Association between leaflet fusion pattern and thoracic aorta morphology in patients with bicuspid aortic valve

Bryce A. Merritt*, Alexander Turin, Michael Markl, S Chris Malaisrie, Patrick M McCarthy, James Carr

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Purpose To determine if patients with certain bicuspid aortic valve (BAV) phenotypes are predisposed to particular morphological abnormalities of the thoracic aorta. Materials and Methods One hundred ninety-two patients with BAV who underwent magnetic resonance angiography between January 2007 and July 2010 were retrospectively identified. Aortic morphology was examined through measurements of aortic size index at nine levels along the thoracic aorta, three-dimensional volume of the ascending aorta, vessel asymmetry, and assessment of aortic root morphology. Results We found 140 patients (73%) with right and left coronary cusps (R-L) fusion, 46 patients (24%) with R-N fusion, and 6 patients (3%) with left and noncoronary cusps (L-N) fusion. Mean aortic volume in the proximal ascending aorta was significantly greater in R-L patients (0.93 versus 0.60 cm3/m2; P < 0.01). R-N patients possessed greater aortic size index at the distal ascending aorta and proximal aortic arch, and were also significantly more likely to have Type 2 patterns of aortic dilatation. Conclusion Our results suggest that BAV with R-L fusion is associated with increased dimensions of the aortic root, while BAV with R-N fusion is associated with increased dimensions of the distal ascending aorta and proximal arch. Our findings illustrate the morphological heterogeneity that exists among BAV phenotypes.

Original languageEnglish (US)
Pages (from-to)294-300
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume40
Issue number2
DOIs
StatePublished - Jan 1 2014

Keywords

  • BAV
  • CMR
  • thoracic aorta

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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