Abstract
Objective: To investigate the association between traumatic brain injury (TBI)-related brain lesions and long-term caregiver burden in relation to dysexecutive syndrome. Setting: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland. Participants: A total of 256 participants: 105 combat veterans with TBI, 23 healthy control combat veterans (HCv), and 128 caregivers. Outcome Measure: Caregiver burden assessed by the Zarit Burden Interview at 40 years postinjury. Design: Participants with penetrating TBI were compared with HCv on perceived caregiver burden and neuropsychological assessment measures. Data of computed tomographic scans (overlay lesion maps of participants with a penetrating TBI whose caregivers have a significantly high burden) and behavioral statistical analyses were combined to identify brain lesions associated with caregiver burden. Results: Burden was greater in caregivers of veterans with TBI than in caregivers of HCv. Caregivers of participants with lesions affecting cognitive and behavioral indicators of dysexecutive syndrome (ie, left dorsolateral prefrontal cortex and dorsal anterior cingulate cortex) showed greater long-term burden than caregivers of participants with lesions elsewhere in the brain. Conclusion and Implication: The TBI-related brain lesions have a lasting effect on long-term caregiver burden due to cognitive and behavioral factors associated with dysexecutive syndrome.
| Original language | English (US) |
|---|---|
| Pages (from-to) | E48-E58 |
| Journal | Journal of Head Trauma Rehabilitation |
| Volume | 31 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 4 2016 |
Fingerprint
Keywords
- Caregiver burden
- Dorsal anterior cingulate cortex (dACC)
- Dorsolateral prefrontal cortex (dlPFC)
- Dysexecutive syndrome
- Executive functions (EFs)
- Traumatic brain injury (TBI)
ASJC Scopus subject areas
- Physical Therapy, Sports Therapy and Rehabilitation
- Rehabilitation
- Clinical Neurology
Cite this
}
Association between traumatic brain injury-related brain lesions and long-term caregiver burden. / Guevara, Andrea Brioschi; Demonet, Jean Francois; Polejaeva, Elena; Knutson, Kristine M.; Wassermann, Eric M.; Grafman, Jordan Henry; Krueger, Frank.
In: Journal of Head Trauma Rehabilitation, Vol. 31, No. 2, 04.03.2016, p. E48-E58.Research output: Contribution to journal › Article
TY - JOUR
T1 - Association between traumatic brain injury-related brain lesions and long-term caregiver burden
AU - Guevara, Andrea Brioschi
AU - Demonet, Jean Francois
AU - Polejaeva, Elena
AU - Knutson, Kristine M.
AU - Wassermann, Eric M.
AU - Grafman, Jordan Henry
AU - Krueger, Frank
PY - 2016/3/4
Y1 - 2016/3/4
N2 - Objective: To investigate the association between traumatic brain injury (TBI)-related brain lesions and long-term caregiver burden in relation to dysexecutive syndrome. Setting: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland. Participants: A total of 256 participants: 105 combat veterans with TBI, 23 healthy control combat veterans (HCv), and 128 caregivers. Outcome Measure: Caregiver burden assessed by the Zarit Burden Interview at 40 years postinjury. Design: Participants with penetrating TBI were compared with HCv on perceived caregiver burden and neuropsychological assessment measures. Data of computed tomographic scans (overlay lesion maps of participants with a penetrating TBI whose caregivers have a significantly high burden) and behavioral statistical analyses were combined to identify brain lesions associated with caregiver burden. Results: Burden was greater in caregivers of veterans with TBI than in caregivers of HCv. Caregivers of participants with lesions affecting cognitive and behavioral indicators of dysexecutive syndrome (ie, left dorsolateral prefrontal cortex and dorsal anterior cingulate cortex) showed greater long-term burden than caregivers of participants with lesions elsewhere in the brain. Conclusion and Implication: The TBI-related brain lesions have a lasting effect on long-term caregiver burden due to cognitive and behavioral factors associated with dysexecutive syndrome.
AB - Objective: To investigate the association between traumatic brain injury (TBI)-related brain lesions and long-term caregiver burden in relation to dysexecutive syndrome. Setting: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland. Participants: A total of 256 participants: 105 combat veterans with TBI, 23 healthy control combat veterans (HCv), and 128 caregivers. Outcome Measure: Caregiver burden assessed by the Zarit Burden Interview at 40 years postinjury. Design: Participants with penetrating TBI were compared with HCv on perceived caregiver burden and neuropsychological assessment measures. Data of computed tomographic scans (overlay lesion maps of participants with a penetrating TBI whose caregivers have a significantly high burden) and behavioral statistical analyses were combined to identify brain lesions associated with caregiver burden. Results: Burden was greater in caregivers of veterans with TBI than in caregivers of HCv. Caregivers of participants with lesions affecting cognitive and behavioral indicators of dysexecutive syndrome (ie, left dorsolateral prefrontal cortex and dorsal anterior cingulate cortex) showed greater long-term burden than caregivers of participants with lesions elsewhere in the brain. Conclusion and Implication: The TBI-related brain lesions have a lasting effect on long-term caregiver burden due to cognitive and behavioral factors associated with dysexecutive syndrome.
KW - Caregiver burden
KW - Dorsal anterior cingulate cortex (dACC)
KW - Dorsolateral prefrontal cortex (dlPFC)
KW - Dysexecutive syndrome
KW - Executive functions (EFs)
KW - Traumatic brain injury (TBI)
UR - http://www.scopus.com/inward/record.url?scp=84962612201&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962612201&partnerID=8YFLogxK
U2 - 10.1097/HTR.0000000000000151
DO - 10.1097/HTR.0000000000000151
M3 - Article
VL - 31
SP - E48-E58
JO - Journal of Head Trauma Rehabilitation
JF - Journal of Head Trauma Rehabilitation
SN - 0885-9701
IS - 2
ER -