Association of PTSD With Longitudinal COVID-19 Burden in a Mixed-Serostatus Cohort of Men and Women: Weathering the Storm

Deborah L. Jones; Yuehan Zhang; Violeta J. Rodriguez; Sabina Haberlen; Catalina Ramirez; Adaora A. Adimora; Daniel Merenstein; Bradley Aouizerat; Anjali Sharma; Tracey Wilson; Matthew J. Mimiaga; Anandi N. Sheth; Michael Plankey; Mardge H. Cohen; Valentina Stosor; Mirjam Colette Kempf; M. Reuel Friedman

doi:10.1097/QAI.0000000000003006

Association of PTSD With Longitudinal COVID-19 Burden in a Mixed-Serostatus Cohort of Men and Women: Weathering the Storm

Deborah L. Jones^*, Yuehan Zhang, Violeta J. Rodriguez, Sabina Haberlen, Catalina Ramirez, Adaora A. Adimora, Daniel Merenstein, Bradley Aouizerat, Anjali Sharma, Tracey Wilson, Matthew J. Mimiaga, Anandi N. Sheth, Michael Plankey, Mardge H. Cohen, Valentina Stosor, Mirjam Colette Kempf, M. Reuel Friedman

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives:This study of people with HIV (PWH) and those without HIV conducted during the COVID-19 pandemic in the United States in 2020 examines the impact of posttraumatic stress disorder (PTSD) on COVID-19 burden, defined as pandemic-related disruptions.Methods:Data consisted of survey responses on PTSD among participants (N = 2434) enrolled in the Multicenter AIDS Cohort Study (MACS) and the Women's Interagency HIV (WIHS) cohorts. Unadjusted and adjusted regression models were used to examine the association of PTSD with COVID-19 burden (overall and domain-specific burdens). Quasi-Poisson regression models were used to assess associations with the COVID-19 burden score and 2 domain-specific burdens: (1) changes in resources and (2) interruptions in health care. Analyses was adjusted for age, race/ethnicity, HIV serostatus, current smoking status, number of comorbidities, education, and study regions.Results:Study participants were a median age of 58 (interquartile range, 52-65) years. In both bivariate and multivariable models, PTSD severity was associated with greater overall COVID-19 burden. PTSD severity was associated with the number of resource changes and number of interruptions in medical care. These findings were also consistent across cohorts (MACS/WIHS) and across HIV serostatus, suggesting a greater risk for COVID-19 burden with greater PTSD severity, which remained significant after controlling for covariates.Conclusions:This study builds on emerging literature demonstrating the impact of mental health on the burden and disruption associated with the COVID-19 pandemic, providing context specific to PWH. The ongoing pandemic requires structural and social interventions to decrease disruption to resources and health resource needs among these vulnerable populations.

Original language	English (US)
Pages (from-to)	567-575
Number of pages	9
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	90
Issue number	5
DOIs	https://doi.org/10.1097/QAI.0000000000003006
State	Published - Aug 15 2022

Funding

Data in this manuscript were collected by the MACS/WIHS Combined Cohort Study (MWCCS). The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH). MWCCS (Principal Investigators): Atlanta CRS (Ighovwerha Ofotokun, Anandi Sheth, and Gina Wingood), U01-HL146241; Baltimore CRS (Todd Brown and Joseph Margolick), U01-HL146201; Bronx CRS (Kathryn Anastos and Anjali Sharma), U01-HL146204; Brooklyn CRS (Deborah Gustafson and Tracey Wilson), U01-HL146202; Data Analysis and Coordination Center (Gypsyamber D'Souza, Stephen Gange and Elizabeth Golub), U01-HL146193; Chicago-Cook County CRS (Mardge Cohen and Audrey French), U01-HL146245; Chicago-Northwestern CRS (Steven Wolinsky), U01-HL146240; Northern California CRS (Bradley Aouizerat, Jennifer Price, and Phyllis Tien), U01-HL146242; Los Angeles CRS (Roger Detels and Matthew Mimiaga), U01-HL146333; Metropolitan Washington CRS (Seble Kassaye and Daniel Merenstein), U01-HL146205; Miami CRS (Maria Alcaide, Margaret Fischl, and Deborah Jones), U01-HL146203; Pittsburgh CRS (Jeremy Martinson and Charles Rinaldo), U01-HL146208; UAB-MS CRS (Mirjam-Colette Kempf, Jodie Dionne-Odom, and Deborah Konkle-Parker), U01-HL146192; and UNC CRS (Adaora Adimora), U01-HL146194. The MWCCS is funded primarily by the National Heart, Lung, and Blood Institute (NHLBI), with additional cofunding from the Eunice Kennedy Shriver National Institute Of Child Health and Human Development (NICHD), National Institute On Aging (NIA), National Institute Of Dental and Craniofacial Research (NIDCR), National Institute Of Allergy and Infectious Diseases (NIAID), National Institute Of Neurological Disorders and Stroke (NINDS), National Institute Of Mental Health (NIMH), National Institute On Drug Abuse (NIDA), National Institute Of Nursing Research (NINR), National Cancer Institute (NCI), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute on Minority Health and Health Disparities (NIMHD), and in coordination and alignment with the research priorities of the National Institutes of Health, Office of AIDS Research (OAR). MWCCS data collection is also supported by UL1-TR000004 (UCSF CTSA), UL1-TR003098 (JHU ICTR), UL1-TR001881 (UCLA CTSI), P30-AI-050409 (Atlanta CFAR), P30-AI-073961 (Miami CFAR), P30-AI-050410 (UNC CFAR), P30-AI-027767 (UAB CFAR), and P30-MH-116867 (Miami CHARM). VJR's work on this study was partially supported by a Ford Foundation Fellowship, administered by the National Academies of Science, a PEO Scholar Award from the PEO Sisterhood, and a grant from the National Institute of Mental Health of the National Institutes of Health under Award Number R36MH127838.

