TY - JOUR
T1 - Association between uterine fibroids and antimüllerian hormone concentrations among African American women
AU - Bernardi, Lia A.
AU - Waldo, Anne
AU - Berrocal, Veronica J.
AU - Wise, Lauren A.
AU - Marsh, Erica E.
N1 - Funding Information:
Supported by the National Institutes of Health ( R01HD088638 ) (to E.E.M.).
Funding Information:
We thank Patrick Sluss, Ph.D. at Ansh Labs. We also thank the SELF participants and staff. The fibroid and covariate data for this analysis was provided by Donna Baird, Ph.D. and Quaker Harmon, M.D., Ph.D. Principal Investigator and Staff Scientist for SELF. SELF was funded by the Intramural Research Program of the National Institutes of Health, National Institute of Environmental Health Sciences (ZIAES049013) and, in part, by funds allocated for health research by the American Recovery and Reinvestment Act.
Publisher Copyright:
© 2021 American Society for Reproductive Medicine
PY - 2022/4
Y1 - 2022/4
N2 - Objective: To evaluate the extent to which uterine fibroids are associated with antimüllerian hormone (AMH) concentrations. Design: Cross-sectional study. Setting: Baseline data from the Study of the Environment, Lifestyle, and Fibroids, which is a 5-year longitudinal study of African American women. Patient(s): A total of 1,643 women aged 23–35 years without a known history of fibroids. Exposure: Fibroid presence. Intervention(s): None. Main Outcome Measure(s): The primary outcome was percent difference in the mean AMH concentration between participants with fibroids and those without fibroids. The secondary outcomes were percent differences in the mean AMH concentrations in participants with different numbers, sizes, types, and positions of fibroids and the percent difference in the mean AMH concentration in participants with different uterine volumes. Result(s): At least 1 fibroid was identified on ultrasound in 362 (22%) participants. There was a small difference in the mean AMH concentrations in participants with fibroids (age-adjusted model: −4.6%, 95% confidence interval (CI): −14.5% to 6.5%; multivariable model: −4.6%, 95% CI: −14.4% to 6.3%). The mean AMH concentrations were found to decrease with increasing fibroid number. Although differences in AMH concentrations were not statistically significant, compared with no fibroids, the mean percent differences in AMH concentrations for 1, 2–3, and ≥4 fibroids were −1.2% (95% CI: −13.2% to 12.5%), −7.1% (95% CI: −23.3% to 12.5%), and −17.5% (95% CI: −38.2% to 10.0%), respectively. There were no consistent associations between AMH concentrations and fibroid location, size, or uterine volume. Conclusion(s): The presence of fibroids was not materially associated with AMH concentrations. Other than a monotonic inverse relationship between fibroid number and AMH concentrations, no other fibroid characteristics were consistently or appreciably associated, although associations were imprecise.
AB - Objective: To evaluate the extent to which uterine fibroids are associated with antimüllerian hormone (AMH) concentrations. Design: Cross-sectional study. Setting: Baseline data from the Study of the Environment, Lifestyle, and Fibroids, which is a 5-year longitudinal study of African American women. Patient(s): A total of 1,643 women aged 23–35 years without a known history of fibroids. Exposure: Fibroid presence. Intervention(s): None. Main Outcome Measure(s): The primary outcome was percent difference in the mean AMH concentration between participants with fibroids and those without fibroids. The secondary outcomes were percent differences in the mean AMH concentrations in participants with different numbers, sizes, types, and positions of fibroids and the percent difference in the mean AMH concentration in participants with different uterine volumes. Result(s): At least 1 fibroid was identified on ultrasound in 362 (22%) participants. There was a small difference in the mean AMH concentrations in participants with fibroids (age-adjusted model: −4.6%, 95% confidence interval (CI): −14.5% to 6.5%; multivariable model: −4.6%, 95% CI: −14.4% to 6.3%). The mean AMH concentrations were found to decrease with increasing fibroid number. Although differences in AMH concentrations were not statistically significant, compared with no fibroids, the mean percent differences in AMH concentrations for 1, 2–3, and ≥4 fibroids were −1.2% (95% CI: −13.2% to 12.5%), −7.1% (95% CI: −23.3% to 12.5%), and −17.5% (95% CI: −38.2% to 10.0%), respectively. There were no consistent associations between AMH concentrations and fibroid location, size, or uterine volume. Conclusion(s): The presence of fibroids was not materially associated with AMH concentrations. Other than a monotonic inverse relationship between fibroid number and AMH concentrations, no other fibroid characteristics were consistently or appreciably associated, although associations were imprecise.
KW - Antimüllerian hormone
KW - ovarian reserve
KW - uterine fibroids
KW - uterine leiomyomas
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U2 - 10.1016/j.fertnstert.2021.12.019
DO - 10.1016/j.fertnstert.2021.12.019
M3 - Article
C2 - 35105447
AN - SCOPUS:85123703160
SN - 0015-0282
VL - 117
SP - 832
EP - 840
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 4
ER -