@article{1108d71713914021af9ecca7222455f1,
title = "Association of Peripheral Lymphocyte Subsets with Cognitive Decline and Dementia: The Cardiovascular Health Study",
abstract = "Inflammatory biomarkers in plasma are associated with dementia. Thus, we examined the association of 18 types of peripheral immune cells, measured as proportions of their immune cell type, with cross-sectional measures of cognitive function, change in cognitive function over seven years, prevalent dementia, and time to death from dementia in 1,928 participants of the Cardiovascular Health Study, with mean age 80 years and 62% female. We did not identify any associations after accounting for multiple comparisons, though we identified marginal associations of peripheral regulatory T cells with cognitive decline and dementia.",
keywords = "Alzheimer's disease, B cells, benton visual retention test, cognitive impairment, immune, natural killer cells",
author = "Fohner, {Alison E.} and Sitlani, {Colleen M.} and Petra Buzkova and Doyle, {Margaret F.} and Xiaojuan Liu and Bis, {Joshua C.} and Annette Fitzpatrick and Heckbert, {Susan R.} and Huber, {Sally A.} and Lewis Kuller and Longstreth, {William T.} and Feinstein, {Matthew J.} and Matthew Freiberg and Olson, {Nels C.} and Sudha Seshadri and Oscar Lopez and Odden, {Michelle C.} and Tracy, {Russell P.} and Psaty, {Bruce M.} and Delaney, {Joseph A.} and Floyd, {James S.}",
note = "Funding Information: The role of the immune system in dementia is likely complex. While neuroinflammation is well This project was supported by grants HL120854 and HL135625 from the National Heart Lung and Blood Institute (NHLBI). The CHS cohort was sup ported by contracts HHSN268201200036C, HHSN 268200800007C, HHSN268201800001C, N01HC 55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086, 75N 92021D00006, and grants U01HL080295 and U01HL130114 from the National Heart, Lung, and Blood Institute (NHLBI), with additional contribution from the National Institute of Neurological Disorders and Stroke (NINDS). Additional support was provided by R01AG023629 from the National Institute on Aging (NIA). Alison Fohner is supported by K01AG071689. A full list of principal CHS investigators and institutions can be found at CHS-NHLBI.org. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2022 IOS Press. All rights reserved.",
year = "2022",
doi = "10.3233/JAD-220091",
language = "English (US)",
volume = "88",
pages = "7--15",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
publisher = "IOS Press",
number = "1",
}
