Association of transforming growth factor-beta 1 polymorphisms with genetic susceptibility to TNM stage I or II gastric cancer

Pin Zhang, Jian Zhong Di, Zhong Zheng Zhu, Hui Min Wu, Yu Wang*, Guanshan Zhu, Qi Zheng, Lifang Hou

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Transforming growth factor-beta 1 (TGF-β1) inhibits the proliferation of tumors in early stages of cancers, whereas it promotes tumor growth and metastasis in later stages of cancers. To examine the effect of the TGF-β1 polymorphisms on gastric cancer risk, we studied the association between C-509T and T+29C (Leu10Pro) polymorphisms in TGF-β1 and gastric cancer risk in 414 cases and 414 controls in the Chinese population. When the overall gastric cancer cases were compared with the controls, no significant difference was found in genotype distributions for both the polymorphisms examined. However, when stratified by tumor stage, the -509T and +29C allele carriers had a 0.57-fold (95% CI = 0.36-0.90) and a 0.58-fold (95% CI = 0.36-0.91) decreased risk of TNM stage I+II gastric cancer, respectively, as compared with non-carriers. We conclude that TGF-β1-509T and +29C alleles may have a protective role in the development of stage I+II gastric cancer.

Original languageEnglish (US)
Pages (from-to)861-866
Number of pages6
JournalJapanese Journal of Clinical Oncology
Volume38
Issue number12
DOIs
StatePublished - 2008

Keywords

  • Gastric cancer
  • Genetic susceptibility
  • Single nucleotide polymorphism
  • TGF-β1

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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