Association of lipoprotein-associated phospholipase A2 and endothelial function in the Multi-Ethnic Study of Atherosclerosis (MESA)

Parveen K. Garg*, Robyn L. McClelland, Nancy S. Jenny, Michael Criqui, Kiang Liu, Joseph F. Polak, Neal W. Jorgensen, Mary Cushman

*Corresponding author for this work

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Mechanisms underlying the role of lipoprotein-associated phospholipase A 2 (L p-PLA 2) in atherosclerotic development are not completely understood. We evaluated the relationship of Lp-PLA 2 with endothelial dysfunction, an early manifestation of atherosclerosis, in a cohort without known clinical cardiovascular disease. A total of 2809 participants in the Multi-Ethnic Study of Atherosclerosis underwent plasma L p-PLA 2 mass and activity measurement and brachial artery flow-mediated vasodilation testing. In adjusted linear regression models, higher L p-PLA 2 mass and activity levels were not associated with lower endothelial function ( -0.04%, p = 0.51 and -0.09%, p = 0.10, respectively). Among individuals with subclinical atherosclerosis based on ankle-brachial index (ABI) or carotid intima-media thickness (IMT), L p-PLA 2 mass and activity were not associated with lower endothelial function ( -0.03%, p = 0.88 and -0.31%, p = 0.16 for ABI < 1.00; 0.01%, p = 0.94 and -0.15%, p = 0.20 for abnormal carotid IMT). In summary, L p-PLA 2 is not associated with endothelial dysfunction, suggesting its role in atherosclerosis development is primarily related to other factors.

Original languageEnglish (US)
Pages (from-to)247-252
Number of pages6
JournalVascular Medicine
Volume16
Issue number4
DOIs
StatePublished - Aug 1 2011

Keywords

  • Lp-PLA2
  • ankle-brachial index
  • atherosclerosis
  • carotid intimal-medial thickness
  • endothelial function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Garg, P. K., McClelland, R. L., Jenny, N. S., Criqui, M., Liu, K., Polak, J. F., Jorgensen, N. W., & Cushman, M. (2011). Association of lipoprotein-associated phospholipase A2 and endothelial function in the Multi-Ethnic Study of Atherosclerosis (MESA). Vascular Medicine, 16(4), 247-252. https://doi.org/10.1177/1358863X11411360