Abstract
Objective: To compare the rates of death or survival with severe neurodevelopmental impairment (sNDI) at 2 years among extremely preterm infants in relation to pre-pregnancy or first-trimester maternal body mass index (BMI). Methods: This retrospective cohort study included extremely preterm infants (gestational age 220/7–266/7 weeks). The study was conducted at National Institute of Child Health and Human Development Neonatal Research Network sites. The primary outcome was death or sNDI at 2 years. Results: Data on the primary outcome were available for 1208 children. Death or sNDI was not different among the three groups: 54.9% in normal, 56.1% in overweight, and 53.4% in obese group (p = 0.39). There was no significant difference in mortality, sNDI, moderate/severe cerebral palsy, Bayley Scales of Infant Development (BSID)-III cognitive composite score <70, BSID-III language composite score <70 in adjusted models. Conclusion: Neurodevelopmental outcome was not significantly associated with maternal pre-pregnancy BMI among extreme preterm infants.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 802-810 |
| Number of pages | 9 |
| Journal | Journal of Perinatology |
| Volume | 44 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 2024 |
Funding
The National Institutes of Health and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) provided grant support for the Neonatal Research Network for the Generic Database and the Follow-up Study. NICHD staff provided input into the study design, conduct, analysis, and manuscript drafting; NCATS cooperative agreements provided infrastructure support to the NRN. While NICHD staff had input into the study design, conduct, analysis, and manuscript drafting, the comments and views of the authors do not necessarily represent the views of NICHD, the National Institutes of Health, the Department of Health and Human Services, or the U.S. Government. Data collected at participating sites of the NICHD Neonatal Research Network were transmitted to RTI International, the data coordinating center (DCC) for the network, which stored, managed, and analyzed the data included in this study. On behalf of the NRN, RTI International had full access to all the data in the study and take responsibility for the integrity of the data and accuracy of the data analysis. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. We are indebted to our medical and nursing colleagues and the infants and their parents who agreed to take part in this study. The following investigators, in addition to those listed as authors, participated in this study: NRN Steering Committee Chair: Richard A. Polin, MD, Division of Neonatology, College of Physicians and Surgeons, Columbia University. Alpert Medical School of Brown University and Women & Infants Hospital of Rhode Island (UG1 HD27904) \u2013 Martin Keszler, MD; Angelita M. Hensman, PhD RNC-NIC; Elisa Vieira, BSN RN; Lucille St. Pierre, BS; Barbara Alksninis, RNC PNP; Andrea Knoll; Mary L. Keszler, MD; Teresa M. Leach, MEd CAES; Elisabeth C. McGowan, MD; Victoria E. Watson, MS CAS. Case Western Reserve University, Rainbow Babies & Children\u2019s Hospital (UG1 HD21364) \u2013 Michele C. Walsh, MD MS; Anna Maria Hibbs, MD MSCE; Nancy S. Newman, RN; Deanne E. Wilson-Costello, MD; Bonnie S. Siner, RN; Elizabeth Roth, MD. Children\u2019s Mercy Hospital (UG1 HD68284) \u2013 William E. Truog, MD; Eugenia K. Pallotto, MD MSCE; Howard