Association between traumatic brain injury-related brain lesions and long-term caregiver burden

Andrea Brioschi Guevara, Jean Francois Demonet, Elena Polejaeva, Kristine M. Knutson, Eric M. Wassermann, Jordan Henry Grafman, Frank Krueger*

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: To investigate the association between traumatic brain injury (TBI)-related brain lesions and long-term caregiver burden in relation to dysexecutive syndrome. Setting: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland. Participants: A total of 256 participants: 105 combat veterans with TBI, 23 healthy control combat veterans (HCv), and 128 caregivers. Outcome Measure: Caregiver burden assessed by the Zarit Burden Interview at 40 years postinjury. Design: Participants with penetrating TBI were compared with HCv on perceived caregiver burden and neuropsychological assessment measures. Data of computed tomographic scans (overlay lesion maps of participants with a penetrating TBI whose caregivers have a significantly high burden) and behavioral statistical analyses were combined to identify brain lesions associated with caregiver burden. Results: Burden was greater in caregivers of veterans with TBI than in caregivers of HCv. Caregivers of participants with lesions affecting cognitive and behavioral indicators of dysexecutive syndrome (ie, left dorsolateral prefrontal cortex and dorsal anterior cingulate cortex) showed greater long-term burden than caregivers of participants with lesions elsewhere in the brain. Conclusion and Implication: The TBI-related brain lesions have a lasting effect on long-term caregiver burden due to cognitive and behavioral factors associated with dysexecutive syndrome.

Original languageEnglish (US)
Pages (from-to)E48-E58
JournalJournal of Head Trauma Rehabilitation
Volume31
Issue number2
DOIs
StatePublished - Mar 4 2016

Fingerprint

Caregivers
Brain
Veterans
Penetrating Head Injuries
Traumatic Brain Injury
National Institute of Neurological Disorders and Stroke
Gyrus Cinguli
National Institutes of Health (U.S.)
Prefrontal Cortex
Outcome Assessment (Health Care)
Interviews

Keywords

  • Caregiver burden
  • Dorsal anterior cingulate cortex (dACC)
  • Dorsolateral prefrontal cortex (dlPFC)
  • Dysexecutive syndrome
  • Executive functions (EFs)
  • Traumatic brain injury (TBI)

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation
  • Clinical Neurology

Cite this

Guevara, Andrea Brioschi ; Demonet, Jean Francois ; Polejaeva, Elena ; Knutson, Kristine M. ; Wassermann, Eric M. ; Grafman, Jordan Henry ; Krueger, Frank. / Association between traumatic brain injury-related brain lesions and long-term caregiver burden. In: Journal of Head Trauma Rehabilitation. 2016 ; Vol. 31, No. 2. pp. E48-E58.
@article{02db20829cda44649f8496d22898526b,
title = "Association between traumatic brain injury-related brain lesions and long-term caregiver burden",
abstract = "Objective: To investigate the association between traumatic brain injury (TBI)-related brain lesions and long-term caregiver burden in relation to dysexecutive syndrome. Setting: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland. Participants: A total of 256 participants: 105 combat veterans with TBI, 23 healthy control combat veterans (HCv), and 128 caregivers. Outcome Measure: Caregiver burden assessed by the Zarit Burden Interview at 40 years postinjury. Design: Participants with penetrating TBI were compared with HCv on perceived caregiver burden and neuropsychological assessment measures. Data of computed tomographic scans (overlay lesion maps of participants with a penetrating TBI whose caregivers have a significantly high burden) and behavioral statistical analyses were combined to identify brain lesions associated with caregiver burden. Results: Burden was greater in caregivers of veterans with TBI than in caregivers of HCv. Caregivers of participants with lesions affecting cognitive and behavioral indicators of dysexecutive syndrome (ie, left dorsolateral prefrontal cortex and dorsal anterior cingulate cortex) showed greater long-term burden than caregivers of participants with lesions elsewhere in the brain. Conclusion and Implication: The TBI-related brain lesions have a lasting effect on long-term caregiver burden due to cognitive and behavioral factors associated with dysexecutive syndrome.",
keywords = "Caregiver burden, Dorsal anterior cingulate cortex (dACC), Dorsolateral prefrontal cortex (dlPFC), Dysexecutive syndrome, Executive functions (EFs), Traumatic brain injury (TBI)",
author = "Guevara, {Andrea Brioschi} and Demonet, {Jean Francois} and Elena Polejaeva and Knutson, {Kristine M.} and Wassermann, {Eric M.} and Grafman, {Jordan Henry} and Frank Krueger",
year = "2016",
month = "3",
day = "4",
doi = "10.1097/HTR.0000000000000151",
language = "English (US)",
volume = "31",
pages = "E48--E58",
journal = "Journal of Head Trauma Rehabilitation",
issn = "0885-9701",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

