TY - JOUR
T1 - Association of lipoprotein-associated phospholipase A2 and endothelial function in the Multi-Ethnic Study of Atherosclerosis (MESA)
AU - Garg, Parveen K.
AU - McClelland, Robyn L.
AU - Jenny, Nancy S.
AU - Criqui, Michael
AU - Liu, Kiang
AU - Polak, Joseph F.
AU - Jorgensen, Neal W.
AU - Cushman, Mary
PY - 2011/8/1
Y1 - 2011/8/1
N2 - Mechanisms underlying the role of lipoprotein-associated phospholipase A 2 (L p-PLA 2) in atherosclerotic development are not completely understood. We evaluated the relationship of Lp-PLA 2 with endothelial dysfunction, an early manifestation of atherosclerosis, in a cohort without known clinical cardiovascular disease. A total of 2809 participants in the Multi-Ethnic Study of Atherosclerosis underwent plasma L p-PLA 2 mass and activity measurement and brachial artery flow-mediated vasodilation testing. In adjusted linear regression models, higher L p-PLA 2 mass and activity levels were not associated with lower endothelial function ( -0.04%, p = 0.51 and -0.09%, p = 0.10, respectively). Among individuals with subclinical atherosclerosis based on ankle-brachial index (ABI) or carotid intima-media thickness (IMT), L p-PLA 2 mass and activity were not associated with lower endothelial function ( -0.03%, p = 0.88 and -0.31%, p = 0.16 for ABI < 1.00; 0.01%, p = 0.94 and -0.15%, p = 0.20 for abnormal carotid IMT). In summary, L p-PLA 2 is not associated with endothelial dysfunction, suggesting its role in atherosclerosis development is primarily related to other factors.
AB - Mechanisms underlying the role of lipoprotein-associated phospholipase A 2 (L p-PLA 2) in atherosclerotic development are not completely understood. We evaluated the relationship of Lp-PLA 2 with endothelial dysfunction, an early manifestation of atherosclerosis, in a cohort without known clinical cardiovascular disease. A total of 2809 participants in the Multi-Ethnic Study of Atherosclerosis underwent plasma L p-PLA 2 mass and activity measurement and brachial artery flow-mediated vasodilation testing. In adjusted linear regression models, higher L p-PLA 2 mass and activity levels were not associated with lower endothelial function ( -0.04%, p = 0.51 and -0.09%, p = 0.10, respectively). Among individuals with subclinical atherosclerosis based on ankle-brachial index (ABI) or carotid intima-media thickness (IMT), L p-PLA 2 mass and activity were not associated with lower endothelial function ( -0.03%, p = 0.88 and -0.31%, p = 0.16 for ABI < 1.00; 0.01%, p = 0.94 and -0.15%, p = 0.20 for abnormal carotid IMT). In summary, L p-PLA 2 is not associated with endothelial dysfunction, suggesting its role in atherosclerosis development is primarily related to other factors.
KW - Lp-PLA2
KW - ankle-brachial index
KW - atherosclerosis
KW - carotid intimal-medial thickness
KW - endothelial function
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U2 - 10.1177/1358863X11411360
DO - 10.1177/1358863X11411360
M3 - Article
C2 - 21708876
AN - SCOPUS:80051636445
VL - 16
SP - 247
EP - 252
JO - Vascular Medicine
JF - Vascular Medicine
SN - 1358-863X
IS - 4
ER -