Association of cord blood magnesium concentration and neonatal resuscitation

Lynn H. Johnson*, Delicia C. Mapp, Dwight J. Rouse, Catherine Y. Spong, Brian M. Mercer, Kenneth J. Leveno, Michael W. Varner, Jay D. Iams, Yoram Sorokin, Susan M. Ramin, Menachem Miodovnik, Mary J. O'Sullivan, Alan M Peaceman, Steve N. Caritis

*Corresponding author for this work

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objective: To assess the relationship between umbilical cord blood magnesium concentration and level of delivery room resuscitation received by neonates. Study design: This was a secondary analysis of a controlled fetal neuroprotection trial that enrolled women at imminent risk for delivery between 24 and 31 weeks' gestation and randomly allocated them to receive either intravenous magnesium sulfate or placebo. The cohort included 1507 infants with data available on total cord blood Mg concentration and delivery room resuscitation. Multivariate logistic regression was used to estimate the association between cord blood Mg concentration and highest level of delivery room resuscitation, using the following hierarchy: none, oxygen only, bag-mask ventilation with oxygen, intubation, and chest compressions. Results: There was no relationship between cord blood Mg and delivery room resuscitation (OR, 0.92 for each 1.0-mEq/L increase in Mg; 95% CI, 0.83-1.03). Maternal general anesthesia was associated with increased neonatal resuscitation (OR, 2.51; 95% CI, 1.72-3.68). Each 1-week increase in gestational age at birth was associated with decreased neonatal resuscitation (OR, 0.63; 95% CI, 0.60-0.66). Conclusion: Cord blood Mg concentration does not correlate with the level of delivery room resuscitation of infants exposed to magnesium sulfate for fetal neuroprotection.

Original languageEnglish (US)
JournalJournal of Pediatrics
Volume160
Issue number4
DOIs
StatePublished - Jan 1 2012

Fingerprint

Fetal Blood
Delivery Rooms
Resuscitation
Magnesium
Magnesium Sulfate
Oxygen
Masks
Intubation
General Anesthesia
Gestational Age
Thorax
Logistic Models
Placebos
Mothers
Parturition
Newborn Infant
Pregnancy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Johnson, L. H., Mapp, D. C., Rouse, D. J., Spong, C. Y., Mercer, B. M., Leveno, K. J., ... Caritis, S. N. (2012). Association of cord blood magnesium concentration and neonatal resuscitation. Journal of Pediatrics, 160(4). https://doi.org/10.1016/j.jpeds.2011.09.016
Johnson, Lynn H. ; Mapp, Delicia C. ; Rouse, Dwight J. ; Spong, Catherine Y. ; Mercer, Brian M. ; Leveno, Kenneth J. ; Varner, Michael W. ; Iams, Jay D. ; Sorokin, Yoram ; Ramin, Susan M. ; Miodovnik, Menachem ; O'Sullivan, Mary J. ; Peaceman, Alan M ; Caritis, Steve N. / Association of cord blood magnesium concentration and neonatal resuscitation. In: Journal of Pediatrics. 2012 ; Vol. 160, No. 4.
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abstract = "Objective: To assess the relationship between umbilical cord blood magnesium concentration and level of delivery room resuscitation received by neonates. Study design: This was a secondary analysis of a controlled fetal neuroprotection trial that enrolled women at imminent risk for delivery between 24 and 31 weeks' gestation and randomly allocated them to receive either intravenous magnesium sulfate or placebo. The cohort included 1507 infants with data available on total cord blood Mg concentration and delivery room resuscitation. Multivariate logistic regression was used to estimate the association between cord blood Mg concentration and highest level of delivery room resuscitation, using the following hierarchy: none, oxygen only, bag-mask ventilation with oxygen, intubation, and chest compressions. Results: There was no relationship between cord blood Mg and delivery room resuscitation (OR, 0.92 for each 1.0-mEq/L increase in Mg; 95{\%} CI, 0.83-1.03). Maternal general anesthesia was associated with increased neonatal resuscitation (OR, 2.51; 95{\%} CI, 1.72-3.68). Each 1-week increase in gestational age at birth was associated with decreased neonatal resuscitation (OR, 0.63; 95{\%} CI, 0.60-0.66). Conclusion: Cord blood Mg concentration does not correlate with the level of delivery room resuscitation of infants exposed to magnesium sulfate for fetal neuroprotection.",
author = "Johnson, {Lynn H.} and Mapp, {Delicia C.} and Rouse, {Dwight J.} and Spong, {Catherine Y.} and Mercer, {Brian M.} and Leveno, {Kenneth J.} and Varner, {Michael W.} and Iams, {Jay D.} and Yoram Sorokin and Ramin, {Susan M.} and Menachem Miodovnik and O'Sullivan, {Mary J.} and Peaceman, {Alan M} and Caritis, {Steve N.}",
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Johnson, LH, Mapp, DC, Rouse, DJ, Spong, CY, Mercer, BM, Leveno, KJ, Varner, MW, Iams, JD, Sorokin, Y, Ramin, SM, Miodovnik, M, O'Sullivan, MJ, Peaceman, AM & Caritis, SN 2012, 'Association of cord blood magnesium concentration and neonatal resuscitation', Journal of Pediatrics, vol. 160, no. 4. https://doi.org/10.1016/j.jpeds.2011.09.016

