Abstract
Background: It is unclear if associations between a parental history of premature CVD (pCVD) and subclinical atherosclerosis are attenuated by adjustment for long-term risk factor levels through middle adulthood. Design: Prospective community-based cohort study. Methods: CARDIA participants who attended the year-20 exam (n=2283, mean age 45 years) were grouped by pCVD status: maternal only, paternal only, any parental, and no parental history (referent).We used separate logistic regression models, adjusted for average risk factor levels over a 20-year follow up to assess associations of parental pCVD and subclinical atherosclerosis in offspring. Results: White participants with any parental history of pCVD had a higher odds of coronary artery calcium (CAC) >0 than participants with no parental history (OR 1.55, 95% CI 1.01-2.37). This was largely driven by the association of a paternal history of pCVD with CAC >0 (OR 2.15, 95% CI 1.42-3.23), which was minimally attenuated by multivariable adjustment (OR 2.09, 95% CI 1.31-3.32). Similarly, adjusted associations between parental pCVD and intima-media thickness (IMT) >90% were observed in white participants with a paternal history of pCVD (OR 1.93, 95% CI 1.10-3.39) and any parental history pCVD (OR 1.67, 95% CI 1.02-2.74). No significant associations between a parental history of pCVD and the odds of subclinical atherosclerosis were observed in black participants. Conclusions: Parental pCVD is independently associated with early development of subclinical atherosclerosis; these associations may be race-specific for participants in their fifth decade of life.
Original language | English (US) |
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Pages (from-to) | 601-607 |
Number of pages | 7 |
Journal | European journal of preventive cardiology |
Volume | 21 |
Issue number | 5 |
DOIs | |
State | Published - May 2014 |
Funding
This work was supported by contracts to Coordinating Center, University of Alabama at Birmingham (N01-HC-95095), Field Center, University of Alabama at Birmingham (N01-HC-48047), Field Center and Diet Reading Center (year-20 exam), University of Minnesota (N01-HC-48048), Field Center, Northwestern University (N01-HC-48049) Kaiser Foundation Research Institute (N01-HC-48050) Echocardiography Reading Center (Years 5 and 10), University of California, Irvine (N01-HC-45134), Computed Tomography Reading Center (year-15 exam), Harbor-UCLA Research Education Institute (N01-HC-05187), Wake Forest University (year-20 exam) (N01-HC-45205), New England Medical Center (year-20 exam) (N01-HC-45204), from the National Heart, Lung, and Blood Institute.
Keywords
- Carotid intima-media thickness
- coronary artery calcium
- family history of premature cardiovascular disease
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Epidemiology