Association of the TP53 codon 72 polymorphism with colorectal cancer in a Chinese population

Zhong Zheng Zhu*, Ai Zhong Wang, Hang Ruo Jia, Xia Xiang Jin, Xiang Lei He, Li Fang Hou, Guanshan Zhu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

A TP53 gene polymorphism, resulting in an arginine (R) to proline (P) at codon 72 (TP53 R72P), has been associated with the susceptibility to various cancers. To better understand the role of this polymorphism in colorectal cancer etiology, we examined the association between TP53 R72P and colorectal cancer risk in 345 patients with colorectal cancer and 670 controls in a Chinese population. We observed that subjects with RP and PP genotypes had a 1.60-fold and a 2.37-fold increased risk for colorectal cancer, respectively. The 72P allele conferred a more pronounced increase in colorectal cancer risk among alcohol consumers (heterozygotes: OR = 3.01; homozygotes: OR = 4.71). The TP53 R72P polymorphism was not linked to tumor location, histologic grade, lymph node metastases, Dukes stage, p53 positivity, or age at diagnosis, but to tumor size. We conclude that the TP53 R72P polymorphism may contribute to the etiology of colorectal cancer in the Chinese population, particularly among alcohol consumers.

Original languageEnglish (US)
Pages (from-to)385-390
Number of pages6
JournalJapanese Journal of Clinical Oncology
Volume37
Issue number5
DOIs
StatePublished - May 2007

Keywords

  • Colorectal cancer
  • Single nucleotide polymorphism
  • TP53

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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