Association of citrulline concentration at birth with lower respiratory tract infection in infancy: Findings from a multi-site birth cohort study

on behalf of the ECHO-CREW investigators

Research output: Contribution to journalArticlepeer-review

Abstract

Assessing the association of the newborn metabolic state with severity of subsequent respiratory tract infection may provide important insights on infection pathogenesis. In this multi-site birth cohort study, we identified newborn metabolites associated with lower respiratory tract infection (LRTI) in the first year of life in a discovery cohort and assessed for replication in two independent cohorts. Increased citrulline concentration was associated with decreased odds of LRTI (discovery cohort: aOR 0.83 [95% CI 0.70–0.99], p = 0.04; replication cohorts: aOR 0.58 [95% CI 0.28–1.22], p = 0.15). While our findings require further replication and investigation of mechanisms of action, they identify a novel target for LRTI prevention and treatment.

Original languageEnglish (US)
Article number979777
JournalFrontiers in Pediatrics
Volume10
DOIs
StatePublished - Oct 17 2022

Keywords

  • citrulline
  • infancy
  • lower respiratory tract infection
  • metabolites
  • newborn screening (NBS)

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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