Association study of the gamma-aminobutyric acid type a receptor γ2 subunit gene with schizophrenia

Clement C. Zai; Arun K. Tiwari; Nicole King; Vincenzo De Luca; Daniel J. Mueller; Sajid Shaikh; Greg W H Wong; Herbert Y. Meltzer; Jeffrey A. Lieberman; James L. Kennedy

doi:10.1016/j.schres.2009.07.010

Association study of the gamma-aminobutyric acid type a receptor γ2 subunit gene with schizophrenia

Clement C. Zai, Arun K. Tiwari, Nicole King, Vincenzo De Luca, Daniel J. Mueller, Sajid Shaikh, Greg W H Wong, Herbert Y. Meltzer, Jeffrey A. Lieberman, James L. Kennedy^*

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Schizophrenia (SCZ) is a severe neuropsychiatric disorder with a strong genetic basis. We analyzed eight GABRG2 and one DRD5 tag single-nucleotide polymorphisms for association with SCZ in 109 small nuclear families and 229 independent SCZ case-control pairs. The marker rs183294 in the 5′ region of GABRG2 was found to be associated with SCZ in both samples with the C allele over-represented in SCZ cases and over-transmitted in SCZ families (combined z = 9.18; p < 1 × 10^{- 3}). Taken together, the results of the present study suggest that GABRG2 may be involved in SCZ susceptibility, but further studies are required.

Original language	English (US)
Pages (from-to)	33-38
Number of pages	6
Journal	Schizophrenia Research
Volume	114
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2009.07.010
State	Published - Oct 2009

Keywords

Dopamine receptor gene DRD5
Family based association test
GABAA gamma2 subunit gene GABRG2
Genetics
Haplotype analysis
Paired case-control sample
Schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.schres.2009.07.010

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@article{8cbb581a28e34540bbf43b663d773e1d,

title = "Association study of the gamma-aminobutyric acid type a receptor γ2 subunit gene with schizophrenia",

abstract = "Schizophrenia (SCZ) is a severe neuropsychiatric disorder with a strong genetic basis. We analyzed eight GABRG2 and one DRD5 tag single-nucleotide polymorphisms for association with SCZ in 109 small nuclear families and 229 independent SCZ case-control pairs. The marker rs183294 in the 5′ region of GABRG2 was found to be associated with SCZ in both samples with the C allele over-represented in SCZ cases and over-transmitted in SCZ families (combined z = 9.18; p < 1 × 10- 3). Taken together, the results of the present study suggest that GABRG2 may be involved in SCZ susceptibility, but further studies are required.",

keywords = "Dopamine receptor gene DRD5, Family based association test, GABAA gamma2 subunit gene GABRG2, Genetics, Haplotype analysis, Paired case-control sample, Schizophrenia",

author = "Zai, {Clement C.} and Tiwari, {Arun K.} and Nicole King and {De Luca}, Vincenzo and Mueller, {Daniel J.} and Sajid Shaikh and Wong, {Greg W H} and Meltzer, {Herbert Y.} and Lieberman, {Jeffrey A.} and Kennedy, {James L.}",

year = "2009",

month = oct,

doi = "10.1016/j.schres.2009.07.010",

language = "English (US)",

volume = "114",

pages = "33--38",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier",

number = "1-3",

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TY - JOUR

T1 - Association study of the gamma-aminobutyric acid type a receptor γ2 subunit gene with schizophrenia

AU - Zai, Clement C.

AU - Tiwari, Arun K.

AU - King, Nicole

AU - De Luca, Vincenzo

AU - Mueller, Daniel J.

AU - Shaikh, Sajid

AU - Wong, Greg W H

AU - Meltzer, Herbert Y.

AU - Lieberman, Jeffrey A.

AU - Kennedy, James L.

PY - 2009/10

Y1 - 2009/10

N2 - Schizophrenia (SCZ) is a severe neuropsychiatric disorder with a strong genetic basis. We analyzed eight GABRG2 and one DRD5 tag single-nucleotide polymorphisms for association with SCZ in 109 small nuclear families and 229 independent SCZ case-control pairs. The marker rs183294 in the 5′ region of GABRG2 was found to be associated with SCZ in both samples with the C allele over-represented in SCZ cases and over-transmitted in SCZ families (combined z = 9.18; p < 1 × 10- 3). Taken together, the results of the present study suggest that GABRG2 may be involved in SCZ susceptibility, but further studies are required.

AB - Schizophrenia (SCZ) is a severe neuropsychiatric disorder with a strong genetic basis. We analyzed eight GABRG2 and one DRD5 tag single-nucleotide polymorphisms for association with SCZ in 109 small nuclear families and 229 independent SCZ case-control pairs. The marker rs183294 in the 5′ region of GABRG2 was found to be associated with SCZ in both samples with the C allele over-represented in SCZ cases and over-transmitted in SCZ families (combined z = 9.18; p < 1 × 10- 3). Taken together, the results of the present study suggest that GABRG2 may be involved in SCZ susceptibility, but further studies are required.

KW - Dopamine receptor gene DRD5

KW - Family based association test

KW - GABAA gamma2 subunit gene GABRG2

KW - Genetics

KW - Haplotype analysis

KW - Paired case-control sample

KW - Schizophrenia

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UR - http://www.scopus.com/inward/citedby.url?scp=69849108231&partnerID=8YFLogxK

U2 - 10.1016/j.schres.2009.07.010

DO - 10.1016/j.schres.2009.07.010

M3 - Article

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AN - SCOPUS:69849108231

SN - 0920-9964

VL - 114

SP - 33

EP - 38

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1-3

ER -

Association study of the gamma-aminobutyric acid type a receptor γ2 subunit gene with schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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