Association of transforming growth factor-beta 1 polymorphisms with genetic susceptibility to TNM stage I or II gastric cancer

Pin Zhang; Jian Zhong Di; Zhong Zheng Zhu; Hui Min Wu; Yu Wang; Guanshan Zhu; Qi Zheng; Lifang Hou

doi:10.1093/jjco/hyn111

Association of transforming growth factor-beta 1 polymorphisms with genetic susceptibility to TNM stage I or II gastric cancer

Pin Zhang, Jian Zhong Di, Zhong Zheng Zhu, Hui Min Wu, Yu Wang^*, Guanshan Zhu, Qi Zheng, Lifang Hou

^*Corresponding author for this work

Preventive Medicine

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Transforming growth factor-beta 1 (TGF-β1) inhibits the proliferation of tumors in early stages of cancers, whereas it promotes tumor growth and metastasis in later stages of cancers. To examine the effect of the TGF-β1 polymorphisms on gastric cancer risk, we studied the association between C-509T and T+29C (Leu10Pro) polymorphisms in TGF-β1 and gastric cancer risk in 414 cases and 414 controls in the Chinese population. When the overall gastric cancer cases were compared with the controls, no significant difference was found in genotype distributions for both the polymorphisms examined. However, when stratified by tumor stage, the -509T and +29C allele carriers had a 0.57-fold (95% CI = 0.36-0.90) and a 0.58-fold (95% CI = 0.36-0.91) decreased risk of TNM stage I+II gastric cancer, respectively, as compared with non-carriers. We conclude that TGF-β1-509T and +29C alleles may have a protective role in the development of stage I+II gastric cancer.

Original language	English (US)
Pages (from-to)	861-866
Number of pages	6
Journal	Japanese Journal of Clinical Oncology
Volume	38
Issue number	12
DOIs	https://doi.org/10.1093/jjco/hyn111
State	Published - 2008

Keywords

Gastric cancer
Genetic susceptibility
Single nucleotide polymorphism
TGF-β1

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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title = "Association of transforming growth factor-beta 1 polymorphisms with genetic susceptibility to TNM stage I or II gastric cancer",

abstract = "Transforming growth factor-beta 1 (TGF-β1) inhibits the proliferation of tumors in early stages of cancers, whereas it promotes tumor growth and metastasis in later stages of cancers. To examine the effect of the TGF-β1 polymorphisms on gastric cancer risk, we studied the association between C-509T and T+29C (Leu10Pro) polymorphisms in TGF-β1 and gastric cancer risk in 414 cases and 414 controls in the Chinese population. When the overall gastric cancer cases were compared with the controls, no significant difference was found in genotype distributions for both the polymorphisms examined. However, when stratified by tumor stage, the -509T and +29C allele carriers had a 0.57-fold (95% CI = 0.36-0.90) and a 0.58-fold (95% CI = 0.36-0.91) decreased risk of TNM stage I+II gastric cancer, respectively, as compared with non-carriers. We conclude that TGF-β1-509T and +29C alleles may have a protective role in the development of stage I+II gastric cancer.",

keywords = "Gastric cancer, Genetic susceptibility, Single nucleotide polymorphism, TGF-β1",

author = "Pin Zhang and Di, {Jian Zhong} and Zhu, {Zhong Zheng} and Wu, {Hui Min} and Yu Wang and Guanshan Zhu and Qi Zheng and Lifang Hou",

note = "Funding Information: This work was supported by a grant (No. 06MA27) from Medical Science and Technology Research Foundation for the 11th 5-Year Program of PLA, Nanjing branch, P.R. China.",

year = "2008",

doi = "10.1093/jjco/hyn111",

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T1 - Association of transforming growth factor-beta 1 polymorphisms with genetic susceptibility to TNM stage I or II gastric cancer

AU - Zhang, Pin

AU - Di, Jian Zhong

AU - Zhu, Zhong Zheng

AU - Wu, Hui Min

AU - Wang, Yu

AU - Zhu, Guanshan

AU - Zheng, Qi

AU - Hou, Lifang

N1 - Funding Information: This work was supported by a grant (No. 06MA27) from Medical Science and Technology Research Foundation for the 11th 5-Year Program of PLA, Nanjing branch, P.R. China.

PY - 2008

Y1 - 2008

N2 - Transforming growth factor-beta 1 (TGF-β1) inhibits the proliferation of tumors in early stages of cancers, whereas it promotes tumor growth and metastasis in later stages of cancers. To examine the effect of the TGF-β1 polymorphisms on gastric cancer risk, we studied the association between C-509T and T+29C (Leu10Pro) polymorphisms in TGF-β1 and gastric cancer risk in 414 cases and 414 controls in the Chinese population. When the overall gastric cancer cases were compared with the controls, no significant difference was found in genotype distributions for both the polymorphisms examined. However, when stratified by tumor stage, the -509T and +29C allele carriers had a 0.57-fold (95% CI = 0.36-0.90) and a 0.58-fold (95% CI = 0.36-0.91) decreased risk of TNM stage I+II gastric cancer, respectively, as compared with non-carriers. We conclude that TGF-β1-509T and +29C alleles may have a protective role in the development of stage I+II gastric cancer.

AB - Transforming growth factor-beta 1 (TGF-β1) inhibits the proliferation of tumors in early stages of cancers, whereas it promotes tumor growth and metastasis in later stages of cancers. To examine the effect of the TGF-β1 polymorphisms on gastric cancer risk, we studied the association between C-509T and T+29C (Leu10Pro) polymorphisms in TGF-β1 and gastric cancer risk in 414 cases and 414 controls in the Chinese population. When the overall gastric cancer cases were compared with the controls, no significant difference was found in genotype distributions for both the polymorphisms examined. However, when stratified by tumor stage, the -509T and +29C allele carriers had a 0.57-fold (95% CI = 0.36-0.90) and a 0.58-fold (95% CI = 0.36-0.91) decreased risk of TNM stage I+II gastric cancer, respectively, as compared with non-carriers. We conclude that TGF-β1-509T and +29C alleles may have a protective role in the development of stage I+II gastric cancer.

KW - Gastric cancer

KW - Genetic susceptibility

KW - Single nucleotide polymorphism

KW - TGF-β1

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Association of transforming growth factor-beta 1 polymorphisms with genetic susceptibility to TNM stage I or II gastric cancer

Abstract

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