Association between traumatic brain injury-related brain lesions and long-term caregiver burden

Andrea Brioschi Guevara, Jean Francois Demonet, Elena Polejaeva, Kristine M. Knutson, Eric M. Wassermann, Jordan Grafman, Frank Krueger*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Objective: To investigate the association between traumatic brain injury (TBI)-related brain lesions and long-term caregiver burden in relation to dysexecutive syndrome. Setting: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland. Participants: A total of 256 participants: 105 combat veterans with TBI, 23 healthy control combat veterans (HCv), and 128 caregivers. Outcome Measure: Caregiver burden assessed by the Zarit Burden Interview at 40 years postinjury. Design: Participants with penetrating TBI were compared with HCv on perceived caregiver burden and neuropsychological assessment measures. Data of computed tomographic scans (overlay lesion maps of participants with a penetrating TBI whose caregivers have a significantly high burden) and behavioral statistical analyses were combined to identify brain lesions associated with caregiver burden. Results: Burden was greater in caregivers of veterans with TBI than in caregivers of HCv. Caregivers of participants with lesions affecting cognitive and behavioral indicators of dysexecutive syndrome (ie, left dorsolateral prefrontal cortex and dorsal anterior cingulate cortex) showed greater long-term burden than caregivers of participants with lesions elsewhere in the brain. Conclusion and Implication: The TBI-related brain lesions have a lasting effect on long-term caregiver burden due to cognitive and behavioral factors associated with dysexecutive syndrome.

Original languageEnglish (US)
Pages (from-to)E48-E58
JournalJournal of Head Trauma Rehabilitation
Issue number2
StatePublished - Mar 4 2016


  • Caregiver burden
  • Dorsal anterior cingulate cortex (dACC)
  • Dorsolateral prefrontal cortex (dlPFC)
  • Dysexecutive syndrome
  • Executive functions (EFs)
  • Traumatic brain injury (TBI)

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation
  • Clinical Neurology


Dive into the research topics of 'Association between traumatic brain injury-related brain lesions and long-term caregiver burden'. Together they form a unique fingerprint.

Cite this