Association of systemic inflammation, adiposity, and metabolic dysregulation with asthma burden among Hispanic adults

Deepa Rastogi*, Molly Jung, Garrett Strizich, Pamela A. Shaw, Sonia M. Davis, Oana L. Klein, Frank J. Penedo, Andrew L. Ries, Martha L. Daviglus, Juan J. Moreiras, Matthias A. Salathe, Juan C. Celedón, Carmen R. Isasi, Robert C. Kaplan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Rationale Obesity-related asthma is associated with higher disease burden than normal-weight asthma among Hispanics. Adiposity, metabolic dysregulation, and inflammation are all implicated in pathogenesis of obesity-related asthma, but their independent contributions are poorly understood. Objective To examine the independent contributions of body fat distribution, metabolic abnormalities and inflammation on asthma symptoms and pulmonary function among Hispanics. Methods Participants of the Hispanic Community Health Study/Study of Latinos with doctor-diagnosed asthma who completed an asthma symptom questionnaire and performed a valid spirometry were included in the analysis (n = 1126). Multivariate analysis was used to examine the independent association of general adiposity (assessed using body mass index), truncal adiposity (assessed by waist circumference), metabolic dysregulation (presence of insulin resistance and low HDL) and inflammation (high-sensitivity C-Reactive Protein≥3 mg/L) with reported asthma symptoms or pulmonary function measures (FEV1, and FVC) while adjusting for demographic and clinical covariates. Results Of the 1126 participants, 334 (29.5%) were overweight, and 648 (57.8%) were obese. FEV1 and FVC were lower in obese compared to normal-weight asthmatics. In analyses controlling for metabolic and adiposity factors, high hs-CRP (>7 mg/L) was associated with more symptoms (prevalence-ratio 1.27 (95%CI 1.05, 1.54), and lower FVC (β −138 ml (95%CI -27 ml, −249 ml)) and FEV1 (β −155 ml (95% CI -38 ml, −272 ml). Low HDL was also associated with lower FVC (β −111 ml (−22 ml, −201 ml) and FEV1 (β −100 ml (−12 ml, −188 ml)). Results were similar in men and women. Conclusions Our findings suggest that hs-CRP and low HDL, rather than general and truncal adiposity, are associated with asthma burden among overweight and obese Hispanic adults.

Original languageEnglish (US)
Pages (from-to)72-81
Number of pages10
JournalRespiratory Medicine
Volume125
DOIs
StatePublished - Apr 1 2017

Funding

The Hispanic Community Health Study/Study of Latinos was carried out as a collaborative study supported by contracts from the National Heart, Lung, and Blood Institute to the University of North Carolina (N01-HC65233), University of Miami (N01- HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following institutes, centers, or offices contribute to the HCHS/SOL through a transfer of funds to the NHLBI: National Center on Minority Health and Health Disparities, the National Institute on Deafness and Other Communications Disorders, the National Institute of Dental and Craniofacial Research, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Neurological Disorders and Stroke, and the Office of Dietary Supplements. Dr. Deepa Rastogi is supported by K23 HL118733.

Keywords

  • Asthma
  • Hispanics
  • Inflammation
  • Obesity
  • Pulmonary function

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Fingerprint

Dive into the research topics of 'Association of systemic inflammation, adiposity, and metabolic dysregulation with asthma burden among Hispanic adults'. Together they form a unique fingerprint.

Cite this