 to 69 at study entry between 2006 and 2010, with follow-up through mid-2015. We assessed the association between IBD and subsequent PC using multivariable Cox regression analyses, adjusting for age at assessment, ethnic group, UK region, smoking status, alcohol drinking frequency, body mass index, Townsend Deprivation Index, family history of PC and previous prostate-specific antigen testing. Mean age at study entry was 56 years, 94% of the men were white, and 1.1% (n = 2311) had a diagnosis of IBD. After a median follow-up of 78 months, men with IBD had an increased risk of PC (adjusted hazard ratio [aHR] = 1.31, 95% confidence interval [CI] = 1.03-1.67, P =.029). The association with PC was only among men with the ulcerative colitis (UC; aHR = 1.47, 95% CI = 1.11-1.95, P =.0070), and not Crohn's disease (aHR 1.06, 95% CI = 0.63-1.80, P =.82). Results are limited by lack of data on frequency of health care interactions. In a large-scale, prospective cohort study, we detected an association between IBD, and UC specifically, with incident PC diagnosis.
AB - Inflammatory bowel disease (IBD) is an established risk factor for colorectal cancer. Recent reports suggesting IBD is also a risk factor for prostate cancer (PC) require further investigation. We studied 218 084 men in the population-based UK Biobank cohort, aged 40 to 69 at study entry between 2006 and 2010, with follow-up through mid-2015. We assessed the association between IBD and subsequent PC using multivariable Cox regression analyses, adjusting for age at assessment, ethnic group, UK region, smoking status, alcohol drinking frequency, body mass index, Townsend Deprivation Index, family history of PC and previous prostate-specific antigen testing. Mean age at study entry was 56 years, 94% of the men were white, and 1.1% (n = 2311) had a diagnosis of IBD. After a median follow-up of 78 months, men with IBD had an increased risk of PC (adjusted hazard ratio [aHR] = 1.31, 95% confidence interval [CI] = 1.03-1.67, P =.029). The association with PC was only among men with the ulcerative colitis (UC; aHR = 1.47, 95% CI = 1.11-1.95, P =.0070), and not Crohn's disease (aHR 1.06, 95% CI = 0.63-1.80, P =.82). Results are limited by lack of data on frequency of health care interactions. In a large-scale, prospective cohort study, we detected an association between IBD, and UC specifically, with incident PC diagnosis.
KW - cohort study
KW - inflammatory bowel disease
KW - prostate cancer
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U2 - 10.1002/ijc.33048
DO - 10.1002/ijc.33048
M3 - Article
C2 - 32399975
AN - SCOPUS:85085475773
VL - 147
SP - 2735
EP - 2742
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 10
ER -