Association of Peripheral Lymphocyte Subsets with Cognitive Decline and Dementia: The Cardiovascular Health Study

Alison E. Fohner; Colleen M. Sitlani; Petra Buzkova; Margaret F. Doyle; Xiaojuan Liu; Joshua C. Bis; Annette Fitzpatrick; Susan R. Heckbert; Sally A. Huber; Lewis Kuller; William T. Longstreth; Matthew J. Feinstein; Matthew Freiberg; Nels C. Olson; Sudha Seshadri; Oscar Lopez; Michelle C. Odden; Russell P. Tracy; Bruce M. Psaty; Joseph A. Delaney; James S. Floyd

doi:10.3233/JAD-220091

Association of Peripheral Lymphocyte Subsets with Cognitive Decline and Dementia: The Cardiovascular Health Study

Alison E. Fohner^*, Colleen M. Sitlani, Petra Buzkova, Margaret F. Doyle, Xiaojuan Liu, Joshua C. Bis, Annette Fitzpatrick, Susan R. Heckbert, Sally A. Huber, Lewis Kuller, William T. Longstreth, Matthew J. Feinstein, Matthew Freiberg, Nels C. Olson, Sudha Seshadri, Oscar Lopez, Michelle C. Odden, Russell P. Tracy, Bruce M. Psaty, Joseph A. DelaneyJames S. Floyd

^*Corresponding author for this work

Medicine, Cardiology Division

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Inflammatory biomarkers in plasma are associated with dementia. Thus, we examined the association of 18 types of peripheral immune cells, measured as proportions of their immune cell type, with cross-sectional measures of cognitive function, change in cognitive function over seven years, prevalent dementia, and time to death from dementia in 1,928 participants of the Cardiovascular Health Study, with mean age 80 years and 62% female. We did not identify any associations after accounting for multiple comparisons, though we identified marginal associations of peripheral regulatory T cells with cognitive decline and dementia.

Original language	English (US)
Pages (from-to)	7-15
Number of pages	9
Journal	Journal of Alzheimer's Disease
Volume	88
Issue number	1
DOIs	https://doi.org/10.3233/JAD-220091
State	Published - 2022

Funding

The role of the immune system in dementia is likely complex. While neuroinflammation is well This project was supported by grants HL120854 and HL135625 from the National Heart Lung and Blood Institute (NHLBI). The CHS cohort was sup ported by contracts HHSN268201200036C, HHSN 268200800007C, HHSN268201800001C, N01HC 55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086, 75N 92021D00006, and grants U01HL080295 and U01HL130114 from the National Heart, Lung, and Blood Institute (NHLBI), with additional contribution from the National Institute of Neurological Disorders and Stroke (NINDS). Additional support was provided by R01AG023629 from the National Institute on Aging (NIA). Alison Fohner is supported by K01AG071689. A full list of principal CHS investigators and institutions can be found at CHS-NHLBI.org. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Keywords

Alzheimer's disease
B cells
benton visual retention test
cognitive impairment
immune
natural killer cells

ASJC Scopus subject areas

General Neuroscience
Clinical Psychology
Geriatrics and Gerontology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3233/JAD-220091

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Fohner, A. E., Sitlani, C. M., Buzkova, P., Doyle, M. F., Liu, X., Bis, J. C., Fitzpatrick, A., Heckbert, S. R., Huber, S. A., Kuller, L., Longstreth, W. T., Feinstein, M. J., Freiberg, M., Olson, N. C., Seshadri, S., Lopez, O., Odden, M. C., Tracy, R. P., Psaty, B. M., ... Floyd, J. S. (2022). Association of Peripheral Lymphocyte Subsets with Cognitive Decline and Dementia: The Cardiovascular Health Study. Journal of Alzheimer's Disease, 88(1), 7-15. https://doi.org/10.3233/JAD-220091

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abstract = "Inflammatory biomarkers in plasma are associated with dementia. Thus, we examined the association of 18 types of peripheral immune cells, measured as proportions of their immune cell type, with cross-sectional measures of cognitive function, change in cognitive function over seven years, prevalent dementia, and time to death from dementia in 1,928 participants of the Cardiovascular Health Study, with mean age 80 years and 62% female. We did not identify any associations after accounting for multiple comparisons, though we identified marginal associations of peripheral regulatory T cells with cognitive decline and dementia.",

keywords = "Alzheimer's disease, B cells, benton visual retention test, cognitive impairment, immune, natural killer cells",

author = "Fohner, {Alison E.} and Sitlani, {Colleen M.} and Petra Buzkova and Doyle, {Margaret F.} and Xiaojuan Liu and Bis, {Joshua C.} and Annette Fitzpatrick and Heckbert, {Susan R.} and Huber, {Sally A.} and Lewis Kuller and Longstreth, {William T.} and Feinstein, {Matthew J.} and Matthew Freiberg and Olson, {Nels C.} and Sudha Seshadri and Oscar Lopez and Odden, {Michelle C.} and Tracy, {Russell P.} and Psaty, {Bruce M.} and Delaney, {Joseph A.} and Floyd, {James S.}",

year = "2022",

doi = "10.3233/JAD-220091",

language = "English (US)",

volume = "88",

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Fohner, AE, Sitlani, CM, Buzkova, P, Doyle, MF, Liu, X, Bis, JC, Fitzpatrick, A, Heckbert, SR, Huber, SA, Kuller, L, Longstreth, WT, Feinstein, MJ, Freiberg, M, Olson, NC, Seshadri, S, Lopez, O, Odden, MC, Tracy, RP, Psaty, BM, Delaney, JA & Floyd, JS 2022, 'Association of Peripheral Lymphocyte Subsets with Cognitive Decline and Dementia: The Cardiovascular Health Study', Journal of Alzheimer's Disease, vol. 88, no. 1, pp. 7-15. https://doi.org/10.3233/JAD-220091

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T1 - Association of Peripheral Lymphocyte Subsets with Cognitive Decline and Dementia

T2 - The Cardiovascular Health Study

AU - Fohner, Alison E.

AU - Sitlani, Colleen M.

AU - Buzkova, Petra

AU - Doyle, Margaret F.

AU - Liu, Xiaojuan

AU - Bis, Joshua C.

AU - Fitzpatrick, Annette

AU - Heckbert, Susan R.

AU - Huber, Sally A.

AU - Kuller, Lewis

AU - Longstreth, William T.

AU - Feinstein, Matthew J.

AU - Freiberg, Matthew

AU - Olson, Nels C.

AU - Seshadri, Sudha

AU - Lopez, Oscar

AU - Odden, Michelle C.

AU - Tracy, Russell P.

AU - Psaty, Bruce M.

AU - Delaney, Joseph A.

AU - Floyd, James S.

PY - 2022

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AB - Inflammatory biomarkers in plasma are associated with dementia. Thus, we examined the association of 18 types of peripheral immune cells, measured as proportions of their immune cell type, with cross-sectional measures of cognitive function, change in cognitive function over seven years, prevalent dementia, and time to death from dementia in 1,928 participants of the Cardiovascular Health Study, with mean age 80 years and 62% female. We did not identify any associations after accounting for multiple comparisons, though we identified marginal associations of peripheral regulatory T cells with cognitive decline and dementia.

KW - Alzheimer's disease

KW - B cells

KW - benton visual retention test

KW - cognitive impairment

KW - immune

KW - natural killer cells

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Association of Peripheral Lymphocyte Subsets with Cognitive Decline and Dementia: The Cardiovascular Health Study

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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