Association of Accelerometer-Measured Physical Activity with Leukocyte Telomere Length among Older Women

Aladdin H. Shadyab*, Michael J. Lamonte, Charles Kooperberg, Alexander P. Reiner, Cara L. Carty, Todd M. Manini, Lifang Hou, Chongzhi Di, Andrea Z. Lacroix

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background Previous studies on physical activity and telomere length have relied largely upon self-reported physical activity data, and few studies have examined older adults. The association of objectively measured physical activity with leukocyte telomere length (LTL) is currently unknown. Methods In this study, we examined cross-sectional associations between accelerometer-measured total, light, and moderate-to-vigorous physical activity (MVPA) and LTL, measured using Southern blot. The sample included 1,405 older (64-95 years old) white and African American women from the Women's Health Initiative. Multiple linear regression models adjusting for potential confounders were used to determine the association between accelerometer-measured physical activity and LTL. Results Overall, the mean (standard deviation) of total, light, and moderate-to-vigorous activity was 5.5 (1.6), 4.7 (1.3), and 0.8 (0.5) h/d, respectively. Adjusting for accelerometer wear time, age, race/ethnicity, education, marital status, smoking, alcohol, body mass index, a history of chronic diseases, and hormone therapy use, LTL was 80 (95% confidence interval: 9, 150) base pairs longer among women with ≥2.5 compared with <2.5 h/wk of MVPA. Light activity was not significantly associated with LTL. For total activity, the most physically active women had significantly longer LTL than the least active women after adjustment for demographic and lifestyle characteristics; however, findings were not significant after further adjustment for health-related factors. Conclusions Older women meeting current recommendations of ≥2.5 h/wk of MVPA, as assessed by accelerometer, had longer LTL. Additional studies using accelerometers in large, diverse cohorts of older women are needed to confirm and extend these findings.

Original languageEnglish (US)
Pages (from-to)1532-1537
Number of pages6
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume72
Issue number11
DOIs
StatePublished - Nov 1 2017

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Telomere
Leukocytes
Exercise
Light
Linear Models
Marital Status
Women's Health
Southern Blotting
Base Pairing
African Americans
Life Style
Body Mass Index
Chronic Disease
Cross-Sectional Studies
Smoking
Alcohols
Demography
Hormones
Confidence Intervals
Education

Keywords

  • Biomarker
  • Longevity
  • MVPA
  • Minority aging
  • Postmenopausal

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Shadyab, Aladdin H. ; Lamonte, Michael J. ; Kooperberg, Charles ; Reiner, Alexander P. ; Carty, Cara L. ; Manini, Todd M. ; Hou, Lifang ; Di, Chongzhi ; Lacroix, Andrea Z. / Association of Accelerometer-Measured Physical Activity with Leukocyte Telomere Length among Older Women. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2017 ; Vol. 72, No. 11. pp. 1532-1537.
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abstract = "Background Previous studies on physical activity and telomere length have relied largely upon self-reported physical activity data, and few studies have examined older adults. The association of objectively measured physical activity with leukocyte telomere length (LTL) is currently unknown. Methods In this study, we examined cross-sectional associations between accelerometer-measured total, light, and moderate-to-vigorous physical activity (MVPA) and LTL, measured using Southern blot. The sample included 1,405 older (64-95 years old) white and African American women from the Women's Health Initiative. Multiple linear regression models adjusting for potential confounders were used to determine the association between accelerometer-measured physical activity and LTL. Results Overall, the mean (standard deviation) of total, light, and moderate-to-vigorous activity was 5.5 (1.6), 4.7 (1.3), and 0.8 (0.5) h/d, respectively. Adjusting for accelerometer wear time, age, race/ethnicity, education, marital status, smoking, alcohol, body mass index, a history of chronic diseases, and hormone therapy use, LTL was 80 (95{\%} confidence interval: 9, 150) base pairs longer among women with ≥2.5 compared with <2.5 h/wk of MVPA. Light activity was not significantly associated with LTL. For total activity, the most physically active women had significantly longer LTL than the least active women after adjustment for demographic and lifestyle characteristics; however, findings were not significant after further adjustment for health-related factors. Conclusions Older women meeting current recommendations of ≥2.5 h/wk of MVPA, as assessed by accelerometer, had longer LTL. Additional studies using accelerometers in large, diverse cohorts of older women are needed to confirm and extend these findings.",
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Association of Accelerometer-Measured Physical Activity with Leukocyte Telomere Length among Older Women. / Shadyab, Aladdin H.; Lamonte, Michael J.; Kooperberg, Charles; Reiner, Alexander P.; Carty, Cara L.; Manini, Todd M.; Hou, Lifang; Di, Chongzhi; Lacroix, Andrea Z.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 72, No. 11, 01.11.2017, p. 1532-1537.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of Accelerometer-Measured Physical Activity with Leukocyte Telomere Length among Older Women

