Association between uterine fibroids and antimüllerian hormone concentrations among African American women

Lia A. Bernardi, Anne Waldo, Veronica J. Berrocal, Lauren A. Wise, Erica E. Marsh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective: To evaluate the extent to which uterine fibroids are associated with antimüllerian hormone (AMH) concentrations. Design: Cross-sectional study. Setting: Baseline data from the Study of the Environment, Lifestyle, and Fibroids, which is a 5-year longitudinal study of African American women. Patient(s): A total of 1,643 women aged 23–35 years without a known history of fibroids. Exposure: Fibroid presence. Intervention(s): None. Main Outcome Measure(s): The primary outcome was percent difference in the mean AMH concentration between participants with fibroids and those without fibroids. The secondary outcomes were percent differences in the mean AMH concentrations in participants with different numbers, sizes, types, and positions of fibroids and the percent difference in the mean AMH concentration in participants with different uterine volumes. Result(s): At least 1 fibroid was identified on ultrasound in 362 (22%) participants. There was a small difference in the mean AMH concentrations in participants with fibroids (age-adjusted model: −4.6%, 95% confidence interval (CI): −14.5% to 6.5%; multivariable model: −4.6%, 95% CI: −14.4% to 6.3%). The mean AMH concentrations were found to decrease with increasing fibroid number. Although differences in AMH concentrations were not statistically significant, compared with no fibroids, the mean percent differences in AMH concentrations for 1, 2–3, and ≥4 fibroids were −1.2% (95% CI: −13.2% to 12.5%), −7.1% (95% CI: −23.3% to 12.5%), and −17.5% (95% CI: −38.2% to 10.0%), respectively. There were no consistent associations between AMH concentrations and fibroid location, size, or uterine volume. Conclusion(s): The presence of fibroids was not materially associated with AMH concentrations. Other than a monotonic inverse relationship between fibroid number and AMH concentrations, no other fibroid characteristics were consistently or appreciably associated, although associations were imprecise.

Original languageEnglish (US)
Pages (from-to)832-840
Number of pages9
JournalFertility and Sterility
Volume117
Issue number4
DOIs
StatePublished - Apr 2022

Keywords

  • Antimüllerian hormone
  • ovarian reserve
  • uterine fibroids
  • uterine leiomyomas

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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