Association of cord blood magnesium concentration and neonatal resuscitation. / Johnson, Lynn H.; Mapp, Delicia C.; Rouse, Dwight J.; Spong, Catherine Y.; Mercer, Brian M.; Leveno, Kenneth J.; Varner, Michael W.; Iams, Jay D.; Sorokin, Yoram; Ramin, Susan M.; Miodovnik, Menachem; O'Sullivan, Mary J.; Peaceman, Alan M; Caritis, Steve N.

In: Journal of Pediatrics, Vol. 160, No. 4, 01.01.2012.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of cord blood magnesium concentration and neonatal resuscitation

AU - Johnson, Lynn H.

AU - Mapp, Delicia C.

AU - Rouse, Dwight J.

AU - Spong, Catherine Y.

AU - Mercer, Brian M.

AU - Leveno, Kenneth J.

AU - Varner, Michael W.

AU - Iams, Jay D.

AU - Sorokin, Yoram

AU - Ramin, Susan M.

AU - Miodovnik, Menachem

AU - O'Sullivan, Mary J.

AU - Peaceman, Alan M

AU - Caritis, Steve N.

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Objective: To assess the relationship between umbilical cord blood magnesium concentration and level of delivery room resuscitation received by neonates. Study design: This was a secondary analysis of a controlled fetal neuroprotection trial that enrolled women at imminent risk for delivery between 24 and 31 weeks' gestation and randomly allocated them to receive either intravenous magnesium sulfate or placebo. The cohort included 1507 infants with data available on total cord blood Mg concentration and delivery room resuscitation. Multivariate logistic regression was used to estimate the association between cord blood Mg concentration and highest level of delivery room resuscitation, using the following hierarchy: none, oxygen only, bag-mask ventilation with oxygen, intubation, and chest compressions. Results: There was no relationship between cord blood Mg and delivery room resuscitation (OR, 0.92 for each 1.0-mEq/L increase in Mg; 95% CI, 0.83-1.03). Maternal general anesthesia was associated with increased neonatal resuscitation (OR, 2.51; 95% CI, 1.72-3.68). Each 1-week increase in gestational age at birth was associated with decreased neonatal resuscitation (OR, 0.63; 95% CI, 0.60-0.66). Conclusion: Cord blood Mg concentration does not correlate with the level of delivery room resuscitation of infants exposed to magnesium sulfate for fetal neuroprotection.

AB - Objective: To assess the relationship between umbilical cord blood magnesium concentration and level of delivery room resuscitation received by neonates. Study design: This was a secondary analysis of a controlled fetal neuroprotection trial that enrolled women at imminent risk for delivery between 24 and 31 weeks' gestation and randomly allocated them to receive either intravenous magnesium sulfate or placebo. The cohort included 1507 infants with data available on total cord blood Mg concentration and delivery room resuscitation. Multivariate logistic regression was used to estimate the association between cord blood Mg concentration and highest level of delivery room resuscitation, using the following hierarchy: none, oxygen only, bag-mask ventilation with oxygen, intubation, and chest compressions. Results: There was no relationship between cord blood Mg and delivery room resuscitation (OR, 0.92 for each 1.0-mEq/L increase in Mg; 95% CI, 0.83-1.03). Maternal general anesthesia was associated with increased neonatal resuscitation (OR, 2.51; 95% CI, 1.72-3.68). Each 1-week increase in gestational age at birth was associated with decreased neonatal resuscitation (OR, 0.63; 95% CI, 0.60-0.66). Conclusion: Cord blood Mg concentration does not correlate with the level of delivery room resuscitation of infants exposed to magnesium sulfate for fetal neuroprotection.

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