Associations between alcohol and cigarette use and type 1 and 2 myocardial infarction among people with HIV

Lydia N. Drumright; Robin M. Nance; Stephanie A. Ruderman; Jimmy Ma; Bridget M. Whitney; Andrew Hahn; Rob J. Fredericksen; Brandon Luu; William B. Lober; Richard D. Moore; Matthew J. Budoff; Jeanne C. Keruly; Katerina Christopoulos; Sarah Puryear; Amanda Willig; Karen Cropsey; William C. Mathews; Edward Cachay; Laura Bamford; Joseph J. Eron; Sonia Napravnik; Kenneth H. Mayer; Conall O'Cleirigh; Mary E. Mccaul; Geetanjali Chander; Matthew J. Feinstein; Michael S. Saag; Mari M. Kitahata; Susan R. Heckbert; Heidi M. Crane; Joseph A.C. Delaney

doi:10.1111/hiv.13466

Associations between alcohol and cigarette use and type 1 and 2 myocardial infarction among people with HIV

Lydia N. Drumright^*, Robin M. Nance, Stephanie A. Ruderman, Jimmy Ma, Bridget M. Whitney, Andrew Hahn, Rob J. Fredericksen, Brandon Luu, William B. Lober, Richard D. Moore, Matthew J. Budoff, Jeanne C. Keruly, Katerina Christopoulos, Sarah Puryear, Amanda Willig, Karen Cropsey, William C. Mathews, Edward Cachay, Laura Bamford, Joseph J. EronSonia Napravnik, Kenneth H. Mayer, Conall O'Cleirigh, Mary E. Mccaul, Geetanjali Chander, Matthew J. Feinstein, Michael S. Saag, Mari M. Kitahata, Susan R. Heckbert, Heidi M. Crane, Joseph A.C. Delaney

^*Corresponding author for this work

Medicine, Cardiology Division

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Objectives: People with HIV have a higher risk of myocardial infarction (MI) than the general population, with a greater proportion of type 2 MI (T2MI) due to oxygen demand–supply mismatch compared with type 1 (T1MI) resulting from atherothrombotic plaque disruption. People living with HIV report a greater prevalence of cigarette and alcohol use than do the general population. Alcohol use and smoking as risk factors for MI by type are not well studied among people living with HIV. We examined longitudinal associations between smoking and alcohol use patterns and MI by type among people living with HIV. Design and Methods: Using longitudinal data from the Centers for AIDS Research Network of Integrated Clinical Systems cohort, we conducted time-updated Cox proportional hazards models to determine the impact of smoking and alcohol consumption on adjudicated T1MI and T2MI. Results: Among 13 506 people living with HIV, with a median 4 years of follow-up, we observed 177 T1MI and 141 T2MI. Current smoking was associated with a 60% increase in risk of both T1MI and T2MI. In addition, every cigarette smoked per day was associated with a 4% increase in risk of T1MI, with a suggestive, but not significant, 2% increase for T2MI. Cigarette use had a greater impact on T1MI for men than for women and on T2MI for women than for men. Increasing alcohol use was associated with a lower risk of T1MI but not T2MI. Frequency of heavy episodic alcohol use was not associated with MI. Conclusions: Our findings reinforce the prioritization of smoking reduction, even without cessation, and cessation among people living with HIV for MI prevention and highlight the different impacts on MI type by gender.

Original language	English (US)
Pages (from-to)	703-715
Number of pages	13
Journal	HIV Medicine
Volume	24
Issue number	6
DOIs	https://doi.org/10.1111/hiv.13466
State	Published - Jun 2023

Funding

National Institutes of Health; National Heart, Lung, and Blood Institute (NHLBI), Grant/Award Number: R01 HL126538; National Institute of Alcohol Abuse and Alcoholism (NIAAA), Grant/Award Numbers: U01AA020802, U01AA020793, U24AA020801; National Institute of Allergy and Infectious Diseases (NIAID), Grant/Award Numbers: P30 AI094189, P30 AI050410, P30 AI027767, P30 AI027757, R24 AI067039; National Institute on Drug Abuse (NIDA), Grant/Award Numbers: R01DA044112, R01DA047045; National Institute on Aging (NIA), Grant/Award Number: R33AG067069 Funding information This study was funded by the National Heart, Lung, and Blood Institute (NHLBI) [R01 HL126538]; the National Institute of Alcohol Abuse and Alcoholism (NIAAA) [U24AA020801, U01AA020793, and U01AA020802], the National Institute of Allergy and Infectious Diseases (NIAID) [CNICS R24 AI067039; UW CFAR NIAID grant P30 AI027757; UAB CFAR grant P30 AI027767; UNC CFAR grant P30 AI050410; and JHU CFAR grant P30 AI094189], the National Institute on Drug Abuse (NIDA) [R01DA047045 and R01DA044112], and the National Institute on Aging (NIA) [R33AG067069].

