Association of lower urinary tract symptoms based on the international prostate symptom score and cardiovascular disease

Yoshihiro Tanaka*, Satoko Matsuyama, Hayato Tada, Kenshi Hayashi, Masayuki Takamura, Masa Aki Kawashiri, Rod Passman, Philip Greenland

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background: Because it is unclear whether lower urinary tract symptoms (LUTS) are associated with cardiovascular disease (CVD) in the Japanese population, we explored the association in general Japanese men aged 55-75 years. Methods and Results: The cross-sectional study included male participants who had both national health checkup data and the International Prostate Symptom Score (IPSS) in the same calendar year between 2009 and 2017. LUTS severity was evaluated by IPSS. A robust Poisson regression model was used to assess the association between LUTS severity and the composite CVD outcome [coronary artery disease (CAD), stroke, or atrial fibrillation (AF)] and each component of the composite outcome. Prevalence ratio (PR) was adjusted for conventional cardiovascular risk factors. Of 16,781 male participants (mean age, 67 }5 years), mild LUTS were observed in 9,243 (55.1%); moderate, 6,445 (38.4%); and severe, 1,093 (6.5%). Compared with the mild LUTS group, moderate LUTS [PR 1.18, 95% confidence interval (CI) 1.10-1.25, P<0.001] and severe LUTS (PR 1.38, 95% CI 1.24-1.53, P<0.001) were significantly associated with a higher prevalence of CVD. LUTS severity was associated with higher prevalence of CAD and stroke, but not AF. Conclusions: The severity of LUTS was associated with a higher prevalence of CVD, especially CAD and stroke, independent of conventional CVD risk factors.

Original languageEnglish (US)
Pages (from-to)2092-2099
Number of pages8
JournalCirculation Journal
Issue number11
StatePublished - 2021


  • Atrial fibrillation
  • Cardiovascular disease
  • Coronary artery disease
  • Lower urinary tract symptoms
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Association of lower urinary tract symptoms based on the international prostate symptom score and cardiovascular disease'. Together they form a unique fingerprint.

Cite this