Association of virologic failure and nonnucleoside reverse transcriptase inhibitor resistance found in antiretroviral-naive children infected with human immunodeficiency virus and given efavirenz-based treatment

Nikki Higa; Amy Pelz; Donald Birch; Ingrid A. Beck; Tatiana Sils; Pearl Samson; Mutsawashe Bwakura-Dangarembizi; Carolyn Bolton-Moore; Edmund Capparelli; Ellen Chadwick; Lisa M. Frenkel

doi:10.1093/JPIDS/PIZ038

Association of virologic failure and nonnucleoside reverse transcriptase inhibitor resistance found in antiretroviral-naive children infected with human immunodeficiency virus and given efavirenz-based treatment

Nikki Higa, Amy Pelz, Donald Birch, Ingrid A. Beck, Tatiana Sils, Pearl Samson, Mutsawashe Bwakura-Dangarembizi, Carolyn Bolton-Moore, Edmund Capparelli, Ellen Chadwick, Lisa M. Frenkel^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Among 66 antiretroviral-naive children aged <3 years with human immunodeficiency virus (HIV) or coinfected with HIV and tuberculosis and initiating efavirenz-based antiretroviral therapy (ART), non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance was detected before ART in 5 (7.6%). Virologic failure occurred in 2 of these children; they were last tested at 16 and 24 weeks of ART. Pre-ART NNRTI resistance was not associated with virologic failure.

Original language	English (US)
Pages (from-to)	261-264
Number of pages	4
Journal	Journal of the Pediatric Infectious Diseases Society
Volume	9
Issue number	2
DOIs	https://doi.org/10.1093/JPIDS/PIZ038
State	Published - 2020

Keywords

Efavirenz
HIV drug resistance
HIV-infected children
HIV/TB coinfection
NNRTI resistance

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/JPIDS/PIZ038

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Higa, N., Pelz, A., Birch, D., Beck, I. A., Sils, T., Samson, P., Bwakura-Dangarembizi, M., Bolton-Moore, C., Capparelli, E., Chadwick, E., & Frenkel, L. M. (2020). Association of virologic failure and nonnucleoside reverse transcriptase inhibitor resistance found in antiretroviral-naive children infected with human immunodeficiency virus and given efavirenz-based treatment. Journal of the Pediatric Infectious Diseases Society, 9(2), 261-264. https://doi.org/10.1093/JPIDS/PIZ038

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title = "Association of virologic failure and nonnucleoside reverse transcriptase inhibitor resistance found in antiretroviral-naive children infected with human immunodeficiency virus and given efavirenz-based treatment",

abstract = "Among 66 antiretroviral-naive children aged <3 years with human immunodeficiency virus (HIV) or coinfected with HIV and tuberculosis and initiating efavirenz-based antiretroviral therapy (ART), non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance was detected before ART in 5 (7.6%). Virologic failure occurred in 2 of these children; they were last tested at 16 and 24 weeks of ART. Pre-ART NNRTI resistance was not associated with virologic failure.",

keywords = "Efavirenz, HIV drug resistance, HIV-infected children, HIV/TB coinfection, NNRTI resistance",

author = "Nikki Higa and Amy Pelz and Donald Birch and Beck, {Ingrid A.} and Tatiana Sils and Pearl Samson and Mutsawashe Bwakura-Dangarembizi and Carolyn Bolton-Moore and Edmund Capparelli and Ellen Chadwick and Frenkel, {Lisa M.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2019.",

year = "2020",

doi = "10.1093/JPIDS/PIZ038",

language = "English (US)",

volume = "9",

pages = "261--264",

journal = "Journal of the Pediatric Infectious Diseases Society",

issn = "2048-7207",

publisher = "Oxford University Press",

number = "2",

}

Higa, N, Pelz, A, Birch, D, Beck, IA, Sils, T, Samson, P, Bwakura-Dangarembizi, M, Bolton-Moore, C, Capparelli, E, Chadwick, E & Frenkel, LM 2020, 'Association of virologic failure and nonnucleoside reverse transcriptase inhibitor resistance found in antiretroviral-naive children infected with human immunodeficiency virus and given efavirenz-based treatment', Journal of the Pediatric Infectious Diseases Society, vol. 9, no. 2, pp. 261-264. https://doi.org/10.1093/JPIDS/PIZ038

Association of virologic failure and nonnucleoside reverse transcriptase inhibitor resistance found in antiretroviral-naive children infected with human immunodeficiency virus and given efavirenz-based treatment. / Higa, Nikki; Pelz, Amy; Birch, Donald et al.

In: Journal of the Pediatric Infectious Diseases Society, Vol. 9, No. 2, 2020, p. 261-264.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Association of virologic failure and nonnucleoside reverse transcriptase inhibitor resistance found in antiretroviral-naive children infected with human immunodeficiency virus and given efavirenz-based treatment

AU - Higa, Nikki

AU - Pelz, Amy

AU - Birch, Donald

AU - Beck, Ingrid A.

AU - Sils, Tatiana

AU - Samson, Pearl

AU - Bwakura-Dangarembizi, Mutsawashe

AU - Bolton-Moore, Carolyn

AU - Capparelli, Edmund

AU - Chadwick, Ellen

AU - Frenkel, Lisa M.

PY - 2020

Y1 - 2020

N2 - Among 66 antiretroviral-naive children aged <3 years with human immunodeficiency virus (HIV) or coinfected with HIV and tuberculosis and initiating efavirenz-based antiretroviral therapy (ART), non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance was detected before ART in 5 (7.6%). Virologic failure occurred in 2 of these children; they were last tested at 16 and 24 weeks of ART. Pre-ART NNRTI resistance was not associated with virologic failure.

AB - Among 66 antiretroviral-naive children aged <3 years with human immunodeficiency virus (HIV) or coinfected with HIV and tuberculosis and initiating efavirenz-based antiretroviral therapy (ART), non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance was detected before ART in 5 (7.6%). Virologic failure occurred in 2 of these children; they were last tested at 16 and 24 weeks of ART. Pre-ART NNRTI resistance was not associated with virologic failure.

KW - Efavirenz

KW - HIV drug resistance

KW - HIV-infected children

KW - HIV/TB coinfection

KW - NNRTI resistance

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U2 - 10.1093/JPIDS/PIZ038

DO - 10.1093/JPIDS/PIZ038

M3 - Article

C2 - 31194860

AN - SCOPUS:85084191655

SN - 2048-7207

VL - 9

SP - 261

EP - 264

JO - Journal of the Pediatric Infectious Diseases Society

JF - Journal of the Pediatric Infectious Diseases Society

IS - 2

ER -

Association of virologic failure and nonnucleoside reverse transcriptase inhibitor resistance found in antiretroviral-naive children infected with human immunodeficiency virus and given efavirenz-based treatment

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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