Association of bleeding and thrombosis with outcome in extracorporeal life support

Heidi J. Dalton, Pamela Garcia-Filion, Richard Holubkov, Frank W. Moler, Thomas Shanley, Sabrina Heidemann, Kathleen Meert, Robert A. Berg, John Berger, Joseph Carcillo, Christopher Newth, Richard Harrison, Allan Doctor, Peter Rycus, J. Michael Dean, Tammara Jenkins, Carol Nicholson, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Collaborative Pediatric Critical Care Research Network

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

OBJECTIVE: Changes in technology and increased reports of successful extracorporeal life support use in patient populations, such as influenza, cardiac arrest, and adults, are leading to expansion of extracorporeal life support. Major limitations to extracorporeal life support expansion remain bleeding and thrombosis. These complications are the most frequent causes of death and morbidity. As a pilot project to provide baseline data for a detailed evaluation of bleeding and thrombosis in the current era, extracorporeal life support patients were analyzed from eight centers in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network. STUDY DESIGN: Retrospective analysis of patients (< 19 yr) reported to the Extracorporeal Life Support Organization registry from eight Collaborative Pediatric Critical Care Research Network centers between 2005 and 2011. SETTING: Tertiary children's hospitals within the Collaborative Pediatric Critical Care Research Network. SUBJECTS: The study cohort consisted of 2,036 patients (13% with congenital diaphragmatic hernia). INTERVENTIONS: None. MAIN RESULTS: In the cohort of patients without congenital diaphragmatic hernia (n = 1,773), bleeding occurred in 38% of patients, whereas thrombosis was noted in 31%. Bleeding and thrombosis were associated with a decreased survival by 40% (relative risk, 0.59; 95% CI, 0.53-0.66) and 33% (odds ratio, 0.67; 95% CI, 0.60-0.74). Longer duration of extracorporeal life support and use of venoarterial cannulation were also associated with increased risk of bleeding and/or thrombotic complications and lower survival. The most common bleeding events included surgical site bleeding (17%; n = 306), cannulation site bleeding (14%; n = 256), and intracranial hemorrhage (11%; n = 192). Common thrombotic events were clots in the circuit (15%; n = 274) and the oxygenator (12%; n = 212) and hemolysis (plasma-free hemoglobin > 50 mg/dL) (10%; n = 177). Among patients with congenital diaphragmatic hernia, bleeding and thrombosis occurred in, respectively, 45% (n = 118) and 60% (n = 159), Bleeding events were associated with reduced survival (relative risk, 0.62; 95% CI, 0.46-0.86) although thrombotic events were not (relative risk, 0.92; 95% CI, 0.67-1.26). CONCLUSIONS: Bleeding and thrombosis remain common complications in patients undergoing extracorporeal life support. Further research to reduce or eliminate bleeding and thrombosis is indicated to help improve patient outcome.

Original languageEnglish (US)
Pages (from-to)167-174
Number of pages8
JournalPediatric Critical Care Medicine
Volume16
Issue number2
DOIs
StatePublished - Feb 13 2015

Fingerprint

Extracorporeal Membrane Oxygenation
Thrombosis
Hemorrhage
National Institute of Child Health and Human Development (U.S.)
Critical Care
Heart Arrest
Research
Human Influenza
Cause of Death
Pediatrics
Technology
Morbidity
Survival
Population

Keywords

  • bleeding
  • cardiopulmonary bypass
  • complications
  • extracorporeal life support
  • extracorporeal membrane oxygenation
  • thrombosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Critical Care and Intensive Care Medicine

