TY - JOUR
T1 - Association between sleep quality and C-reactive protein
T2 - Results from national health and nutrition examination survey, 2005-2008
AU - Liu, Rong
AU - Liu, Xin
AU - Zee, Phyllis C.
AU - Hou, Lifang
AU - Zheng, Zheng
AU - Wei, Yongxiang
AU - Du, Jie
PY - 2014/3/24
Y1 - 2014/3/24
N2 - Objective: Our objective was to explore the association between poor sleep quality and hs-CRP in an adult U.S. population. Methods: This study focused on 9,317 participants in the National Health and Nutrition Examination Survey (NHANES) from 2005-2008 who were aged 20-85 years, completed a sleep disorder questionnaire, and had available information on serum hs-CRP. Sleep quality was classified into three categories (good, moderate, poor) based on the responses of participants to the NHANES sleep disorder questionnaire. High CRP was defined as hs-CRP >1 md/dL. Linear regression model was applied to investigate the association between poor sleep quality and log-transformed hs-CRP. And logistic regression model was fitted to evaluate the association between sleep quality and the risk of high CRP. Results: Females were more likely to report poor sleep quality than males (26% vs. 19%, p<0.0001). Each sleep disorder was significantly associated with increased hs-CRP and correlative to other sleep disorders. In fully-adjusted linear regression model, poor sleep quality was significantly associated with elevated hs-CRP (log transformed) among the overall sample and in females only (β = 0.10, se = 0.03, p<0.01 and β = 0.13, se = 0.04, p<0.01, respectively). In fully-adjusted logistics regression model, poor sleep quality was linked with risk of high CRP(OR: 1.42, 95%CI: 1.15-1.76 in overall sample and OR: 1.59, 95%CI: 1.18-2.14 in females, respectively). Conclusion: We found that poor sleep quality was independently associated with elevated hs-CRP in females but not in males in a U.S. adult population.
AB - Objective: Our objective was to explore the association between poor sleep quality and hs-CRP in an adult U.S. population. Methods: This study focused on 9,317 participants in the National Health and Nutrition Examination Survey (NHANES) from 2005-2008 who were aged 20-85 years, completed a sleep disorder questionnaire, and had available information on serum hs-CRP. Sleep quality was classified into three categories (good, moderate, poor) based on the responses of participants to the NHANES sleep disorder questionnaire. High CRP was defined as hs-CRP >1 md/dL. Linear regression model was applied to investigate the association between poor sleep quality and log-transformed hs-CRP. And logistic regression model was fitted to evaluate the association between sleep quality and the risk of high CRP. Results: Females were more likely to report poor sleep quality than males (26% vs. 19%, p<0.0001). Each sleep disorder was significantly associated with increased hs-CRP and correlative to other sleep disorders. In fully-adjusted linear regression model, poor sleep quality was significantly associated with elevated hs-CRP (log transformed) among the overall sample and in females only (β = 0.10, se = 0.03, p<0.01 and β = 0.13, se = 0.04, p<0.01, respectively). In fully-adjusted logistics regression model, poor sleep quality was linked with risk of high CRP(OR: 1.42, 95%CI: 1.15-1.76 in overall sample and OR: 1.59, 95%CI: 1.18-2.14 in females, respectively). Conclusion: We found that poor sleep quality was independently associated with elevated hs-CRP in females but not in males in a U.S. adult population.
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U2 - 10.1371/journal.pone.0092607
DO - 10.1371/journal.pone.0092607
M3 - Article
C2 - 24663098
AN - SCOPUS:84899766203
SN - 1932-6203
VL - 9
JO - PLoS One
JF - PLoS One
IS - 3
M1 - e92607
ER -