W. Kilbride MD; Cheri Gauldin, RN BS CCRC; Anne Holmes RN MSN MBA-HCM CCRC; Allison Scott, BSN RNC-NIC; Prabhu S. Parimi, MD; Lisa Gaetano, RN MSN. Cincinnati Children\u2019s Hospital Medical Center, University Hospital, and Good Samaritan Hospital (UG1 HD27853, UL1 TR77) \u2013 Stephanie L. Merhar, MD MS; Brenda B. Poindexter, MD MS; Kurt Schibler, MD; Tanya E. Cahill, MD; David Russell, JD; Cathy Grisby, BSN CCRC; Kristin Kirker, CRC; Sandra Wuertz, RN BSN CLC; Juanita Dudley, RN BSN; Julia Thompson, RN BSN; Sara Stacey, BA; Devan Hayes, BS. Duke University School of Medicine, University Hospital, University of North Carolina, Duke Regional Hospital, and WakeMed Health & Hospitals (UG1 HD40492, UL1 TR1117) \u2013 C. Michael Cotten, MD MHS; Ronald N. Goldberg, MD; William F. Malcolm, MD; Patricia L. Ashley, MD; Deesha Mago-Shah, MD; Mollie Warren, MD; Joanne Finkle, RN JD; Kimberley A. Fisher, PhD FNP-BC IBCLC; Kathryn E. Gustafson, PhD; Matthew M. Laughon, MD MPH; Carl L. Bose, MD; Janice Bernhardt, MS RN; Gennie Bose, RN; Janice Wereszczak, CPNP-AC/PC; Andrea Trembath, MD MPH; Jennifer Talbert, MS RN; Stephen D. Kicklighter, MD; Alexandra Bentley, MD; Laura Edwards, MD; Ginger Rhodes-Ryan, ARNP MSN, NNP-BC; Donna White, RN-BC BSN. Emory University, Children\u2019s Healthcare of Atlanta, Grady Memorial Hospital, and Emory University Hospital Midtown (UG1 HD27851, UL1 TR454) \u2013 Ravi M. Patel, MD MSc; David P. Carlton, MD; Ira Adams-Chapman, MD (deceased); Yvonne Loggins, RN; Diane Bottcher, RN; Sheena L. Carter, PhD; Salathiel Kendrick-Allwood, MD; Maureen Mulligan LaRossa, RN; Judith Laursen, RN; Colleen Mackie, RRT; Amy Sanders, PsyD; Gloria Smikle, PNP; Lynn Wineski, NNP. Eunice Kennedy Shriver National Institute of Child Health and Human Development \u2013 Andrew A. Bremer, MD PhD; Rosemary D. Higgins, MD; Stephanie Wilson Archer, MA. Indiana University, Methodist Hospital, and Riley Hospital for Children (UG1 HD27856, UL1 TR6) \u2013 Gregory M. Sokol, MD; Abbey C. Hines, PsyD; Dianne E. Herron, RN CCRC; Donna Watkins, MSN NNP-BC; Susan Gunn, NNP-BC CCRC; Jeff Joyce, CCRC (deceased). McGovern Medical School at The University of Texas Health Science Center at Houston, Children\u2019s Memorial Hermann Hospital, and Memorial Hermann Southwest Hospital (U10 HD21373, UG1 HD87229) \u2013 Jon E. Tyson, MD MPH; Amir M. Khan, MD; Kathleen A. Kennedy, MD MPH; Barbara J. Stoll, MD; Elizabeth Eason, MD; Ricardo A. Mosquera, MD MS; Andrea F. Duncan, MD MS; Nora I. Alaniz, BS; Fatima Boricha, MD; Allison G. Dempsey, PhD; Donna J. Hall, RN; Janice John, CPNP; Karen Martin, RN; Georgia E. McDavid, RN; Shannon L. McKee, EdS; Kimberly Rennie, PhD; Tina Reddy, MD; Debasree Sana Boral, IMG; Daniel K. Sperry, RN; Emily Stephens, BSN RNC-NIC; Sharon L. Wright, MT (ASCP). Nationwide Children\u2019s Hospital, The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Center for Perinatal Research, The Ohio State University College of Medicine, The Ohio State University Wexner Medical Center, and Riverside Methodist Hospital (UG1 HD68278) \u2013 Pablo J. S\u00E1nchez, MD; Leif D. Nelin, MD; Jonathan L. Slaughter, MD MPH; Sudarshan R. Jadcherla, MD; Nathalie L. Maitre, MD PhD; Christopher Timan, MD; Keith O. Yeates, MD PhD; Patricia Luzader, RN; Julie Gutentag, RN BSN; Jennifer L. Grothause, BA RN BSN; Melanie Stein, RRT BBS; Rox Ann Sullivan, RN BSN; Cole D. Hague, BA MS; Helen Carey, PT DHSc PCS; Michelle Chao, BS; Stephanie