Cite this

Dalton, H. J., Garcia-Filion, P., Holubkov, R., Moler, F. W., Shanley, T., Heidemann, S., ... Collaborative Pediatric Critical Care Research Network (2015). Association of bleeding and thrombosis with outcome in extracorporeal life support. Pediatric Critical Care Medicine, 16(2), 167-174. https://doi.org/10.1097/PCC.0000000000000317
Dalton, Heidi J. ; Garcia-Filion, Pamela ; Holubkov, Richard ; Moler, Frank W. ; Shanley, Thomas ; Heidemann, Sabrina ; Meert, Kathleen ; Berg, Robert A. ; Berger, John ; Carcillo, Joseph ; Newth, Christopher ; Harrison, Richard ; Doctor, Allan ; Rycus, Peter ; Dean, J. Michael ; Jenkins, Tammara ; Nicholson, Carol ; Eunice Kennedy Shriver National Institute of Child Health and Human Development ; Collaborative Pediatric Critical Care Research Network. / Association of bleeding and thrombosis with outcome in extracorporeal life support. In: Pediatric Critical Care Medicine. 2015 ; Vol. 16, No. 2. pp. 167-174.
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abstract = "OBJECTIVE: Changes in technology and increased reports of successful extracorporeal life support use in patient populations, such as influenza, cardiac arrest, and adults, are leading to expansion of extracorporeal life support. Major limitations to extracorporeal life support expansion remain bleeding and thrombosis. These complications are the most frequent causes of death and morbidity. As a pilot project to provide baseline data for a detailed evaluation of bleeding and thrombosis in the current era, extracorporeal life support patients were analyzed from eight centers in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network. STUDY DESIGN: Retrospective analysis of patients (< 19 yr) reported to the Extracorporeal Life Support Organization registry from eight Collaborative Pediatric Critical Care Research Network centers between 2005 and 2011. SETTING: Tertiary children's hospitals within the Collaborative Pediatric Critical Care Research Network. SUBJECTS: The study cohort consisted of 2,036 patients (13{\%} with congenital diaphragmatic hernia). INTERVENTIONS: None. MAIN RESULTS: In the cohort of patients without congenital diaphragmatic hernia (n = 1,773), bleeding occurred in 38{\%} of patients, whereas thrombosis was noted in 31{\%}. Bleeding and thrombosis were associated with a decreased survival by 40{\%} (relative risk, 0.59; 95{\%} CI, 0.53-0.66) and 33{\%} (odds ratio, 0.67; 95{\%} CI, 0.60-0.74). Longer duration of extracorporeal life support and use of venoarterial cannulation were also associated with increased risk of bleeding and/or thrombotic complications and lower survival. The most common bleeding events included surgical site bleeding (17{\%}; n = 306), cannulation site bleeding (14{\%}; n = 256), and intracranial hemorrhage (11{\%}; n = 192). Common thrombotic events were clots in the circuit (15{\%}; n = 274) and the oxygenator (12{\%}; n = 212) and hemolysis (plasma-free hemoglobin > 50 mg/dL) (10{\%}; n = 177). Among patients with congenital diaphragmatic hernia, bleeding and thrombosis occurred in, respectively, 45{\%} (n = 118) and 60{\%} (n = 159), Bleeding events were associated with reduced survival (relative risk, 0.62; 95{\%} CI, 0.46-0.86) although thrombotic events were not (relative risk, 0.92; 95{\%} CI, 0.67-1.26). CONCLUSIONS: Bleeding and thrombosis remain common complications in patients undergoing extracorporeal life support. Further research to reduce or eliminate bleeding and thrombosis is indicated to help improve patient outcome.",
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Dalton, HJ, Garcia-Filion, P, Holubkov, R, Moler, FW, Shanley, T, Heidemann, S, Meert, K, Berg, RA, Berger, J, Carcillo, J, Newth, C, Harrison, R, Doctor, A, Rycus, P, Dean, JM, Jenkins, T, Nicholson, C, Eunice Kennedy Shriver National Institute of Child Health and Human Development & Collaborative Pediatric Critical Care Research Network 2015, 'Association of bleeding and thrombosis with outcome in extracorporeal life support', Pediatric Critical Care Medicine, vol. 16, no. 2, pp. 167-174. https://doi.org/10.1097/PCC.0000000000000317

Association of bleeding and thrombosis with outcome in extracorporeal life support. / Dalton, Heidi J.; Garcia-Filion, Pamela; Holubkov, Richard; Moler, Frank W.; Shanley, Thomas; Heidemann, Sabrina; Meert, Kathleen; Berg, Robert A.; Berger, John; Carcillo, Joseph; Newth, Christopher; Harrison, Richard; Doctor, Allan; Rycus, Peter; Dean, J. Michael; Jenkins, Tammara; Nicholson, Carol; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Collaborative Pediatric Critical Care Research Network.

In: Pediatric Critical Care Medicine, Vol. 16, No. 2, 13.02.2015, p. 167-174.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of bleeding and thrombosis with outcome in extracorporeal life support

AU - Dalton, Heidi J.

AU - Garcia-Filion, Pamela

AU - Holubkov, Richard

AU - Moler, Frank W.

AU - Shanley, Thomas

AU - Heidemann, Sabrina

AU - Meert, Kathleen

AU - Berg, Robert A.

