Association of the degree of adiposity and duration of obesity with measures of cardiac structure and function: The CARDIA study

Jared P. Reis*, Norrina Allen, Bethany B. Gibbs, Samuel S. Gidding, Joyce M. Lee, Cora E. Lewis, Joao Lima, Donald Lloyd-Jones, Catherine M. Loria, Tiffany M. Powell-Wiley, Shishir Sharma, Gina Wei, Kiang Liu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Objective: Examine whether there are independent influences of a greater degree of adiposity and longer duration of obesity on cardiac structure and function. Methods: Participants of CARDIA were 18-30 years when they underwent a baseline examination in 1985-86. Seven follow-up examinations were conducted every 2-5 years. Results: Among 2,547 participants who underwent an echocardiogram at the year 25 examination and were not obese at baseline, 34.4 and 35.5% were overall (BMI ≥ 30 kg m-2) and abdominally obese (waist circumference: men: >102 cm; women: >88 cm) at year 25, respectively. A greater degree of overall and abdominal adiposity at year 25 were each associated with a greater left ventricular (LV) mass (P < 0.001), LV volume (P < 0.001), LV mass-to-volume ratio (P < 0.001), left atrial dimension (P < 0.001), and ejection fraction (P < 0.05) after adjustment for duration of obesity and other risk factors. In contrast, a longer duration of overall obesity was associated with a greater LV mass (P = 0.003) and a trend for a lower ejection fraction (P = 0.07). Conclusions: A greater degree of adiposity is strongly associated with concentric LV remodeling in midlife, while the cumulative effects of a longer duration of overall obesity during young adulthood contribute to concentric remodeling predominantly by increasing LV mass.

Original languageEnglish (US)
Pages (from-to)2434-2440
Number of pages7
Issue number11
StatePublished - Nov 1 2014

ASJC Scopus subject areas

  • Endocrinology
  • Nutrition and Dietetics
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism


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