Abstract
Assessing the association of the newborn metabolic state with severity of subsequent respiratory tract infection may provide important insights on infection pathogenesis. In this multi-site birth cohort study, we identified newborn metabolites associated with lower respiratory tract infection (LRTI) in the first year of life in a discovery cohort and assessed for replication in two independent cohorts. Increased citrulline concentration was associated with decreased odds of LRTI (discovery cohort: aOR 0.83 [95% CI 0.70–0.99], p = 0.04; replication cohorts: aOR 0.58 [95% CI 0.28–1.22], p = 0.15). While our findings require further replication and investigation of mechanisms of action, they identify a novel target for LRTI prevention and treatment.
| Original language | English (US) |
|---|---|
| Article number | 979777 |
| Journal | Frontiers in Pediatrics |
| Volume | 10 |
| DOIs | |
| State | Published - Oct 17 2022 |
Funding
This work was supported by the National Institutes of Health (grant numbers UG3/UH3 OD023282 and U19 AI104317 to JEG, UH3 OD023282 and U19 AI095227 to TVH, P01 AI089473 to EMZ, and K01 HL161257 which supports BMS) (https://www.nih.gov/). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments
Keywords
- citrulline
- infancy
- lower respiratory tract infection
- metabolites
- newborn screening (NBS)
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health