AU - Berger, John

AU - Carcillo, Joseph

AU - Newth, Christopher

AU - Harrison, Richard

AU - Doctor, Allan

AU - Rycus, Peter

AU - Dean, J. Michael

AU - Jenkins, Tammara

AU - Nicholson, Carol

AU - Eunice Kennedy Shriver National Institute of Child Health and Human Development

AU - Collaborative Pediatric Critical Care Research Network

PY - 2015/2/13

Y1 - 2015/2/13

N2 - OBJECTIVE: Changes in technology and increased reports of successful extracorporeal life support use in patient populations, such as influenza, cardiac arrest, and adults, are leading to expansion of extracorporeal life support. Major limitations to extracorporeal life support expansion remain bleeding and thrombosis. These complications are the most frequent causes of death and morbidity. As a pilot project to provide baseline data for a detailed evaluation of bleeding and thrombosis in the current era, extracorporeal life support patients were analyzed from eight centers in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network. STUDY DESIGN: Retrospective analysis of patients (< 19 yr) reported to the Extracorporeal Life Support Organization registry from eight Collaborative Pediatric Critical Care Research Network centers between 2005 and 2011. SETTING: Tertiary children's hospitals within the Collaborative Pediatric Critical Care Research Network. SUBJECTS: The study cohort consisted of 2,036 patients (13% with congenital diaphragmatic hernia). INTERVENTIONS: None. MAIN RESULTS: In the cohort of patients without congenital diaphragmatic hernia (n = 1,773), bleeding occurred in 38% of patients, whereas thrombosis was noted in 31%. Bleeding and thrombosis were associated with a decreased survival by 40% (relative risk, 0.59; 95% CI, 0.53-0.66) and 33% (odds ratio, 0.67; 95% CI, 0.60-0.74). Longer duration of extracorporeal life support and use of venoarterial cannulation were also associated with increased risk of bleeding and/or thrombotic complications and lower survival. The most common bleeding events included surgical site bleeding (17%; n = 306), cannulation site bleeding (14%; n = 256), and intracranial hemorrhage (11%; n = 192). Common thrombotic events were clots in the circuit (15%; n = 274) and the oxygenator (12%; n = 212) and hemolysis (plasma-free hemoglobin > 50 mg/dL) (10%; n = 177). Among patients with congenital diaphragmatic hernia, bleeding and thrombosis occurred in, respectively, 45% (n = 118) and 60% (n = 159), Bleeding events were associated with reduced survival (relative risk, 0.62; 95% CI, 0.46-0.86) although thrombotic events were not (relative risk, 0.92; 95% CI, 0.67-1.26). CONCLUSIONS: Bleeding and thrombosis remain common complications in patients undergoing extracorporeal life support. Further research to reduce or eliminate bleeding and thrombosis is indicated to help improve patient outcome.

AB - OBJECTIVE: Changes in technology and increased reports of successful extracorporeal life support use in patient populations, such as influenza, cardiac arrest, and adults, are leading to expansion of extracorporeal life support. Major limitations to extracorporeal life support expansion remain bleeding and thrombosis. These complications are the most frequent causes of death and morbidity. As a pilot project to provide baseline data for a detailed evaluation of bleeding and thrombosis in the current era, extracorporeal life support patients were analyzed from eight centers in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network. STUDY DESIGN: Retrospective analysis of patients (< 19 yr) reported to the Extracorporeal Life Support Organization registry from eight Collaborative Pediatric Critical Care Research Network centers between 2005 and 2011. SETTING: Tertiary children's hospitals within the Collaborative Pediatric Critical Care Research Network. SUBJECTS: The study cohort consisted of 2,036 patients (13% with congenital diaphragmatic hernia). INTERVENTIONS: None. MAIN RESULTS: In the cohort of patients without congenital diaphragmatic hernia (n = 1,773), bleeding occurred in 38% of patients, whereas thrombosis was noted in 31%. Bleeding and thrombosis were associated with a decreased survival by 40% (relative risk, 0.59; 95% CI, 0.53-0.66) and 33% (odds ratio, 0.67; 95% CI, 0.60-0.74). Longer duration of extracorporeal life support and use of venoarterial cannulation were also associated with increased risk of bleeding and/or thrombotic complications and lower survival. The most common bleeding events included surgical site bleeding (17%; n = 306), cannulation site bleeding (14%; n = 256), and intracranial hemorrhage (11%; n = 192). Common thrombotic events were clots in the circuit (15%; n = 274) and the oxygenator (12%; n = 212) and hemolysis (plasma-free hemoglobin > 50 mg/dL) (10%; n = 177). Among patients with congenital diaphragmatic hernia, bleeding and thrombosis occurred in, respectively, 45% (n = 118) and 60% (n = 159), Bleeding events were associated with reduced survival (relative risk, 0.62; 95% CI, 0.46-0.86) although thrombotic events were not (relative risk, 0.92; 95% CI, 0.67-1.26). CONCLUSIONS: Bleeding and thrombosis remain common complications in patients undergoing extracorporeal life support. Further research to reduce or eliminate bleeding and thrombosis is indicated to help improve patient outcome.

KW - bleeding

KW - cardiopulmonary bypass

KW - complications

KW - extracorporeal life support

KW - extracorporeal membrane oxygenation

KW - thrombosis

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