Association between severity of asthma and degree of chronic rhinosinusitis

David C. Lin, Rakesh K. Chandra*, Bruce K. Tan, Whitney Zirkle, David B. Conley, Leslie C. Grammer, Robert C. Kern, Robert P. Schleimer, Anju T. Peters

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

161 Scopus citations


Background: There is a clinical association between asthma and chronic rhinosinusitis (CRS). This study was designed to determine whether severity of coexistent asthma affects the clinical presentation of CRS. Methods: Cross-sectional analysis was performed of prospectively collected data in 187 patients with CRS who were evaluated in a large, tertiary academic nasal and sinus center. Patients were stratified into three groups based on asthma status using National Institutes of Health criteria: (1) nonasthmatic, (2) intermittent/mild asthma, (3) or moderate/severe asthma. Results: Mean Lund-Mackay scores were 9.7, 11.6, and 15.6, respectively. ANOVA testing with post-hoc Tukey analysis revealed that Lund-MacKay scores were significantly greater in group 3 than either group 1 (p < 0.05) or group 2 (p < 0.01). The prevalence of allergic sensitization was 72.4, 82.8, and 100% in groups 1, 2, and 3, respectively (p = 0.03). The prevalence of nasal polyposis was 31.4% in group 1, 48.3% in group 2, and 94.4% in group 3 (p < 0.0001). No differences were observed regarding demographic factors or the incidence of the triad of aspirin sensitivity, asthma, and nasal polyposis among those with different severities of asthma. Conclusion: Increasing severity of asthma is associated with advancing radiological severity of CRS and a greater prevalence of allergic sensitization and nasal polyposis. This large adult series shows that asthma severity may have a significant correlation with the presentation of CRS. This study adds to the growing support for the unified airway theory.

Original languageEnglish (US)
Pages (from-to)205-208
Number of pages4
JournalAmerican Journal of Rhinology and Allergy
Issue number4
StatePublished - Jul 2011

ASJC Scopus subject areas

  • Immunology and Allergy
  • Otorhinolaryngology


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