Association of antibody to human immunodeficiency virus type 1 core protein (p24), CD4+lymphocyte number, and aids-free time

Homayoon Farzadegan*, Joan S. Chmiel, Nancy Odaka, Linda Ward, Linda Poggensee, Alfred Saah, John P. Phair

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Serum antibody to p24 (anti-p24) and p24 antigen, alone and in combination with CD4+ lymphocyte number, were evaluated as predictors of progression of human immunodeficiency virus type 1 (HIV-1) infection. Two hundred six HIV-1-prevalent seropositive men in the Multicenter AIDS Cohort Study since 1984-1985 were studied cross-sectionally and 84 seroconverters were evaluated longitudinally. Cross-sectional analyses revealed significant associations among titer of anti-p24, CD4+cell count, disease status (Centers for Disease Control class), and progression to AIDS. A high titer of anti-p24 was associated with lack of p24 antigenemia. Longitudinal studies of seroconverters demonstrated that a low titer of anti-p24, low CD4+ cell count, and detection of HIV-1 p24 antigen are individually strong predictors of AIDS, but only low CD4+cell count retains its independent predictive value in multivariate analysis of the three markers during the period immediately after infection with HIV-1.

Original languageEnglish (US)
Pages (from-to)1217-1222
Number of pages6
JournalJournal of Infectious Diseases
Volume166
Issue number6
DOIs
StatePublished - Dec 1992

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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