Keywords

COVID-19
HIV
MACS
WIHS
posttraumatic stress disorder

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/QAI.0000000000003006

Cite this

Jones, D. L., Zhang, Y., Rodriguez, V. J., Haberlen, S., Ramirez, C., Adimora, A. A., Merenstein, D., Aouizerat, B., Sharma, A., Wilson, T., Mimiaga, M. J., Sheth, A. N., Plankey, M., Cohen, M. H., Stosor, V., Kempf, M. C., & Friedman, M. R. (2022). Association of PTSD With Longitudinal COVID-19 Burden in a Mixed-Serostatus Cohort of Men and Women: Weathering the Storm. Journal of Acquired Immune Deficiency Syndromes, 90(5), 567-575. https://doi.org/10.1097/QAI.0000000000003006

@article{f0211039d45c4277865db33207bac9aa,

title = "Association of PTSD With Longitudinal COVID-19 Burden in a Mixed-Serostatus Cohort of Men and Women: Weathering the Storm",

abstract = "Objectives:This study of people with HIV (PWH) and those without HIV conducted during the COVID-19 pandemic in the United States in 2020 examines the impact of posttraumatic stress disorder (PTSD) on COVID-19 burden, defined as pandemic-related disruptions.Methods:Data consisted of survey responses on PTSD among participants (N = 2434) enrolled in the Multicenter AIDS Cohort Study (MACS) and the Women's Interagency HIV (WIHS) cohorts. Unadjusted and adjusted regression models were used to examine the association of PTSD with COVID-19 burden (overall and domain-specific burdens). Quasi-Poisson regression models were used to assess associations with the COVID-19 burden score and 2 domain-specific burdens: (1) changes in resources and (2) interruptions in health care. Analyses was adjusted for age, race/ethnicity, HIV serostatus, current smoking status, number of comorbidities, education, and study regions.Results:Study participants were a median age of 58 (interquartile range, 52-65) years. In both bivariate and multivariable models, PTSD severity was associated with greater overall COVID-19 burden. PTSD severity was associated with the number of resource changes and number of interruptions in medical care. These findings were also consistent across cohorts (MACS/WIHS) and across HIV serostatus, suggesting a greater risk for COVID-19 burden with greater PTSD severity, which remained significant after controlling for covariates.Conclusions:This study builds on emerging literature demonstrating the impact of mental health on the burden and disruption associated with the COVID-19 pandemic, providing context specific to PWH. The ongoing pandemic requires structural and social interventions to decrease disruption to resources and health resource needs among these vulnerable populations.",

keywords = "COVID-19, HIV, MACS, WIHS, posttraumatic stress disorder",

author = "Jones, {Deborah L.} and Yuehan Zhang and Rodriguez, {Violeta J.} and Sabina Haberlen and Catalina Ramirez and Adimora, {Adaora A.} and Daniel Merenstein and Bradley Aouizerat and Anjali Sharma and Tracey Wilson and Mimiaga, {Matthew J.} and Sheth, {Anandi N.} and Michael Plankey and Cohen, {Mardge H.} and Valentina Stosor and Kempf, {Mirjam Colette} and Friedman, {M. Reuel}",

year = "2022",

month = aug,

day = "15",

doi = "10.1097/QAI.0000000000003006",

language = "English (US)",

volume = "90",

pages = "567--575",

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Jones, DL, Zhang, Y, Rodriguez, VJ, Haberlen, S, Ramirez, C, Adimora, AA, Merenstein, D, Aouizerat, B, Sharma, A, Wilson, T, Mimiaga, MJ, Sheth, AN, Plankey, M, Cohen, MH, Stosor, V, Kempf, MC & Friedman, MR 2022, 'Association of PTSD With Longitudinal COVID-19 Burden in a Mixed-Serostatus Cohort of Men and Women: Weathering the Storm', Journal of Acquired Immune Deficiency Syndromes, vol. 90, no. 5, pp. 567-575. https://doi.org/10.1097/QAI.0000000000003006

TY - JOUR

T1 - Association of PTSD With Longitudinal COVID-19 Burden in a Mixed-Serostatus Cohort of Men and Women

T2 - Weathering the Storm

AU - Jones, Deborah L.

