TY - JOUR
T1 - Association of high dietary saturated fat intake and uncontrolled diabetes with constipation
T2 - Evidence from the National Health and Nutrition Examination Survey
AU - Taba Taba Vakili, S.
AU - Nezami, B. G.
AU - Shetty, A.
AU - Chetty, V. K.
AU - Srinivasan, S.
N1 - Publisher Copyright:
© 2015 John Wiley & Sons Ltd.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Background: Constipation is highly prevalent in the United States. The association of dietary fat intake with constipation has not been well studied. We recently reported that mice fed a high-fat diet had higher incidence of constipation than regular diet fed mice. The aim of this study was to assess if increased intake of dietary saturated fat in humans is also associated with higher risk of constipation and reduced stool frequency. Methods: Analyses were based on data from 6207 adults (≥20 years) from the 2005-2006 and 2007-2008 cycles of the National Health and Nutrition Examination Surveys who had completed the bowel health questionnaire. Constipation was defined as a stool frequency of less than three times per week. Multivariable logistic regression analysis was used to calculate adjusted prevalence odds ratio (OR) estimates. Statistical analyses were performed using R and RStudio softwares. Key Results: The prevalence of constipation in this sample was 3.1%. After multivariable adjustment high saturated fat remained associated with constipation. The OR for high saturated fat intake associated with constipation was much higher in diabetics above 65 years, especially in non-Hispanic blacks, females, and those with poor glycemic control, compared to the control group. Conclusions & Inferences: To the best of our knowledge, this is the first report to investigate the association of high saturated fat diet, bowel frequency, and diabetes. This study demonstrates that a high dietary saturated fat intake is associated with significant increase in the prevalence of constipation, especially in the uncontrolled diabetic, non-Hispanic black, female patients. Education on dietary fat control in the people consuming high-fat diets might be worthwhile, particularly in elderly and diabetic patients, who are at higher risk of constipation. Present findings provide new evidence supporting dietary recommendations to consume diets that have low saturated fat, specifically in those who suffer from constipation. After multivariable adjustment, high saturated fat remained associated with constipation. The odds ratio for high saturated fat intake associated with constipation was much higher in diabetics greater than 65 years old, especially those with poor glycemic control, non-Hispanic blacks and females, compared to the control group.
AB - Background: Constipation is highly prevalent in the United States. The association of dietary fat intake with constipation has not been well studied. We recently reported that mice fed a high-fat diet had higher incidence of constipation than regular diet fed mice. The aim of this study was to assess if increased intake of dietary saturated fat in humans is also associated with higher risk of constipation and reduced stool frequency. Methods: Analyses were based on data from 6207 adults (≥20 years) from the 2005-2006 and 2007-2008 cycles of the National Health and Nutrition Examination Surveys who had completed the bowel health questionnaire. Constipation was defined as a stool frequency of less than three times per week. Multivariable logistic regression analysis was used to calculate adjusted prevalence odds ratio (OR) estimates. Statistical analyses were performed using R and RStudio softwares. Key Results: The prevalence of constipation in this sample was 3.1%. After multivariable adjustment high saturated fat remained associated with constipation. The OR for high saturated fat intake associated with constipation was much higher in diabetics above 65 years, especially in non-Hispanic blacks, females, and those with poor glycemic control, compared to the control group. Conclusions & Inferences: To the best of our knowledge, this is the first report to investigate the association of high saturated fat diet, bowel frequency, and diabetes. This study demonstrates that a high dietary saturated fat intake is associated with significant increase in the prevalence of constipation, especially in the uncontrolled diabetic, non-Hispanic black, female patients. Education on dietary fat control in the people consuming high-fat diets might be worthwhile, particularly in elderly and diabetic patients, who are at higher risk of constipation. Present findings provide new evidence supporting dietary recommendations to consume diets that have low saturated fat, specifically in those who suffer from constipation. After multivariable adjustment, high saturated fat remained associated with constipation. The odds ratio for high saturated fat intake associated with constipation was much higher in diabetics greater than 65 years old, especially those with poor glycemic control, non-Hispanic blacks and females, compared to the control group.
KW - Constipation
KW - Diabetes
KW - High-fat diet
KW - NHANES
KW - Stool frequency
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U2 - 10.1111/nmo.12630
DO - 10.1111/nmo.12630
M3 - Article
C2 - 26176421
AN - SCOPUS:84942237978
SN - 1350-1925
VL - 27
SP - 1389
EP - 1397
JO - Neurogastroenterology and Motility
JF - Neurogastroenterology and Motility
IS - 10
ER -