Keywords

HIV
alcohol use
binge drinking
people with HIV
smoking
type 1 myocardial infarction
type 2 myocardial infarction

ASJC Scopus subject areas

Health Policy
Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/hiv.13466

Cite this

Drumright, L. N., Nance, R. M., Ruderman, S. A., Ma, J., Whitney, B. M., Hahn, A., Fredericksen, R. J., Luu, B., Lober, W. B., Moore, R. D., Budoff, M. J., Keruly, J. C., Christopoulos, K., Puryear, S., Willig, A., Cropsey, K., Mathews, W. C., Cachay, E., Bamford, L., ... Delaney, J. A. C. (2023). Associations between alcohol and cigarette use and type 1 and 2 myocardial infarction among people with HIV. HIV Medicine, 24(6), 703-715. https://doi.org/10.1111/hiv.13466

@article{75000bec374d4a3792d06473160a1a91,

title = "Associations between alcohol and cigarette use and type 1 and 2 myocardial infarction among people with HIV",

abstract = "Objectives: People with HIV have a higher risk of myocardial infarction (MI) than the general population, with a greater proportion of type 2 MI (T2MI) due to oxygen demand–supply mismatch compared with type 1 (T1MI) resulting from atherothrombotic plaque disruption. People living with HIV report a greater prevalence of cigarette and alcohol use than do the general population. Alcohol use and smoking as risk factors for MI by type are not well studied among people living with HIV. We examined longitudinal associations between smoking and alcohol use patterns and MI by type among people living with HIV. Design and Methods: Using longitudinal data from the Centers for AIDS Research Network of Integrated Clinical Systems cohort, we conducted time-updated Cox proportional hazards models to determine the impact of smoking and alcohol consumption on adjudicated T1MI and T2MI. Results: Among 13 506 people living with HIV, with a median 4 years of follow-up, we observed 177 T1MI and 141 T2MI. Current smoking was associated with a 60% increase in risk of both T1MI and T2MI. In addition, every cigarette smoked per day was associated with a 4% increase in risk of T1MI, with a suggestive, but not significant, 2% increase for T2MI. Cigarette use had a greater impact on T1MI for men than for women and on T2MI for women than for men. Increasing alcohol use was associated with a lower risk of T1MI but not T2MI. Frequency of heavy episodic alcohol use was not associated with MI. Conclusions: Our findings reinforce the prioritization of smoking reduction, even without cessation, and cessation among people living with HIV for MI prevention and highlight the different impacts on MI type by gender.",

keywords = "HIV, alcohol use, binge drinking, people with HIV, smoking, type 1 myocardial infarction, type 2 myocardial infarction",

author = "Drumright, {Lydia N.} and Nance, {Robin M.} and Ruderman, {Stephanie A.} and Jimmy Ma and Whitney, {Bridget M.} and Andrew Hahn and Fredericksen, {Rob J.} and Brandon Luu and Lober, {William B.} and Moore, {Richard D.} and Budoff, {Matthew J.} and Keruly, {Jeanne C.} and Katerina Christopoulos and Sarah Puryear and Amanda Willig and Karen Cropsey and Mathews, {William C.} and Edward Cachay and Laura Bamford and Eron, {Joseph J.} and Sonia Napravnik and Mayer, {Kenneth H.} and Conall O'Cleirigh and Mccaul, {Mary E.} and Geetanjali Chander and Feinstein, {Matthew J.} and Saag, {Michael S.} and Kitahata, {Mari M.} and Heckbert, {Susan R.} and Crane, {Heidi M.} and Delaney, {Joseph A.C.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association.",

year = "2023",

month = jun,

doi = "10.1111/hiv.13466",

language = "English (US)",

volume = "24",

pages = "703--715",

journal = "HIV Medicine",

issn = "1464-2662",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "6",

}

Drumright, LN, Nance, RM, Ruderman, SA, Ma, J, Whitney, BM, Hahn, A, Fredericksen, RJ, Luu, B, Lober, WB, Moore, RD, Budoff, MJ, Keruly, JC, Christopoulos, K, Puryear, S, Willig, A, Cropsey, K, Mathews, WC, Cachay, E, Bamford, L, Eron, JJ, Napravnik, S, Mayer, KH, O'Cleirigh, C, Mccaul, ME, Chander, G, Feinstein, MJ, Saag, MS, Kitahata, MM, Heckbert, SR, Crane, HM & Delaney, JAC 2023, 'Associations between alcohol and cigarette use and type 1 and 2 myocardial infarction among people with HIV', HIV Medicine, vol. 24, no. 6, pp. 703-715. https://doi.org/10.1111/hiv.13466

TY - JOUR

T1 - Associations between alcohol and cigarette use and type 1 and 2 myocardial infarction among people with HIV

AU - Drumright, Lydia N.