AU - Zhang, Yuehan

AU - Rodriguez, Violeta J.

AU - Haberlen, Sabina

AU - Ramirez, Catalina

AU - Adimora, Adaora A.

AU - Merenstein, Daniel

AU - Aouizerat, Bradley

AU - Sharma, Anjali

AU - Wilson, Tracey

AU - Mimiaga, Matthew J.

AU - Sheth, Anandi N.

AU - Plankey, Michael

AU - Cohen, Mardge H.

AU - Stosor, Valentina

AU - Kempf, Mirjam Colette

AU - Friedman, M. Reuel

PY - 2022/8/15

Y1 - 2022/8/15

N2 - Objectives:This study of people with HIV (PWH) and those without HIV conducted during the COVID-19 pandemic in the United States in 2020 examines the impact of posttraumatic stress disorder (PTSD) on COVID-19 burden, defined as pandemic-related disruptions.Methods:Data consisted of survey responses on PTSD among participants (N = 2434) enrolled in the Multicenter AIDS Cohort Study (MACS) and the Women's Interagency HIV (WIHS) cohorts. Unadjusted and adjusted regression models were used to examine the association of PTSD with COVID-19 burden (overall and domain-specific burdens). Quasi-Poisson regression models were used to assess associations with the COVID-19 burden score and 2 domain-specific burdens: (1) changes in resources and (2) interruptions in health care. Analyses was adjusted for age, race/ethnicity, HIV serostatus, current smoking status, number of comorbidities, education, and study regions.Results:Study participants were a median age of 58 (interquartile range, 52-65) years. In both bivariate and multivariable models, PTSD severity was associated with greater overall COVID-19 burden. PTSD severity was associated with the number of resource changes and number of interruptions in medical care. These findings were also consistent across cohorts (MACS/WIHS) and across HIV serostatus, suggesting a greater risk for COVID-19 burden with greater PTSD severity, which remained significant after controlling for covariates.Conclusions:This study builds on emerging literature demonstrating the impact of mental health on the burden and disruption associated with the COVID-19 pandemic, providing context specific to PWH. The ongoing pandemic requires structural and social interventions to decrease disruption to resources and health resource needs among these vulnerable populations.

AB - Objectives:This study of people with HIV (PWH) and those without HIV conducted during the COVID-19 pandemic in the United States in 2020 examines the impact of posttraumatic stress disorder (PTSD) on COVID-19 burden, defined as pandemic-related disruptions.Methods:Data consisted of survey responses on PTSD among participants (N = 2434) enrolled in the Multicenter AIDS Cohort Study (MACS) and the Women's Interagency HIV (WIHS) cohorts. Unadjusted and adjusted regression models were used to examine the association of PTSD with COVID-19 burden (overall and domain-specific burdens). Quasi-Poisson regression models were used to assess associations with the COVID-19 burden score and 2 domain-specific burdens: (1) changes in resources and (2) interruptions in health care. Analyses was adjusted for age, race/ethnicity, HIV serostatus, current smoking status, number of comorbidities, education, and study regions.Results:Study participants were a median age of 58 (interquartile range, 52-65) years. In both bivariate and multivariable models, PTSD severity was associated with greater overall COVID-19 burden. PTSD severity was associated with the number of resource changes and number of interruptions in medical care. These findings were also consistent across cohorts (MACS/WIHS) and across HIV serostatus, suggesting a greater risk for COVID-19 burden with greater PTSD severity, which remained significant after controlling for covariates.Conclusions:This study builds on emerging literature demonstrating the impact of mental health on the burden and disruption associated with the COVID-19 pandemic, providing context specific to PWH. The ongoing pandemic requires structural and social interventions to decrease disruption to resources and health resource needs among these vulnerable populations.

KW - COVID-19

KW - HIV

KW - MACS

KW - WIHS

KW - posttraumatic stress disorder

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Association of PTSD With Longitudinal COVID-19 Burden in a Mixed-Serostatus Cohort of Men and Women: Weathering the Storm

Abstract

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UN SDGs

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