Association study between the neurexin-1 gene and tardive dyskinesia

Rachel Lanning; Tristram A. Lett; Arun K. Tiwari; Eva J. Brandl; Vincenzo de Luca; Aristotle N. Voineskos; Steven G. Potkin; Jeffrey A. Lieberman; Herbert Y. Meltzer; Daniel J. Müller; Gary Remington; James L. Kennedy; Clement C. Zai

doi:10.1002/hup.2568

Association study between the neurexin-1 gene and tardive dyskinesia

Rachel Lanning, Tristram A. Lett, Arun K. Tiwari, Eva J. Brandl, Vincenzo de Luca, Aristotle N. Voineskos, Steven G. Potkin, Jeffrey A. Lieberman, Herbert Y. Meltzer, Daniel J. Müller, Gary Remington, James L. Kennedy^*, Clement C. Zai

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Objective: Tardive dyskinesia (TD) is a motor side effect that may develop after long-term antipsychotic treatment. Schizophrenia has recently been associated with the Neurexin-1 (NRXN1) gene that codes for a cell adhesion molecule in synaptic communication. Methods: This study examined five NRXN1 single-nucleotide polymorphisms (SNPs) for possible association with the occurrence and severity of TD in 178 schizophrenia patients of European ancestry. Results: We did not find these SNPs to be significantly associated with TD. Conclusions: More research is needed with additional SNPs and in bigger samples before we can completely rule out the role of NRXN1 in TD.

Original language	English (US)
Article number	e2568
Journal	Human Psychopharmacology
Volume	32
Issue number	1
DOIs	https://doi.org/10.1002/hup.2568
State	Published - Jan 1 2017

Keywords

antipsychotics
neurexin-1 (NRXN1)
pharmacogenetic
schizophrenia (SCZ)
tardive dyskinesia (TD)

ASJC Scopus subject areas

Clinical Neurology
Neurology
Psychiatry and Mental health
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hup.2568

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title = "Association study between the neurexin-1 gene and tardive dyskinesia",

abstract = "Objective: Tardive dyskinesia (TD) is a motor side effect that may develop after long-term antipsychotic treatment. Schizophrenia has recently been associated with the Neurexin-1 (NRXN1) gene that codes for a cell adhesion molecule in synaptic communication. Methods: This study examined five NRXN1 single-nucleotide polymorphisms (SNPs) for possible association with the occurrence and severity of TD in 178 schizophrenia patients of European ancestry. Results: We did not find these SNPs to be significantly associated with TD. Conclusions: More research is needed with additional SNPs and in bigger samples before we can completely rule out the role of NRXN1 in TD.",

keywords = "antipsychotics, neurexin-1 (NRXN1), pharmacogenetic, schizophrenia (SCZ), tardive dyskinesia (TD)",

author = "Rachel Lanning and Lett, {Tristram A.} and Tiwari, {Arun K.} and Brandl, {Eva J.} and {de Luca}, Vincenzo and Voineskos, {Aristotle N.} and Potkin, {Steven G.} and Lieberman, {Jeffrey A.} and Meltzer, {Herbert Y.} and M{\"u}ller, {Daniel J.} and Gary Remington and Kennedy, {James L.} and Zai, {Clement C.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2017 John Wiley & Sons, Ltd.",

year = "2017",

month = jan,

day = "1",

doi = "10.1002/hup.2568",

language = "English (US)",

volume = "32",

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T1 - Association study between the neurexin-1 gene and tardive dyskinesia

AU - Lanning, Rachel

AU - Lett, Tristram A.

AU - Tiwari, Arun K.

AU - Brandl, Eva J.

AU - de Luca, Vincenzo

AU - Voineskos, Aristotle N.

AU - Potkin, Steven G.

AU - Lieberman, Jeffrey A.

AU - Meltzer, Herbert Y.

AU - Müller, Daniel J.

AU - Remington, Gary

AU - Kennedy, James L.

AU - Zai, Clement C.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Objective: Tardive dyskinesia (TD) is a motor side effect that may develop after long-term antipsychotic treatment. Schizophrenia has recently been associated with the Neurexin-1 (NRXN1) gene that codes for a cell adhesion molecule in synaptic communication. Methods: This study examined five NRXN1 single-nucleotide polymorphisms (SNPs) for possible association with the occurrence and severity of TD in 178 schizophrenia patients of European ancestry. Results: We did not find these SNPs to be significantly associated with TD. Conclusions: More research is needed with additional SNPs and in bigger samples before we can completely rule out the role of NRXN1 in TD.

AB - Objective: Tardive dyskinesia (TD) is a motor side effect that may develop after long-term antipsychotic treatment. Schizophrenia has recently been associated with the Neurexin-1 (NRXN1) gene that codes for a cell adhesion molecule in synaptic communication. Methods: This study examined five NRXN1 single-nucleotide polymorphisms (SNPs) for possible association with the occurrence and severity of TD in 178 schizophrenia patients of European ancestry. Results: We did not find these SNPs to be significantly associated with TD. Conclusions: More research is needed with additional SNPs and in bigger samples before we can completely rule out the role of NRXN1 in TD.

KW - antipsychotics

KW - neurexin-1 (NRXN1)

KW - pharmacogenetic

KW - schizophrenia (SCZ)

KW - tardive dyskinesia (TD)

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Association study between the neurexin-1 gene and tardive dyskinesia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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