Association of p53 codon 72 polymorphism with liver metastases of colorectal cancers positive for p53 overexpression

Zhong zheng Zhu*, Bing Liu, Ai Zhong Wang, Hang Ruo Jia, Xia Xiang Jin, Xiang Lei He, Li Fang Hou, Guan Shan Zhu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Objective: To evaluate the association between p53 codon 72 polymorphism (R72P) and the risk of colorectal liver metastases. Methods: The p53 R72P genotype was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 78 consecutive colorectal cancer patients with liver metastases and 214 age-and sex-matched cases with nonmetastatic colorectal cancer. Results: The R allele of the p53 R72P polymorphism was more frequently found in metastatic cases than in nonmetastatic cases (P=0.075). Carriers of the 72R allele had a 2.25-fold (95% CI (confidence interval)= 1.05∼4.83) increased risk of liver metastases. On the stratification analysis, 72R-carrying genotype conferred a 3.46-fold (95% CI=1.02∼11.72) and a 1.05-fold (95% CI=0.36∼3.08) increased risk of liver metastases for p53 overexpression-positive and negative colorectal cancers, respectively. Conclusion: These results demonstrate for the first time that the 72R allele of the p53 polymorphism has an increased risk for liver metastases in colorectal cancers positive for p53 overexpression.

Original languageEnglish (US)
Pages (from-to)847-852
Number of pages6
JournalJournal of Zhejiang University: Science B
Volume9
Issue number11
DOIs
StatePublished - 2008

Keywords

  • Colorectal cancer
  • Genetic polymorphism
  • Liver metastases
  • Overexpression
  • p53

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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