AU - Nance, Robin M.

AU - Ruderman, Stephanie A.

AU - Ma, Jimmy

AU - Whitney, Bridget M.

AU - Hahn, Andrew

AU - Fredericksen, Rob J.

AU - Luu, Brandon

AU - Lober, William B.

AU - Moore, Richard D.

AU - Budoff, Matthew J.

AU - Keruly, Jeanne C.

AU - Christopoulos, Katerina

AU - Puryear, Sarah

AU - Willig, Amanda

AU - Cropsey, Karen

AU - Mathews, William C.

AU - Cachay, Edward

AU - Bamford, Laura

AU - Eron, Joseph J.

AU - Napravnik, Sonia

AU - Mayer, Kenneth H.

AU - O'Cleirigh, Conall

AU - Mccaul, Mary E.

AU - Chander, Geetanjali

AU - Feinstein, Matthew J.

AU - Saag, Michael S.

AU - Kitahata, Mari M.

AU - Heckbert, Susan R.

AU - Crane, Heidi M.

AU - Delaney, Joseph A.C.

PY - 2023/6

Y1 - 2023/6

N2 - Objectives: People with HIV have a higher risk of myocardial infarction (MI) than the general population, with a greater proportion of type 2 MI (T2MI) due to oxygen demand–supply mismatch compared with type 1 (T1MI) resulting from atherothrombotic plaque disruption. People living with HIV report a greater prevalence of cigarette and alcohol use than do the general population. Alcohol use and smoking as risk factors for MI by type are not well studied among people living with HIV. We examined longitudinal associations between smoking and alcohol use patterns and MI by type among people living with HIV. Design and Methods: Using longitudinal data from the Centers for AIDS Research Network of Integrated Clinical Systems cohort, we conducted time-updated Cox proportional hazards models to determine the impact of smoking and alcohol consumption on adjudicated T1MI and T2MI. Results: Among 13 506 people living with HIV, with a median 4 years of follow-up, we observed 177 T1MI and 141 T2MI. Current smoking was associated with a 60% increase in risk of both T1MI and T2MI. In addition, every cigarette smoked per day was associated with a 4% increase in risk of T1MI, with a suggestive, but not significant, 2% increase for T2MI. Cigarette use had a greater impact on T1MI for men than for women and on T2MI for women than for men. Increasing alcohol use was associated with a lower risk of T1MI but not T2MI. Frequency of heavy episodic alcohol use was not associated with MI. Conclusions: Our findings reinforce the prioritization of smoking reduction, even without cessation, and cessation among people living with HIV for MI prevention and highlight the different impacts on MI type by gender.

AB - Objectives: People with HIV have a higher risk of myocardial infarction (MI) than the general population, with a greater proportion of type 2 MI (T2MI) due to oxygen demand–supply mismatch compared with type 1 (T1MI) resulting from atherothrombotic plaque disruption. People living with HIV report a greater prevalence of cigarette and alcohol use than do the general population. Alcohol use and smoking as risk factors for MI by type are not well studied among people living with HIV. We examined longitudinal associations between smoking and alcohol use patterns and MI by type among people living with HIV. Design and Methods: Using longitudinal data from the Centers for AIDS Research Network of Integrated Clinical Systems cohort, we conducted time-updated Cox proportional hazards models to determine the impact of smoking and alcohol consumption on adjudicated T1MI and T2MI. Results: Among 13 506 people living with HIV, with a median 4 years of follow-up, we observed 177 T1MI and 141 T2MI. Current smoking was associated with a 60% increase in risk of both T1MI and T2MI. In addition, every cigarette smoked per day was associated with a 4% increase in risk of T1MI, with a suggestive, but not significant, 2% increase for T2MI. Cigarette use had a greater impact on T1MI for men than for women and on T2MI for women than for men. Increasing alcohol use was associated with a lower risk of T1MI but not T2MI. Frequency of heavy episodic alcohol use was not associated with MI. Conclusions: Our findings reinforce the prioritization of smoking reduction, even without cessation, and cessation among people living with HIV for MI prevention and highlight the different impacts on MI type by gender.

KW - HIV

KW - alcohol use

KW - binge drinking

KW - people with HIV

KW - smoking

KW - type 1 myocardial infarction

KW - type 2 myocardial infarction

UR - http://www.scopus.com/inward/record.url?scp=85149958928&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85149958928&partnerID=8YFLogxK

U2 - 10.1111/hiv.13466

DO - 10.1111/hiv.13466

M3 - Article

C2 - 36855253

AN - SCOPUS:85149958928

SN - 1464-2662

VL - 24

SP - 703

EP - 715

JO - HIV Medicine

JF - HIV Medicine

IS - 6

ER -

Associations between alcohol and cigarette use and type 1 and 2 myocardial infarction among people with HIV

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this