Burkhardt, BS MPH; Margaret Sullivan, BS; Lina Yossef-Salameh, MD; Mary Ann Nelin, MD; Erna Clark, BA; Julie C. Shadd, BSN RD; Courtney Park, RN BSN; Courtney Cira, BS; Erin Fearns; Kristi Small, BS; Sarah A. Keim, PhD MA MS; Christine A. Fortney, RN PhD; Aubrey Fowler, BS, Jacqueline McCool; Lindsay Pietruszewski, PT DPT; Jessica Purnell, BS CCRC; Kyrstin Warnimont, BS; Laura Marzec, MD; Bethany Miller, RN BSN; Demi R. Beckford, MHS; Hallie Baugher, BS MSN; Julia Newton, MPH; Katelyn Levengood, PT DPT; Nancy Batterson, OT/L; Brittany DeSantis, BS. RTI International (UG1 HD36790) \u2013 Carla M. Bann, PhD; Dennis Wallace, PhD; Marie G. Gantz, PhD; Jeanette O\u2019Donnell Auman, BS; Barry Eggleston, MS; Margaret Crawford, BS; Jenna Gabrio, BS MPH; Jamie E. Newman, PhD MPH; Lindsay Parlberg, BS; Carolyn M. Petrie Huitema, MS; Kristin M. Zaterka-Baxter, RN BSN. Stanford University, El Camino Hospital, and Lucile Packard Children\u2019s Hospital (UG1 HD27880, UL1 TR93) \u2013 Valerie Chock, MD MS Epi; David K. Stevenson, MD; M. Bethany Ball, BS CCRC; Barbara Bentley, PsychD MSEd; Maria Elena DeAnda, PhD; Anne M. DeBattista, RN PNP PhD; Beth Earhart, PhD; Lynne C. Huffman, MD; Casey E. Krueger, PhD; Ryan E. Lucash, PhD; Melinda S. Proud, RCP; Elizabeth N. Reichert, MA CCRC; Heather Taylor, PhD; Hali E. Weiss, MD; R. Jordan Williams, MD. University of Alabama at Birmingham Health System and Children\u2019s Hospital of Alabama (UG1 HD34216) \u2013 Waldemar A. Carlo, MD; Myriam Peralta-Carcelen, MD MPH; Kirstin J. Bailey, PhD; Fred J. Biasini, PhD; Stephanie A. Chopko, PhD; Monica V. Collins, RN BSN MaEd; Shirley S. Cosby, RN BSN; Kristy A. Domnanovich, PhD; Chantel J. Jno-Finn, PT DPT; Morissa Ladinsky, MD; Mary Beth Moses, PT MS PCS; Tara E. McNair, RN BSN; Vivien A. Phillips, RN BSN; Julie Preskitt, MSOT MPH; Richard V. Rector, PhD; Kimberlly Stringer, MD MPH; Sally Whitley, MA OTR-L FAOTA; Sheree York Chapman, PT DPT PCS. University of California - Los Angeles, Mattel Children\u2019s Hospital, Santa Monica Hospital, Los Robles Hospital and Medical Center, and Olive View Medical Center (UG1 HD68270) \u2013 Uday Devaskar, MD; Meena Garg, MD; Isabell B. Purdy, PhD CPNP; Teresa Chanlaw, MPH; Rachel Geller, RN BSN. University of Iowa, Mercy Medical Center, and Sanford Health (UG1 HD53109, UL1 TR442) \u2013 Tarah T. Colaizy, MD MPH; Jane E. Brumbaugh, MD; Heidi M. Harmon, MD MS; Karen J. Johnson, RN BSN; Mendi L. Schmelzel, RN MSN; Jacky R. Walker, RN; Claire A. Goeke, DNP ARNP; Sarah E. Faruqui, RN MSN; Diane L. Eastman, RN CPNP MA; Michelle L. Baack, MD; Laurie A. Hogden, MD; Megan M. Henning, RN; Chelsey Elenkiwich, NNP APRN CNP; Megan Broadbent, RN BSN; Sarah Van Muyden, RN BSN; Dan L. Ellsbury, MD; Tracy L. Tud, RN. University of New Mexico Health Sciences Center (UG1 HD53089, UL1 TR41) \u2013 Kristi L. Watterberg, MD; Janell Fuller, MD; Robin K. Ohls, MD; Conra Backstrom Lacy, RN; Carol Hartenberger, BSN MPH; Sandra Sundquist Beauman, MSN RNC; Mary Ruffner Hanson, RN BSN; Jean R. Lowe, PhD; Elizabeth Kuan, RN BSN. University of Pennsylvania, Hospital of the University of Pennsylvania, Pennsylvania Hospital, and Children\u2019s Hospital of Philadelphia (UG1 HD68244) \u2013 Sara B. DeMauro, MD MSCE; Barbara Schmidt, MD MSc; Haresh Kirpalani, MB MSc; Soraya Abbasi, MD; Aasma S. Chaudhary, BS RRT; Toni Mancini, RN BSN CCRC; Jonathan Snyder, RN BSN, Kristina Ziolkowski, CMA(AAMA) CCRP. University of Rochester Medical