Association of monosodium glutamate intake with overweight in Chinese adults: The INTERMAP study

Ka He, Liancheng Zhao, Martha L. Daviglus, Alan R. Dyer, Linda Van Horn, Daniel Garside, Liguang Zhu, Dongshuang Guo, Yangfeng Wu, Beifan Zhou, Jeremiah Stamler*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

99 Scopus citations

Abstract

Animal studies indicate that monosodium glutamate (MSG) can induce hypothalamic lesions and leptin resistance, possibly influencing energy balance, leading to overweight. This study examines the association between MSG intake and overweight in humans. We conducted a cross-sectional study involving 752 healthy Chinese (48.7% women), aged 40-59 years, randomly sampled from three rural villages in north and south China. The great majority of participants prepared their foods at home, without use of commercially processed foods. Diet was assessed with four in-depth multipass 24-h recalls. Participants were asked to demonstrate MSG amounts added in food preparation. Amounts shaken out were weighed by trained interviewers. Overweight was defined as BMI ≥25.0 or ≥23.0 kg/m2(based on World Health Organization recommendations for Asian populations). Eighty-two percent of participants were MSG users. Average intake was 0.33 g/day (s.d. = 0.40). With adjustment for potential confounders including physical activity and total energy intake, MSG intake was positively related to BMI. Prevalence of overweight was significantly higher in MSG users than nonusers. For users in the highest tertile of MSG intake compared to nonusers, the multivariable-adjusted odds ratios of overweight (BMI ≥23.0 and ≥25.0) were 2.10 (95% confidence interval, 1.13-3.90, P for trend across four MSG categories = 0.03) and 2.75 (95% confidence interval, 1.28-5.95, P = 0.04). This research provides data that MSG intake may be associated with increased risk of overweight independent of physical activity and total energy intake in humans.

Original languageEnglish (US)
Pages (from-to)1875-1880
Number of pages6
JournalObesity
Volume16
Issue number8
DOIs
StatePublished - Aug 2008

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Fingerprint

Dive into the research topics of 'Association of monosodium glutamate intake with overweight in Chinese adults: The INTERMAP study'. Together they form a unique fingerprint.

Cite this