AU - Shadyab, Aladdin H.

AU - Lamonte, Michael J.

AU - Kooperberg, Charles

AU - Reiner, Alexander P.

AU - Carty, Cara L.

AU - Manini, Todd M.

AU - Hou, Lifang

AU - Di, Chongzhi

AU - Lacroix, Andrea Z.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Background Previous studies on physical activity and telomere length have relied largely upon self-reported physical activity data, and few studies have examined older adults. The association of objectively measured physical activity with leukocyte telomere length (LTL) is currently unknown. Methods In this study, we examined cross-sectional associations between accelerometer-measured total, light, and moderate-to-vigorous physical activity (MVPA) and LTL, measured using Southern blot. The sample included 1,405 older (64-95 years old) white and African American women from the Women's Health Initiative. Multiple linear regression models adjusting for potential confounders were used to determine the association between accelerometer-measured physical activity and LTL. Results Overall, the mean (standard deviation) of total, light, and moderate-to-vigorous activity was 5.5 (1.6), 4.7 (1.3), and 0.8 (0.5) h/d, respectively. Adjusting for accelerometer wear time, age, race/ethnicity, education, marital status, smoking, alcohol, body mass index, a history of chronic diseases, and hormone therapy use, LTL was 80 (95% confidence interval: 9, 150) base pairs longer among women with ≥2.5 compared with <2.5 h/wk of MVPA. Light activity was not significantly associated with LTL. For total activity, the most physically active women had significantly longer LTL than the least active women after adjustment for demographic and lifestyle characteristics; however, findings were not significant after further adjustment for health-related factors. Conclusions Older women meeting current recommendations of ≥2.5 h/wk of MVPA, as assessed by accelerometer, had longer LTL. Additional studies using accelerometers in large, diverse cohorts of older women are needed to confirm and extend these findings.

AB - Background Previous studies on physical activity and telomere length have relied largely upon self-reported physical activity data, and few studies have examined older adults. The association of objectively measured physical activity with leukocyte telomere length (LTL) is currently unknown. Methods In this study, we examined cross-sectional associations between accelerometer-measured total, light, and moderate-to-vigorous physical activity (MVPA) and LTL, measured using Southern blot. The sample included 1,405 older (64-95 years old) white and African American women from the Women's Health Initiative. Multiple linear regression models adjusting for potential confounders were used to determine the association between accelerometer-measured physical activity and LTL. Results Overall, the mean (standard deviation) of total, light, and moderate-to-vigorous activity was 5.5 (1.6), 4.7 (1.3), and 0.8 (0.5) h/d, respectively. Adjusting for accelerometer wear time, age, race/ethnicity, education, marital status, smoking, alcohol, body mass index, a history of chronic diseases, and hormone therapy use, LTL was 80 (95% confidence interval: 9, 150) base pairs longer among women with ≥2.5 compared with <2.5 h/wk of MVPA. Light activity was not significantly associated with LTL. For total activity, the most physically active women had significantly longer LTL than the least active women after adjustment for demographic and lifestyle characteristics; however, findings were not significant after further adjustment for health-related factors. Conclusions Older women meeting current recommendations of ≥2.5 h/wk of MVPA, as assessed by accelerometer, had longer LTL. Additional studies using accelerometers in large, diverse cohorts of older women are needed to confirm and extend these findings.

KW - Biomarker

KW - Longevity

KW - MVPA

KW - Minority aging

KW - Postmenopausal

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U2 - 10.1093/gerona/glx037

DO - 10.1093/gerona/glx037

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