Center, Golisano Children\u2019s Hospital, and the University of Buffalo Women\u2019s and Children\u2019s Hospital of Buffalo (UG1 HD68263, UL1 TR42) \u2013 Carl T. D\u2019Angio, MD; Ronnie Guillet, MD PhD; Satyan Lakshminrusimha, MD; Gary J. Myers, MD; Anne Marie Reynolds, MD; Holly I.M. Wadkins; Michael G. Sacilowski, BS; Rosemary L. Jensen; Joan Merzbach, LMSW; William Zorn, PhD; Osman Farooq, MD; Stephanie Guilford, BS; Kelley Yost, PhD; Mary Rowan, RN; Diane Prinzing; Ann Marie Scorsone, MS CCRC; Michelle Hartley-McAndrew, MD; Kyle Binion, BS; Constance Orme; Premini Sabaratnam, MPH; Alison Kent, BMBS FRACP MD; Rachel Jones; Elizabeth Boylin, BA; Daisy Rochez, BS MHA; Emily Li, BA; Jennifer Kachelmeyer, BS; Kimberly G. McKee, BS; Kelly R. Coleman, PsyD; Deanna Maffett, RN. University of Texas Southwestern Medical Center, Parkland Health & Hospital System, and Children\u2019s Medical Center Dallas (UG1 HD40689) \u2013 Luc P. Brion, MD; Roy J. Heyne, MD; Diana M. Vasil, MSN BSN RNC-NIC; Maria M. De Leon, RN BSN; Frances Eubanks, RN BSN; E. Rebecca McDougald, MSN APRN CPNP-PC/AC; Pollieanna Sepulveda, RN; Alicia Guzman; Elizabeth Heyne, PsyD PA-C; Lizette E. Lee, RN; Azucena Vera, AS; Jillian Waterbury, DNP RN CPNP-PC; Cathy Twell Boatman, MS CIMI; Kristine Tolentino-Plata, MS. University of Utah Medical Center, Intermountain Medical Center, McKay-Dee Hospital, Utah Valley Hospital, and Primary Children\u2019s Medical Center (UG1 HD87226, UL1 TR105) \u2013 Bradley A. Yoder, MD; Mariana Baserga, MD MSCI; Roger G. Faix, MD; Sarah Winter, MD; Stephen D. Minton, MD; Mark J. Sheffield, MD; Carrie A. Rau, RN BSN CCRC; Shawna Baker, RN; Jill Burnett, RNC BSN; Susan Christensen, RN; Sean D. Cunningham, PhD; Brandy Davis, RN BSN; Jennifer O. Elmont, RN BSN; Becky Hall, APRN; Erika R. Jensen, APRN; Jamie Jordan, RN BSN; Manndi C. Loertscher, BS CCRP; Trisha Marchant, RNC BSN; Earl Maxson, RN CCRN; Kandace M. McGrath, BS; Hena G. Mickelsen, BA; Galina Morshedzadeh, BSN APRN; D. Melody Parry, RN BSN; Susan T. Schaefer, RN BSN RRT; Kelly Stout, PhD; Ashley L. Stuart, PhD; Katherine Tice, RN BSN; Kimberlee Weaver-Lewis, RN MS; Kathryn D. Woodbury, RN BSN. Wayne State University, Hutzel Women\u2019s Hospital, and Children\u2019s Hospital of Michigan (UG1 HD21385) \u2013 Beena G. Sood, MD MS; Athina Pappas, MD; Monika Bajaj, MD; Melissa February, MD; Prashant Agarwal, MD; Rebecca Bara, RN BSN; Kirsten Childs, RN BSN; Eunice Hinz Woldt, RN MSN; Laura Goldston, MA, John Barks, MD; Stephanie A. Wiggins, MS; Mary K. Christensen, BA RRT; Martha Carlson, MD; Diane F. White, RRT CCRP. The National Institutes of Health and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (U10 HD21373, UG1 HD21364, UG1 HD21385, UG1 HD27851, UG1 HD27853, UG1 HD27856, UG1 HD27880, UG1 HD27904, UG1 HD34216, UG1 HD36790, UG1 HD40492, UG1 HD40689, UG1 HD53089, UG1 HD53109, UG1 HD68244, UG1 HD68270, UG1 HD68278, UG1 HD68263, UG1 HD68284; UG1 HD87226, UG1 HD87229) and the National Center for Advancing Translational Sciences (NCATS) (UL1 TR6, UL1 TR41, UL1 TR42, UL1 TR77, UL1 TR93, UL1 TR105, UL1 TR442, UL1 TR454, UL1 TR1117, provided grant support for the Neonatal Research Network, including for the Follow-up Study. Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA. All authors have indicated they have no financial relationships relevant to this article to disclose.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Obstetrics and Gynecology