Association study of Toll-like Receptor 5 (TLR5) and Toll-like Receptor 9 (TLR9) polymorphisms in systemic lupus erythematosus

F. Yesim K. Demirci, Susan Manzi, Rosalind Ramsey-Goldman, Margaret Kenney, Penny S. Shaw, Charmayne M. Dunlop-Thomas, Amy H. Kao, Elisa Y. Rhew, Franklin Bontempo, Candace Kammerer, M. Ilyas Kamboh*

*Corresponding author for this work

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Objective. Toll-like receptors (TLR) play an important role in both adaptive and innate immunity. Variations in TLR genes have been shown to be associated with various infectious and inflammatory diseases. We investigated the association of TLR5 (Arg392Stop, rs5744168) and TLR9 (-1237T→C, rs5743836) single nucleotide polymorphisms (SNP) with systemic lupus erythematosus (SLE) in Caucasian American subjects. Methods. We performed a case-control association study and genotyped 409 Caucasian women with SLE and 509 Caucasian healthy female controls using TaqMan® allelic discrimination (rs5744168) or polymerase chain reaction-restriction fragment length polymorphism analysis (rs5743836). Results. None of the 2 TLR SNP showed a statistically significant association with SLE risk in our cohort. Conclusion. Our results do not indicate a major influence of these putative functional TLR SNP on the susceptibility to (or protection from) SLE.

Original languageEnglish (US)
Pages (from-to)1708-1711
Number of pages4
JournalJournal of Rheumatology
Volume34
Issue number8
StatePublished - Aug 1 2007

Keywords

  • Systemic lupus erythematosus
  • TLR5
  • TLR9
  • Toll-like receptor lupus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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    Demirci, F. Y. K., Manzi, S., Ramsey-Goldman, R., Kenney, M., Shaw, P. S., Dunlop-Thomas, C. M., Kao, A. H., Rhew, E. Y., Bontempo, F., Kammerer, C., & Kamboh, M. I. (2007). Association study of Toll-like Receptor 5 (TLR5) and Toll-like Receptor 9 (TLR9) polymorphisms in systemic lupus erythematosus. Journal of Rheumatology, 34(8), 1708-1711.