Association study of the gamma-aminobutyric acid type a receptor γ2 subunit gene with schizophrenia

Clement C. Zai, Arun K. Tiwari, Nicole King, Vincenzo De Luca, Daniel J. Mueller, Sajid Shaikh, Greg W H Wong, Herbert Y. Meltzer, Jeffrey A. Lieberman, James L. Kennedy*

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Schizophrenia (SCZ) is a severe neuropsychiatric disorder with a strong genetic basis. We analyzed eight GABRG2 and one DRD5 tag single-nucleotide polymorphisms for association with SCZ in 109 small nuclear families and 229 independent SCZ case-control pairs. The marker rs183294 in the 5′ region of GABRG2 was found to be associated with SCZ in both samples with the C allele over-represented in SCZ cases and over-transmitted in SCZ families (combined z = 9.18; p < 1 × 10- 3). Taken together, the results of the present study suggest that GABRG2 may be involved in SCZ susceptibility, but further studies are required.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalSchizophrenia Research
Volume114
Issue number1-3
DOIs
StatePublished - Oct 1 2009

Keywords

  • Dopamine receptor gene DRD5
  • Family based association test
  • GABAA gamma2 subunit gene GABRG2
  • Genetics
  • Haplotype analysis
  • Paired case-control sample
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Zai, C. C., Tiwari, A. K., King, N., De Luca, V., Mueller, D. J., Shaikh, S., Wong, G. W. H., Meltzer, H. Y., Lieberman, J. A., & Kennedy, J. L. (2009). Association study of the gamma-aminobutyric acid type a receptor γ2 subunit gene with schizophrenia. Schizophrenia Research, 114(1-3), 33-38. https://doi.org/10.1016/j.schres.2009.07.010