Association of the orphan nuclear receptor NR4A1 with tardive dyskinesia

Gabriela Novak; Alexandra Gallo; Clement C. Zai; Herbert Y. Meltzer; Jeffrey A. Lieberman; Steven G. Potkin; Aristotle N. Voineskos; Gary Remington; James L. Kennedy; Daniel Levesque; Bernard Le Foll

doi:10.1097/YPG.0b013e3283351221

Association of the orphan nuclear receptor NR4A1 with tardive dyskinesia

Gabriela Novak, Alexandra Gallo, Clement C. Zai, Herbert Y. Meltzer, Jeffrey A. Lieberman, Steven G. Potkin, Aristotle N. Voineskos, Gary Remington, James L. Kennedy, Daniel Levesque, Bernard Le Foll

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Recent evidence has identified the NR4A1 (NUR77, NGFI-B) gene as a strong candidate for involvement in tardive dyskinesia (TD). We have investigated the association of six single nucleotide polymorphisms within the NR4A family of genes with TD in a sample of 171 patients with schizophrenia of Caucasian descent. The NR4A1 single nucleotide polymorphism (SNP) marker rs2603751 showed a nominal association with the risk of TD, as well as with the extent of TD based on the Abnormal Involuntary Movements Scale (AIMS) scores. The haplotype generated by the markers rs2603751 and rs2701124 also showed association with TD and, after adjustment for multiple testing, both the NR4A1 marker rs2603751 and the haplotype continued to show a trend toward association with TD. Although the results of this study are limited by a small sample size, it presents important pilot data and warrants further investigation of the involvement of NR4A1 variants in TD.

Original language	English (US)
Pages (from-to)	39-43
Number of pages	5
Journal	Psychiatric Genetics
Volume	20
Issue number	1
DOIs	https://doi.org/10.1097/YPG.0b013e3283351221
State	Published - Feb 2010

Keywords

Antipsychotic
GFRP1
Genetic
NAK1
NGFI-B
NR4A
NUR77,polymorphism
Schizophrenia
Tardive dyskinesia

ASJC Scopus subject areas

Genetics
Genetics(clinical)
Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/YPG.0b013e3283351221

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title = "Association of the orphan nuclear receptor NR4A1 with tardive dyskinesia",

abstract = "Recent evidence has identified the NR4A1 (NUR77, NGFI-B) gene as a strong candidate for involvement in tardive dyskinesia (TD). We have investigated the association of six single nucleotide polymorphisms within the NR4A family of genes with TD in a sample of 171 patients with schizophrenia of Caucasian descent. The NR4A1 single nucleotide polymorphism (SNP) marker rs2603751 showed a nominal association with the risk of TD, as well as with the extent of TD based on the Abnormal Involuntary Movements Scale (AIMS) scores. The haplotype generated by the markers rs2603751 and rs2701124 also showed association with TD and, after adjustment for multiple testing, both the NR4A1 marker rs2603751 and the haplotype continued to show a trend toward association with TD. Although the results of this study are limited by a small sample size, it presents important pilot data and warrants further investigation of the involvement of NR4A1 variants in TD.",

keywords = "Antipsychotic, GFRP1, Genetic, NAK1, NGFI-B, NR4A, NUR77,polymorphism, Schizophrenia, Tardive dyskinesia",

author = "Gabriela Novak and Alexandra Gallo and Zai, {Clement C.} and Meltzer, {Herbert Y.} and Lieberman, {Jeffrey A.} and Potkin, {Steven G.} and Voineskos, {Aristotle N.} and Gary Remington and Kennedy, {James L.} and Daniel Levesque and {Le Foll}, Bernard",

year = "2010",

month = feb,

doi = "10.1097/YPG.0b013e3283351221",

language = "English (US)",

volume = "20",

pages = "39--43",

journal = "Psychiatric Genetics",

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AU - Novak, Gabriela

AU - Gallo, Alexandra

AU - Zai, Clement C.

AU - Meltzer, Herbert Y.

AU - Lieberman, Jeffrey A.

AU - Potkin, Steven G.

AU - Voineskos, Aristotle N.

AU - Remington, Gary

AU - Kennedy, James L.

AU - Levesque, Daniel

AU - Le Foll, Bernard

PY - 2010/2

Y1 - 2010/2

N2 - Recent evidence has identified the NR4A1 (NUR77, NGFI-B) gene as a strong candidate for involvement in tardive dyskinesia (TD). We have investigated the association of six single nucleotide polymorphisms within the NR4A family of genes with TD in a sample of 171 patients with schizophrenia of Caucasian descent. The NR4A1 single nucleotide polymorphism (SNP) marker rs2603751 showed a nominal association with the risk of TD, as well as with the extent of TD based on the Abnormal Involuntary Movements Scale (AIMS) scores. The haplotype generated by the markers rs2603751 and rs2701124 also showed association with TD and, after adjustment for multiple testing, both the NR4A1 marker rs2603751 and the haplotype continued to show a trend toward association with TD. Although the results of this study are limited by a small sample size, it presents important pilot data and warrants further investigation of the involvement of NR4A1 variants in TD.

AB - Recent evidence has identified the NR4A1 (NUR77, NGFI-B) gene as a strong candidate for involvement in tardive dyskinesia (TD). We have investigated the association of six single nucleotide polymorphisms within the NR4A family of genes with TD in a sample of 171 patients with schizophrenia of Caucasian descent. The NR4A1 single nucleotide polymorphism (SNP) marker rs2603751 showed a nominal association with the risk of TD, as well as with the extent of TD based on the Abnormal Involuntary Movements Scale (AIMS) scores. The haplotype generated by the markers rs2603751 and rs2701124 also showed association with TD and, after adjustment for multiple testing, both the NR4A1 marker rs2603751 and the haplotype continued to show a trend toward association with TD. Although the results of this study are limited by a small sample size, it presents important pilot data and warrants further investigation of the involvement of NR4A1 variants in TD.

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KW - NGFI-B

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KW - Schizophrenia

KW - Tardive dyskinesia

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Association of the orphan nuclear receptor NR4A1 with tardive dyskinesia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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