Association Between Long-Term Lipid Profiles and Disease Severity in a Large Cohort of Patients with Inflammatory Bowel Disease

Efstratios Koutroumpakis, Claudia Ramos-Rivers, Miguel Regueiro, Jana G. Hashash, Arthur Barrie, Jason Swoger, Leonard Baidoo, Marc Schwartz, Michael A. Dunn, Ioannis E. Koutroubakis, David G. Binion*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Background: Inflammatory bowel disease (IBD) has been linked to an increased risk of coronary heart disease and stroke. Dyslipidemia is a well-established risk factor for cardiovascular disease. The aim of this study was to investigate the long-term lipid profiles in a large cohort of IBD patients. Methods: Data of patients from an IBD registry who had more than one measurement of total cholesterol and triglyceride levels during the follow-up period were analyzed. The lipid profiles of IBD patients were compared to those of the general population according to National Health and Nutrition Examination Survey (2009–2012). Quartiles of cholesterol or triglyceride levels in relation to surrogate markers of disease severity were analyzed. Results: Seven hundred and one IBD patients [54 % Crohn’s disease (CD), 46 % ulcerative colitis (UC)] were included. IBD patients had less frequent high total cholesterol and high LDL cholesterol (6 vs. 13 and 5 vs. 10 %) and more frequent low HDL and high triglycerides (24 vs. 17 and 33 vs. 25 %) compared to the general population (all p < 0.001). Median total cholesterol levels were lower and median triglycerides higher in CD compared to UC (171 vs. 184; 123 vs. 100 mg/dL; both p < 0.001). In the multiple regression analysis, lipid profile was independently associated with hospitalizations (low cholesterol) and IBD surgeries (low cholesterol and high triglycerides). Conclusions: Low total cholesterol and high triglyceride levels are more frequent in IBD patients (in particular CD) compared to healthy controls and are independently associated with more severe disease.

Original languageEnglish (US)
Pages (from-to)865-871
Number of pages7
JournalDigestive diseases and sciences
Issue number3
StatePublished - Mar 1 2016


  • Cardiovascular risk
  • Cholesterol
  • Crohn’s disease
  • Triglycerides
  • Ulcerative colitis

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology


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