Association of Virologic Failure and Nonnucleoside Reverse Transcriptase Inhibitor Resistance Found in Antiretroviral-Naive Children Infected With Human Immunodeficiency Virus and Given Efavirenz-Based Treatment

Nikki Higa, Amy Pelz, Donald Birch, Ingrid A. Beck, Tatiana Sils, Pearl Samson, Mutsawashe Bwakura-Dangarembizi, Carolyn Bolton-Moore, Edmund Capparelli, Ellen Chadwick, Lisa M. Frenkel

Research output: Contribution to journalArticle

Abstract

Among 66 antiretroviral-naive children aged <3 years with human immunodeficiency virus (HIV) or coinfected with HIV and tuberculosis and initiating efavirenz-based antiretroviral therapy (ART), non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance was detected before ART in 5 (7.6%). Virologic failure occurred in 2 of these children; they were last tested at 16 and 24 weeks of ART. Pre-ART NNRTI resistance was not associated with virologic failure.

Original languageEnglish (US)
Pages (from-to)261-264
Number of pages4
JournalJournal of the Pediatric Infectious Diseases Society
Volume9
Issue number2
DOIs
StatePublished - Apr 30 2020

Keywords

  • HIV drug resistance
  • HIV-infected children
  • HIV/TB coinfection
  • NNRTI resistance
  • efavirenz

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases

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