Association between traumatic brain injury-related brain lesions and long-term caregiver burden. / Guevara, Andrea Brioschi; Demonet, Jean Francois; Polejaeva, Elena; Knutson, Kristine M.; Wassermann, Eric M.; Grafman, Jordan Henry; Krueger, Frank.

In: Journal of Head Trauma Rehabilitation, Vol. 31, No. 2, 04.03.2016, p. E48-E58.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between traumatic brain injury-related brain lesions and long-term caregiver burden

AU - Guevara, Andrea Brioschi

AU - Demonet, Jean Francois

AU - Polejaeva, Elena

AU - Knutson, Kristine M.

AU - Wassermann, Eric M.

AU - Grafman, Jordan Henry

AU - Krueger, Frank

PY - 2016/3/4

Y1 - 2016/3/4

N2 - Objective: To investigate the association between traumatic brain injury (TBI)-related brain lesions and long-term caregiver burden in relation to dysexecutive syndrome. Setting: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland. Participants: A total of 256 participants: 105 combat veterans with TBI, 23 healthy control combat veterans (HCv), and 128 caregivers. Outcome Measure: Caregiver burden assessed by the Zarit Burden Interview at 40 years postinjury. Design: Participants with penetrating TBI were compared with HCv on perceived caregiver burden and neuropsychological assessment measures. Data of computed tomographic scans (overlay lesion maps of participants with a penetrating TBI whose caregivers have a significantly high burden) and behavioral statistical analyses were combined to identify brain lesions associated with caregiver burden. Results: Burden was greater in caregivers of veterans with TBI than in caregivers of HCv. Caregivers of participants with lesions affecting cognitive and behavioral indicators of dysexecutive syndrome (ie, left dorsolateral prefrontal cortex and dorsal anterior cingulate cortex) showed greater long-term burden than caregivers of participants with lesions elsewhere in the brain. Conclusion and Implication: The TBI-related brain lesions have a lasting effect on long-term caregiver burden due to cognitive and behavioral factors associated with dysexecutive syndrome.

AB - Objective: To investigate the association between traumatic brain injury (TBI)-related brain lesions and long-term caregiver burden in relation to dysexecutive syndrome. Setting: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland. Participants: A total of 256 participants: 105 combat veterans with TBI, 23 healthy control combat veterans (HCv), and 128 caregivers. Outcome Measure: Caregiver burden assessed by the Zarit Burden Interview at 40 years postinjury. Design: Participants with penetrating TBI were compared with HCv on perceived caregiver burden and neuropsychological assessment measures. Data of computed tomographic scans (overlay lesion maps of participants with a penetrating TBI whose caregivers have a significantly high burden) and behavioral statistical analyses were combined to identify brain lesions associated with caregiver burden. Results: Burden was greater in caregivers of veterans with TBI than in caregivers of HCv. Caregivers of participants with lesions affecting cognitive and behavioral indicators of dysexecutive syndrome (ie, left dorsolateral prefrontal cortex and dorsal anterior cingulate cortex) showed greater long-term burden than caregivers of participants with lesions elsewhere in the brain. Conclusion and Implication: The TBI-related brain lesions have a lasting effect on long-term caregiver burden due to cognitive and behavioral factors associated with dysexecutive syndrome.

KW - Caregiver burden

KW - Dorsal anterior cingulate cortex (dACC)

KW - Dorsolateral prefrontal cortex (dlPFC)

KW - Dysexecutive syndrome

KW - Executive functions (EFs)

KW - Traumatic brain injury (TBI)

UR - http://www.scopus.com/inward/record.url?scp=84962612201&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962612201&partnerID=8YFLogxK

U2 - 10.1097/HTR.0000000000000151

DO - 10.1097/HTR.0000000000000151

M3 - Article

VL - 31

SP - E48-E58

JO - Journal of Head Trauma Rehabilitation

JF - Journal of Head Trauma Rehabilitation

SN - 0885-9701

IS - 2

ER -