Association of bullous pemphigoid and comorbid health conditions: a case–control study

Sherry Lee, Supriya Rastogi, Derek Y. Hsu, Beatrice Nardone, Jonathan I Silverberg*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Background: Bullous pemphigoid is an autoimmune skin disease characterized by the formation of blisters between the epidermis and dermis. Comorbidities of pemphigoid have not been well-described. Identification of comorbidities associated with pemphigoid is important to decrease morbidity and mortality. Objective: To identify the comorbid health conditions of bullous pemphigoid. Methods: This was a case–control study of 91 cases of pemphigoid verified by clinical and laboratory diagnosis and 546 age- and sex-matched controls with complete follow-up at a large metropolitan quaternary care medical center. Results: The average age of bullous pemphigoid patients was 76 years and 53% of patients were female. Forty-eight (53%) of the BP patients had a history of inpatient hospitalization, of which 22 (24.2%) were hospitalized for either previously undiagnosed BP or an exacerbation of BP. Bullous pemphigoid was significantly associated with hypertension [adjusted odds ratio (95% confidence interval)]: [2.03 (1.24–3.32)], diabetes mellitus [2.59 (1.60–4.19)], chronic kidney disease [2.29 (1.19–4.40)], end-stage renal disease [3.82 (1.48–9.85)], basal cell carcinoma of the skin [6.00 (1.94–18.6)], and obstructive sleep apnea [5.23 (2.45–11.19)]. 78% of BP patients used at least one systemic immunosuppressant. There was no significant association between treatments for pemphigoid and any of the comorbidities. Conclusions: Bullous pemphigoid patients need screening for comorbid health conditions even though treatment options do not seem to be associated with these comorbidities.

Original languageEnglish (US)
JournalArchives of Dermatological Research
DOIs
StateAccepted/In press - 2020

Keywords

  • Autoimmune
  • Blister
  • Bullous
  • Burden
  • Cancer
  • Cardiovascular
  • Epidemiology
  • Health
  • Hospitalization
  • Pemphigoid

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'Association of bullous pemphigoid and comorbid health conditions: a case–control study'. Together they form a unique fingerprint.

  • Cite this