Association of dermatomyositis with systemic and opportunistic infections in the United States

Ziyou Ren, Anne E. Laumann, Jonathan I Silverberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Patients with dermatomyositis have multiple risk factors for serious and opportunistic infections, including immune dysregulation, long-term systemic corticosteroid treatment and comorbid health conditions. We sought to determine whether dermatomyositis is associated with increased odds and burden of systemic, opportunistic and antibiotic-resistant infections. We analyzed data from the Nationwide Inpatient Sample from 2002 to 2012, containing a cross-sectional representative 20% sample of all hospitalizations in the US. Overall, dermatomyositis was associated with serious infections in adults (multivariable logistic regression; adjusted odds ratio [95% confidence interval]: 2.19 [2.08–2.30]) and children (1.45 [1.20–1.76]). In particular, dermatomyositis was significantly associated with 32 of 48 and 15 of 48 infections examined in adults and children, respectively, including infections of skin, bone, joints, brain, heart, lungs, and gastrointestinal system, as well sepsis, antibiotic-resistant and opportunistic infections. Predictors of infections included non-white race/ethnicity, insurance status, history of long-term systemic corticosteroid usage, Cushing’s syndrome (likely secondary to corticosteroid usage), diabetes, and cancer. Serious infections were associated with significantly increased inpatient cost and death in dermatomyositis patients. In conclusion, dermatomyositis is associated with higher odds, costs and inpatient mortality from serious and opportunistic infections.

Original languageEnglish (US)
Pages (from-to)377-387
Number of pages11
JournalArchives of Dermatological Research
Issue number5
StatePublished - Jul 5 2019


  • Cryptococcus
  • Cytomegalovirus
  • Dermatomyositis
  • Epidemiology
  • Hepatitis A virus
  • Hospitalization
  • Infection
  • Inpatient
  • Long-term steroid use
  • Opportunistic
  • Pneumocystis

ASJC Scopus subject areas

  • Dermatology


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